Tratamentos cirúrgicos da osteonecrose dos maxilares relacionada a medicamentos: vantagens e limitações

Autores

DOI:

https://doi.org/10.33448/rsd-v12i4.41161

Palavras-chave:

Osteonecrose; Osteonecrose da arcada osseodentária associada a difosfonatos; Procedimentos cirúrgicos bucais; Doenças maxilomandibulares.

Resumo

Objetivo: O objetivo deste trabalho é discutir os métodos cirúrgicos disponíveis para o tratamento da OMRM, apontando suas vantagens e limitações. Metodologia: Foi realizada uma revisão integrativa da literatura, através de busca conduzida na base de dados virtuais PubMed, a partir do termo MeSH em inglês “bisphosphonate associated osteonecrosis of the jaw/surgery” e inclusão de 26 publicações. Resultados: A intervenção cirúrgica é uma opção de tratamento que busca reduzir a progressão da doença, na qual, a intervenção precoce pode predizer resultados benéficos para o paciente. As abordagens cirúrgicas conferem resultados superiores aos regimes terapêuticos conservadores, com taxas de sucesso de 80-90% e 10-62%, respectivamente. Para estabelecer o tratamento, deve-se levar em consideração a remoção do osso necrótico que pode ser realizada através de curetagem, sequestrectomia e ressecção cirúrgica. Já para abordagem dos tecidos moles, podem ser realizados diferentes retalhos de acordo com as indicações. Conclusão: O tratamento cirúrgico demonstrou manutenção da cobertura da mucosa, melhora da qualidade de vida e retomada rápida da terapia antirreabsortiva para todos os estágios da doença, apresentando elevadas taxas de sucesso terapêutico. Entretanto, devem ser estimulados esforços contínuos de investigação do melhor tratamento para esta patologia.

Referências

Aljohani, S., Troeltzsch, M., Hafner, S., Kaeppler, G., Mast, G., & Otto, S. (2019). Surgical treatment of medication-related osteonecrosis of the upper jaw: Case series. Oral diseases, 25(2), 497–507. https://doi.org/10.1111/odi.12992

Caldroney, S., Ghazali, N., Dyalram, D., & Lubek, J. E. (2017). Surgical resection and vascularized bone reconstruction in advanced stage medication-related osteonecrosis of the jaw. International journal of oral and maxillofacial surgery, 46(7), 871–876. https://doi.org/10.1016/j.ijom.2017.01.023

Choi, N. R., Lee, J. H., Park, J. Y., & Hwang, D. S. (2020). Surgical Treatment of Medication-Related Osteonecrosis of the Jaw: A Retrospective Study. International journal of environmental research and public health, 17(23), 8801. https://doi.org/10.3390/ijerph17238801

El-Rabbany, M., Blanas, N., Sutherland, S., Lam, D. K., Shah, P. S., & Azarpazhooh, A. (2022). Surgical Therapy in Patients With Medication-Related Osteonecrosis of the Jaw Is Associated With Disease Resolution and Improved Quality of Life: A Prospective Cohort Study. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 80(6), 1084–1093. https://doi.org/10.1016/j.joms.2022.01.012

El-Rabbany, M., Lam, D. K., Shah, P. S., & Azarpazhooh, A. (2019). Surgical Management of Medication-Related Osteonecrosis of the Jaw Is Associated With Improved Disease Resolution: A Retrospective Cohort Study. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 77(9), 1816–1822. https://doi.org/10.1016/j.joms.2019.03.040

Favia, G., Tempesta, A., Limongelli, L., Crincoli, V., & Maiorano, E. (2018). Medication-related osteonecrosis of the jaw: Surgical or non-surgical treatment? Oral diseases, 24(1-2), 238–242. https://doi.org/10.1111/odi.12764

Giudice, A., Barone, S., Diodati, F., Antonelli, A., Nocini, R., & Cristofaro, M. G. (2020). Can Surgical Management Improve Resolution of Medication-Related Osteonecrosis of the Jaw at Early Stages? A Prospective Cohort Study. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 78(11), 1986–1999. https://doi.org/10.1016/j.joms.2020.05.037

