Osteonecrosis as a post-surgical complication in oral surgery in patients undergoing antiresorptive treatment. Integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v12i7.42489

Keywords:

Osteonecrosis; Bisphosphonates; Complications; Oral surgery; Antiresorptives.

Abstract

Currently, the administration of antiresorptive drugs for the treatment of different diseases related to bone tissue has been increasing. However, they can also trigger complications that we as health professionals should be aware of. Today there is a lot of information about the subject, for this reason, it is important that we have more relevant and concrete information that is easy to understand for a general practice dentist to detect this affectation early, assessing the risks and benefits that such treatments entail, the objective of the This review is to make a comprehensible synthesis of the most important aspects of osteonecrosis of the jaw related to antiresorptive drugs and the care to be taken into account. A thorough search was carried out in different databases: Pubmed, EBSCO, Science Direct, Scopus, Scielo. Being included 27 articles from 2019, 1 base article, 1 clinical guide and 1 book for the present review. Osteonecrosis is a complication that can appear after the administration of antiresorptive drugs such as bisphosnates and denosumad used in the treatment of bone diseases. Those administered intravenously have been reported mostly with the development of this complication, among the triggering local risk factors. extractions predominate. The multidisciplinary approach is essential for early recognition of predisposing patients, providing timely and preventive care to reduce the severity of this complication.

References

Al-Maawi, S., Becker, K., Schwarz, F., Sader, R., & Ghanaati, S. (2021). Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review. International Journal of Implant Dentistry, 7(1). https://doi.org/10.1186/s40729-021-00393-0

Altay M, Radu, A., Pack, S. E., Yıldırımyan, N., Flores-Hidalgo, A., Baur, D. A., & Quereshy, F. A. (2020). Medication-related osteonecrosis of the jaw: An institution’s experience. Cranio - Journal of Craniomandibular and Sleep Practice, 38(5), 333–341. https://doi.org/10.1080/08869634.2018.1528711

Bacci, C., Cerrato, A., Dotto, V., Zambello, R., Barilà, G., Liço, A., Semenzato, G., Stellini, E., & Zanette, G. (2021). The importance of alliance between hematologists and dentists: A retrospective study on the development of bisphosphonates osteonecrosis of the jaws (bronj) in multiple myeloma patients. Dentistry Journal, 9(2). https://doi.org/10.3390/dj9020011

Bansal, H. (2022). Medication-related osteonecrosis of the jaw: An update. In National Journal of Maxillofacial Surgery (Vol. 13, Issue 1, pp. 5–10). Wolters Kluwer Medknow Publications. https://doi.org/10.4103/njms.NJMS_236_20

Burns, M., & Patel, V. (2022). Osteonecrosis of the jaw in primary dental care: Recognition and referral. Primary Dental Journal, 11(3), 108–116. https://doi.org/10.1177/20501684221112512

Cabras, M., Gambino, A., Broccoletti, R., Sciascia, S., & Arduino, P. G. (2021). Lack of evidence in reducing risk of mronj after teeth extractions with systemic antibiotics. In Journal of Oral Science (Vol. 63, Issue 3, pp. 217–226). Nihon University, School of Dentistry. https://doi.org/10.2334/josnusd.21-0016

Contaldo, M., Luzzi, V., Ierardo, G., Raimondo, E., Boccellino, M., Ferati, K., Bexheti-Ferati, A., Inchingolo, F., Di Domenico, M., Serpico, R., Polimeni, A., & Bossù, M. (2020). Bisphosphonate-related osteonecrosis of the jaws and dental surgery procedures in children and young people with osteogenesis imperfecta: A systematic review. In Journal of Stomatology, Oral and Maxillofacial Surgery (Vol. 121, Issue 5, pp. 556–562). Elsevier Masson s.r.l. https://doi.org/10.1016/j.jormas.2020.03.003

Coropciuc, R., Coopman, R., Garip, M., Gielen, E., Politis, C., Van den Wyngaert, T., & Beuselinck, B. (2023). Risk of medication-related osteonecrosis of the jaw after dental extractions in patients receiving antiresorptive agents — A retrospective study of 240 patients. Bone, 170. https://doi.org/10.1016/j.bone.2023.116722

Crossetti, M. (2012). Revisión integrativa de la investigación en enfermería, el rigor científico que se le exige. 33(2), 10–11.

