The effect of Zingiber Officinale in the treatment of ulcerative colitis

Authors

DOI:

https://doi.org/10.33448/rsd-v12i10.37795

Keywords:

Ulcerative colitis; Ginger; Zingiber officinale.

Abstract

Ulcerative colitis is an inflammatory bowel disease, which is characterized by rectal bleeding, abdominal pain, fever, weight loss and diarrhea, is a chronic disease and tends to be progressive, drastically affecting the population's quality of life. It’s conventional treatment consists on the administration of oral or topical aminosalicylates and also corticotherapy, where it’s main objective is symptom control, nutritional balance and improvement of the patient's quality of life, and despite being efficient, it is very expensive and also has multiple side effects, that end up decreasing adherence to treatment. From this, the purpose of this narrative review is to evaluate previous studies on the properties of Zingiber officinale, which are widely known for their anti-inflammatory and antioxidant capacity, and also to analyze studies that used ginger for the treatment of ulcerative colitis, it’s epidemiological aspects and it’s conventional treatment. Despite limited but growing literature exploring the use of ginger in the treatment of ulcerative colitis, good results were presented and further research using this plant is necessary.

References

Ahui, M. L., Champy, P., Ramadan, A., Pham Van, L., Araujo, L., Brou André, K., Diem, S., Damotte, D., Kati-Coulibaly, S., Offoumou, M. A., Dy, M., Thieblemont, N., & Herbelin, A. (2008). Ginger prevents Th2-mediated immune responses in a mouse model of airway inflammation. International immunopharmacology, 8(12), 1626–1632. https://doi.org/10.1016/j.intimp.2008.07.009

Ajayi, B. O., Adedara, I. A., & Farombi, E. O. (2018). Protective mechanisms of 6-gingerol in dextran sulfate sodium-induced chronic ulcerative colitis in mice. Human & experimental toxicology, 37(10), 1054–1068. https://doi.org/10.1177/0960327117751235

Asakura, K., Nishiwaki, Y., Inoue, N., Hibi, T., Watanabe, M., & Takebayashi, T. (2009). Prevalence of ulcerative colitis and Crohn's disease in Japan. Journal of gastroenterology, 44(7), 659–665. https://doi.org/10.1007/s00535-009-0057-3

Barbosa, K. B. F., Costa, N. M. B., Alfenas, R. C. G., Paula, S. O., Minim, V. P. R. & Bressan, J. (2010). Estresse oxidativo: conceito, implicações e fatores modulatórios. Revista de Nutrição, 23(4), 629-643. https://doi.org/10.1590/S1415-52732010000400013

Barreto, A. M. C., Toscano, B. A. F. & Fortes, R. C. (2011). Efeitos do gengibre (Zingiber officinale) em pacientes oncológicos tratados com quimioterapia. Com. Ciências Saúde, 22(3), 257-270. https://bvsms.saude.gov.br/bvs/periodicos/revista_ESCS_v22_n3_a08_efeitos_gengibre.pdf

Biondo-Simões, M. L. P., Mandelli, K. K., Pereira, M. A. C. & Faturi, J. L. (2003). Opções terapêuticas para as doenças inflamatórias intestinais: revisão. Rev Bras Coloproct, 23(3), 172-182. https://pesquisa.bvsalud.org/portal/resource/pt/lil-357985

Conceição, K. P. P. (2019). Efeito anti-inflamatório do gengibre. Mestrado Integrado em Ciências Farmacêuticas. Instituto Universitário Egas Moniz, Brasil.

Correa, B. R., Becale, M. S., Ferreira, F. B., Martins, F. Q., Clara, A. P. H. S., Lorentz, F. W. (2020). Reações adversas no tratamento da doença inflamatória intestinal em um Ambulatório de Referência. Arq Med Hosp Fac Cienc Med Santa Casa São Paulo, 65(39). https://doi.org/10.26432/1809-3019.2020.65.039

Cordeiro, A. M., Oliveira, G. M., Rentería, J. M. & Guimarães, C. A. (2007). Revisão sistemática: uma revisão narrativa. Revista do Colégio Brasileiro de Cirurgiões, 34(6), 428-431. doi: 10.1590/S0100-69912007000600012

Correia A. M. R. & Mesquita A (2014). Mestrados e Doutoramentos. Porto: Vida Economica Editorial, (2a ed.) 217-218.