Guo, Y., & Guo, C. (2021). Enhancement of bone perfusion through cortical perforations to improve healing of medication-related osteonecrosis of the jaw: a retrospective study. International journal of oral and maxillofacial surgery, 50(6), 740–745. https://doi.org/10.1016/j.ijom.2020.07.036

Hallmer, F., Andersson, G., Götrick, B., Warfvinge, G., Anderud, J., & Bjørnland, T. (2018). Prevalence, initiating factor, and treatment outcome of medication-related osteonecrosis of the jaw-a 4-year prospective study. Oral surgery, oral medicine, oral pathology and oral radiology, 126(6), 477–485. https://doi.org/10.1016/j.oooo.2018.08.015

Hauer, L., Jambura, J., Hrusak, D., Chalupova, M., Posta, P., Rusnak, S., & Vyskocil, V. (2020). Surgical therapy for medication-related osteonecrosis of the jaw in osteoporotic patients treated with antiresorptive agents. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 164(1), 100–107. https://doi.org/10.5507/bp.2018.081

Hayashida, S., Soutome, S., Yanamoto, S., Fujita, S., Hasegawa, T., Komori, T., Kojima, Y., Miyamoto, H., Shibuya, Y., Ueda, N., Kirita, T., Nakahara, H., Shinohara, M., & Umeda, M. (2017). Evaluation of the Treatment Strategies for Medication-Related Osteonecrosis of the Jaws (MRONJ) and the Factors Affecting Treatment Outcome: A Multicenter Retrospective Study with Propensity Score Matching Analysis. Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research, 32(10), 2022–2029. https://doi.org/10.1002/jbmr.3191

Jose, A., Rawat, A., Nagori, S. A., Arya, S., & Shukla, D. (2022). Outcomes of sequestrectomy and buccal fat pad reconstruction in the management of medication-related osteonecrosis of the jaws. Oral and maxillofacial surgery, 26(1), 147–153. https://doi.org/10.1007/s10006-021-00973-9

Kagami, H., Inoue, M., Kobayashi, A., Taguchi, A., Li, X., & Yoshizawa, M. (2018). Issues with the surgical treatment of antiresorptive agent-related osteonecrosis of the jaws. Oral diseases, 24(1-2), 52–56. https://doi.org/10.1111/odi.12783

Kim, H. Y., Lee, S. J., Kim, S. M., Myoung, H., Hwang, S. J., Choi, J. Y., Lee, J. H., Choung, P. H., Kim, M. J., & Seo, B. M. (2017). Extensive Surgical Procedures Result in Better Treatment Outcomes for Bisphosphonate-Related Osteonecrosis of the Jaw in Patients With Osteoporosis. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 75(7), 1404–1413. https://doi.org/10.1016/j.joms.2016.12.014

Lemound, J., Muecke, T., Zeller, A. N., Lichtenstein, J., Eckardt, A., & Gellrich, N. C. (2018). Nasolabial Flap Improves Healing in Medication-Related Osteonecrosis of the Jaw. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 76(4), 877–885. https://doi.org/10.1016/j.joms.2017.09.021

Moll, S., Mueller, S., Meier, J. K., Reichert, T. E., Ettl, T., & Klingelhöffer, C. (2021). Patients' quality of life improves after surgical intervention of stage III medication-related osteonecrosis of the jaw. Oral and maxillofacial surgery, 25(3), 359–366. https://doi.org/10.1007/s10006-020-00927-7

Nisi, M., Izzetti, R., Gennai, S., Bellini, P., Graziani, F., & Gabriele, M. (2020). Surgical Management of Medication-Related Osteonecrosis of the Jaw Patients Related to Dental Implants. The Journal of craniofacial surgery, 31(4), 1037–1041. https://doi.org/10.1097/SCS.0000000000006283

Nisi, M., Karapetsa, D., Gennai, S., Ramaglia, L., Graziani, F., & Gabriele, M. (2018). Conservative surgical treatment of medication related osteonecrosis of the jaw (MRONJ) lesions in patients affected by osteoporosis exposed to oral bisphosphonates: 24 months follow-up. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 46(7), 1153–1158. https://doi.org/10.1016/j.jcms.2018.05.003