Fusco, V., Campisi, G., Carcieri, P., Fagioli, F., Bertetto, O., Mignogna, M. D., & Bedogni, A. (2022). ONJ (MRONJ) Update 2021—Osteonecrosis of Jaw Related to Bisphosphonates and Other Drugs—Prevention, Diagnosis, Pharmacovigilance, Treatment: A 2021 Web Event. Oral, 2(2), 137–147. https://doi.org/10.3390/oral2020014

Heim, N., Gotz, W., Kramer, F. J., & Faron, A. (2019). Antiresorptive drug-related changes of the mandibular bone densitiy in medication-related osteonecrosis of the jaw patients. Dentomaxillofacial Radiology, 48(8). https://doi.org/10.1259/dmfr.20190132

Heimes, D., Mark, N. A., Kuchen, R., Pabst, A., Becker, P., Kyyak, S., Thiem, D. G. E., Schulze, R., & Kämmerer, P. W. (2023). Evaluation of Medication-Related Osteonecrosis of the Jaw (MRONJ) in Terms of Staging and Treatment Strategies by Dental Students at Different Educational Levels. Medicina (Lithuania), 59(2). https://doi.org/10.3390/medicina59020252

Lončar Brzak, B., Horvat Aleksijević, L., Vindiš, E., Kordić, I., Granić, M., Vidović Juras, D., & Andabak Rogulj, A. (2023). Osteonecrosis of the Jaw. In Dentistry Journal (Vol. 11, Issue 1). MDPI. https://doi.org/10.3390/dj11010023

Misch Carl E. (2009). Implantología Contemporánea (Tercera edición). 2009.

Mu, H., Pang, Y., Liu, L., Liu, J., & Liu, C. (2023). Clinical values of serum Semaphorin 4D (Sema4D) in medication‑related osteonecrosis of the jaw. European Journal of Medical Research, 28(1), 140. https://doi.org/10.1186/s40001-023-01095-6

Otsuru, M., Soutome, S., Hayashida, S., Rokutanda, S., Yanamoto, S., & Umeda, M. (2022). A preliminary clinical study of segmental mandibulectomy on medication-related osteonecrosis of the jaw. Journal of Dental Sciences, 17(1), 444–450. https://doi.org/10.1016/j.jds.2021.07.029

Ottesen, C., Schiodt, M., & Gotfredsen, K. (2020). Efficacy of a high-dose antiresorptive drug holiday to reduce the risk of medication-related osteonecrosis of the jaw (MRONJ): A systematic review. In Heliyon (Vol. 6, Issue 4). Elsevier Ltd. https://doi.org/10.1016/j.heliyon.2020.e03795

Ottesen, C., Schiodt, M., Jensen, S. S., Kofod, T., & Gotfredsen, K. (2022). Tooth extractions in patients with cancer receiving high-dose antiresorptive medication: a randomized clinical feasibility trial of drug holiday versus drug continuation. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 133(2), 165–173. https://doi.org/10.1016/j.oooo.2021.06.003

Patricia, L.-U., & Rica, C. (2014). Prevención de la osteonecrosis de maxilares inducida por bifosfonatos: guía para el odontólogo general. Revisión Bibliográfica. In Rev. Cient. Odontol (Vol. 10, Issue 1).

Pick, E., Leuenberger, N., Kuster, I., Stutzmann, N. S., Stadlinger, B., & Valdec, S. (2021). Evaluation of preventive treatment protocols for patients under antiresorptive therapy undergoing tooth extraction at a swiss university clinic. International Journal of Environmental Research and Public Health, 18(18). https://doi.org/10.3390/ijerph18189924

Poxleitner, P., Steybe, D., Kroneberg, P., Ermer, M. A., Yalcin-Ülker, G. M., Schmelzeisen, R., & Voss, P. J. (2020). Tooth extractions in patients under antiresorptive therapy for osteoporosis: Primary closure of the extraction socket with a mucoperiosteal flap versus application of platelet-rich fibrin for the prevention of antiresorptive agent-related osteonecrosis of the jaw. Journal of Cranio-Maxillofacial Surgery, 48(4), 444–451. https://doi.org/10.1016/j.jcms.2020.02.006

Ruggiero, S. L., Dodson, T. B., Aghaloo, T., Carlson, E. R., Ward, B. B., & Kademani, D. (2022). American Association of Oral and Maxillofacial Surgeons’ Position Paper on Medication-Related Osteonecrosis of the Jaws—2022 Update. In Journal of Oral and Maxillofacial Surgery (Vol. 80, Issue 5, pp. 920–943). W.B. Saunders. https://doi.org/10.1016/j.joms.2022.02.008