Dileep R., Usharani M., Gopu B., Reddy A.G., Kumar M.V., Kumar C.S. & Madhuri D. (2016). Ameliorative effect of ginger extract in acetic acid induced ulcerative colitis in rats. Asian J Anim Vet Adv., 11, 130–136. 10.3923/ajava.2016.130.136.

El-Abhar, H. S., Hammad, L. N., & Gawad, H. S. (2008). Modulating effect of ginger extract on rats with ulcerative colitis. Journal of ethnopharmacology, 118(3), 367–372. https://doi.org/10.1016/j.jep.2008.04.026

Freitas, T. H. P. & Souza, D. A. F. (2007). Corticosteróides sistêmicos na prática dermatológica. Parte I: Principais efeitos adversos. Anais Brasileiros de Dermatologia, 82(1), 63-70. https://doi.org/10.1590/S0365-05962007000100009

Fróes, R. (2014). Tratamento Convencional na Doença Inflamatória Intestinal. Revista Hospital Universitário Pedro Ernesto, 11(4).

Ghosh, S., Shand, A., & Ferguson, A. (2000). Ulcerative colitis. BMJ (Clinical research ed.), 320(7242), 1119–1123. https://doi.org/10.1136/bmj.320.7242.1119

Hsiang, C. Y., Lo, H. Y., Huang, H. C., Li, C. C., Wu, S. L., & Ho, T. Y. (2013). Ginger extract and zingerone ameliorated trinitrobenzene sulphonic acid-induced colitis in mice via modulation of nuclear factor-κB activity and interleukin-1β signalling pathway. Food chemistry, 136(1), 170–177. https://doi.org/10.1016/j.foodchem.2012.07.124

Lee, H. Y., Park, S. H., Lee, M., Kim, H. J., Ryu, S. Y., Kim, N. D., Hwang, B. Y., Hong, J. T., Han, S. B., & Kim, Y. (2012). 1-Dehydro-[10]-gingerdione from ginger inhibits IKKβ activity for NF-κB activation and suppresses NF-κB-regulated expression of inflammatory genes. British journal of pharmacology, 167(1), 128–140. https://doi.org/10.1111/j.1476-5381.2012.01980.x

Llufrio, P. D. V., Estopiñan, S. C., Fagundo, L. P., Báez, A. G., Fernández, S. P. & Herrera, O. G. (2020). Severe extensive ulcerative colitis. Case presentation. Rev. Med. Electrón, 42(3).

Loftus E. V., Jr (2004). Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology, 126(6), 1504–1517. https://doi.org/10.1053/j.gastro.2004.01.063

Lucio, I. B., Freitas, R. J. S. & Waszczynskyj, N. (2010). Composição físico-química e aceitação sensorial da inflorescência de gengibre orgânico (Zingiber officinale Roscoe). Revista Ciência e Tecnologia de Alimento, 30(3), 652-656. https://doi.org/10.1590/S0101-20612010000300013

Ministério da Saúde. (2016). Política e Programa Nacional de Plantas Medicinais e Fitoterápicos. Organização: Ministério da Saúde, Secretaria de Ciência, Tecnologia e Insumos Estratégicos, Departamento de Assistência Farmacêutica, Brasília, Brasil.

Nikkhah Bodagh, M., Maleki, I., & Hekmatdoost, A. (2018). Ginger in gastrointestinal disorders: A systematic review of clinical trials. Food science & nutrition, 7(1), 96–108. https://doi.org/10.1002/fsn3.807

Nikkhah-Bodaghi, M., Maleki, I., Agah, S., & Hekmatdoost, A. (2019). Zingiber officinale and oxidative stress in patients with ulcerative colitis: A randomized, placebo-controlled, clinical trial. Complementary therapies in medicine, 43, 1–6. https://doi.org/10.1016/j.ctim.2018.12.021

Ordás, I., Eckmann, L., Talamini, M., Baumgart, D. C., & Sandborn, W. J. (2012). Ulcerative colitis. Lancet (London, England), 380(9853), 1606–1619. https://doi.org/10.1016/S0140-6736(12)60150-0