Nonnenmühlen, N., Burnic, A., Bartella, A., Lethaus, B., Gerhards, F., Ristow, O., Pautke, C., Hölzle, F., & Steiner, T. (2019). Comparison of mucosal and mucoperiosteal wound cover for the treatment of medication-related osteonecrosis of the jaw lesions: a retrospective cohort study. Clinical oral investigations, 23(1), 351–359. https://doi.org/10.1007/s00784-018-2443-9

Oteri, G., De Ponte, F. S., Runci, M., Peditto, M., Marcianò, A., & Cicciù, M. (2018). Oral-Health-Related Quality of Life After Surgical Treatment of Osteonecrosis of the Jaws. The Journal of craniofacial surgery, 29(2), 403–408. https://doi.org/10.1097/SCS.0000000000004087

Palla, B., Burian, E., Deek, A., Scott, C., Anderson, J., Callahan, N., & Carlson, E. R. (2021). Comparing the Surgical Response of Bisphosphonate-Related Versus Denosumab-Related Osteonecrosis of the Jaws. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 79(5), 1045–1052. https://doi.org/10.1016/j.joms.2020.11.017

Ristow, O., Rückschloß, T., Bodem, J., Berger, M., Bodem, E., Kargus, S., Engel, M., Hoffmann, J., & Freudlsperger, C. (2018). Double-layer closure techniques after bone surgery of medication-related osteonecrosis of the jaw - A single center cohort study. Journal of cranio-maxillo-facial surgery: official publication of the European Association for Cranio-Maxillo-Facial Surgery, 46(5), 815–824. https://doi.org/10.1016/j.jcms.2018.03.005

Rothweiler, R., Voss, P. J., Schmelzeisen, R., & Metzger, M. C. (2021). Medication-related osteonecrosis of the mandible: an unusual presentation and treatment. International journal of oral and maxillofacial surgery, 50(4), 511–515. https://doi.org/10.1016/j.ijom.2020.07.033

Ruggiero, S. L., Dodson, T. B., Aghaloo, T., Carlson, E. R., Ward, B. B., & Kademani, D. (2022). American Association of Oral and Maxillofacial Surgeons' Position Paper on Medication-Related Osteonecrosis of the Jaws-2022 Update. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 80(5), 920–943. https://doi.org/10.1016/j.joms.2022.02.008

Sacco, R., Sacco, N., Hamid, U., Ali, S. H., Singh, M., & Blythe, J. S. J. (2018). Microsurgical Reconstruction of the Jaws Using Vascularised Free Flap Technique in Patients with Medication-Related Osteonecrosis: A Systematic Review. BioMed research international, 2018, 9858921. https://doi.org/10.1155/2018/9858921

Sacco, R., Umar, G., Guerra, R. C., & Akintola, O. (2021). Evaluation of segmental mandibular resection without microvascular reconstruction in patients affected by medication-related osteonecrosis of the jaw: a systematic review. The British journal of oral & maxillofacial surgery, 59(6), 648–660. https://doi.org/10.1016/j.bjoms.2020.12.014

Souza, M. T. de., Silva, M. D. da, & Carvalho, R. de.. (2010). Integrative review: what is it? How to do it?. Einstein (são Paulo), 8(einstein (São Paulo), 2010 8(1)), 102–106. https://doi.org/10.1590/S1679-45082010RW1134

Whittemore, R., & Knafl, K. (2005). The integrative review: updated methodology. Journal of advanced nursing, 52(5), 546–553. https://doi.org/10.1111/j.1365-2648.2005.03621.x

Downloads

Publicado

17/04/2023

Como Citar

SILVA , N. S. da .; SANTIAGO, S. B. S. .; CAMPOS, D. N. .; SILVA, L. C. B. F. da .; CABRAL , J. L. de O. A. .; SOUSA , E. M. .; TUÑAS, I. T. de C. . Tratamentos cirúrgicos da osteonecrose dos maxilares relacionada a medicamentos: vantagens e limitações. Research, Society and Development, [S. l.], v. 12, n. 4, p. e24412441161, 2023. DOI: 10.33448/rsd-v12i4.41161. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/41161. Acesso em: 19 maio. 2024.

Edição

Seção

Ciências da Saúde