Papatheodoridis, G. V., Hamilton, M., Mistry, P. K., Davidson, B., Rolles, K., & Burroughs, A. K. (1998). Ulcerative colitis has an aggressive course after orthotopic liver transplantation for primary sclerosing cholangitis. Gut, 43(5), 639–644. https://doi.org/10.1136/gut.43.5.639

Papatheodoridis, G. V., Hamilton, M., Rolles, K., & Burroughs, A. K. (1998). Liver transplantation and inflammatory bowel disease. Journal of hepatology, 28(6), 1070–1076. https://doi.org/10.1016/s0168-8278(98)80359-0

Pithawa, A. K. (2007). Sleisenger and Fordtran's Gastrointestinal and Liver Disease: pathophysiology, diagnosis, management. Medical Journal, Armed Forces India, 63(2), 205. https://doi.org/10.1016/S0377-1237(07)80085-2

Shayesteh, F., Haidari, F., Shayesteh, A. A., Mohammadi-Asl, J., & Ahmadi-Angali, K. (2020). Ginger in patients with active ulcerative colitis: a study protocol for a randomized controlled trial. Trials, 21(1), 278. https://doi.org/10.1186/s13063-020-4193-7

Souza, M. M., Barbosa, D. A., Espinosa, M. M. & Belasco, A. G. S. (2011). Qualidade de vida de pacientes portadores de doença inflamatória intestinal. Acta paulista de enfermagem, 24(4), 479-484. https://doi.org/10.1590/S0103-21002011000400006

Vieira, N. A., Tomiotto-Pellissier, F., Melo, G. P., Manchope, M., Lima, N., Oliveira, G. & Watanabe, M. (2014). Efeito anti-inflamatório do gengibre e possível via de sinalização. Semina: Ciências Biológicas e da Saúde, 35(1), 149. 10.5433/1679-0367.2014v35n1p149

Zhang, F., Ma, N., Gao, Y. F., Sun, L. L., & Zhang, J. G. (2017). Therapeutic Effects of 6-Gingerol, 8-Gingerol, and 10-Gingerol on Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis in Rats. Phytotherapy research : PTR, 31(9), 1427–1432. https://doi.org/10.1002/ptr.5871

Zhang, M., Wang, X., Han, M. K., Collins, J. F., & Merlin, D. (2017). Oral administration of ginger-derived nanolipids loaded with siRNA as a novel approach for efficient siRNA drug delivery to treat ulcerative colitis. Nanomedicine (London, England), 12(16), 1927–1943. https://doi.org/10.2217/nnm-2017-0196

Zhang, M., Xu, C., Liu, D., Han, M. K., Wang, L., & Merlin, D. (2018). Oral Delivery of Nanoparticles Loaded With Ginger Active Compound, 6-Shogaol, Attenuates Ulcerative Colitis and Promotes Wound Healing in a Murine Model of Ulcerative Colitis. Journal of Crohn's & colitis, 12(2), 217–229. https://doi.org/10.1093/ecco-jcc/jjx115

Zuluaga-Arbeláez, N., Sierra-Vargas, E. C., Díaz-Coronado, J. C. & Guevara-Casallas, L. G. (2020). Colitis ulcerativa para no gastroenterólogos. CES Medicina, 34(3), 188-197. https://doi.org/10.21615/cesmedicina.34.3.2

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Published

02/10/2023

How to Cite

MOMM, A. B. G. .; SANTOS, C. H. M. dos .; IUNES, G. M. .; KHODR, J. M. .; JERONYMO, L. F. .; BRÜNE, M. E. S. . The effect of Zingiber Officinale in the treatment of ulcerative colitis. Research, Society and Development, [S. l.], v. 12, n. 10, p. e16121037795, 2023. DOI: 10.33448/rsd-v12i10.37795. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/37795. Acesso em: 14 may. 2024.

Issue

Vol. 12 No. 10

Section

Health Sciences

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Copyright (c) 2023 Ana Bárbara Gonçalves Momm; Carlos Henrique Marques dos Santos; Gustavo Mazzafera Iunes; Juliana Machado Khodr; Lucas Ferreira Jeronymo; Maria Eduarda Soares Brüne

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