Ruggiero, S. L., Dodson, T. B., Fantasia, J., Goodday, R., Aghaloo, T., Mehrotra, B., & O’Ryan, F. (2014). American association of oral and maxillofacial surgeons position paper on medication-related osteonecrosis of the jaw - 2014 update. In Journal of Oral and Maxillofacial Surgery (Vol. 72, Issue 10, pp. 1938–1956). W.B. Saunders. https://doi.org/10.1016/j.joms.2014.04.031

Sacco, R., Sartoretto, S. C., de Brito Resende, R. F., de Albuquerque Calasans-Maia, J., Rossi, A. M., de Souza Lima, V. H., de Almeida Barros Mourão, C. F., Granjeiro, J. M., Yates, J., & Calasans-Maia, M. D. (2023). The Use of Hydroxyapatite Loaded with Doxycycline (HADOX) in Dentoalveolar Surgery as a Risk-Reduction Therapeutic Protocol in Subjects Treated with Different Bisphosphonate Dosages. Medicina (Lithuania), 59(1). https://doi.org/10.3390/medicina59010046

Sacco, R., Woolley, J., Yates, J., Calasans-Maia, M., Akintola, O., & Patel, V. (2021). The role of antiresorptive drugs and medication-related osteonecrosis of the jaw in nononcologic immunosuppressed patients: A systematic review. Journal of Research in Medical Sciences, 26(1). https://doi.org/10.4103/jrms.JRMS_794_20

Sandhu, S., Salous, M. H., Sankar, V., Margalit, D. N., & Villa, A. (2020). Osteonecrosis of the jaw and dental extractions: A single-center experience. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 130(5), 515–521. https://doi.org/10.1016/j.oooo.2020.07.001

Schwech, N., Nilsson, J., & Gabre, P. (2023). Incidence and risk factors for medication-related osteonecrosis after tooth extraction in cancer patients—A systematic review. In Clinical and Experimental Dental Research (Vol. 9, Issue 1, pp. 55–65). John Wiley and Sons Inc. https://doi.org/10.1002/cre2.698

Seki, K., Kaneko, T., Kamimoto, A., Wada, M., Takeuchi, Y., Furuchi, M., & Iinuma, T. (2022). Medication-related osteonecrosis of the jaw after tooth extraction in patients receiving pharmaceutical treatment for osteoporosis: A retrospective cohort study. Journal of Dental Sciences, 17(4), 1619–1625. https://doi.org/10.1016/j.jds.2022.03.014

Shibahara, T. (2019). Antiresorptive agent-related osteonecrosis of the jaw (ARONJ): A twist of fate in the bone. Tohoku Journal of Experimental Medicine, 247(2), 75–86. https://doi.org/10.1620/tjem.247.75

Spanou, A., Nelson, K., Ermer, M. A., Steybe, D., Poxleitner, P., & Voss, P. J. (2020). Primary wound closure and perioperative antibiotic therapy for prevention of bisphosphonate-related osteonecrosis of the jaw after tooth extraction. Quintessence International (Berlin, Germany: 1985), 51(3), 220–228. https://doi.org/10.3290/j.qi.a43949

Taniguchi, N., Osaki, M., Onuma, K., Ishikawa, M., Ryoke, K., Kodani, I., & Okada, F. (2020). Bisphosphonate-induced reactive oxygen species inhibit proliferation and migration of oral fibroblasts: A pathogenesis of bisphosphonate-related osteonecrosis of the jaw. Journal of Periodontology, 91(7), 947–955. https://doi.org/10.1002/JPER.19-0385

Wick, A., Bankosegger, P., Otto, S., Hohlweg-Majert, B., Steiner, T., Probst, F., Ristow, O., & Pautke, C. (2022). Risk factors associated with onset of medication-related osteonecrosis of the jaw in patients treated with denosumab. Clinical Oral Investigations, 26(3), 2839–2852. https://doi.org/10.1007/s00784-021-04261-4

Published

09/07/2023

How to Cite

PINTADO CORREA, S. E. .; PICHISACA ALVAREZ, M. C. .; CALDERÓN CALLE, M. E. . Osteonecrosis as a post-surgical complication in oral surgery in patients undergoing antiresorptive treatment. Integrative review. Research, Society and Development, [S. l.], v. 12, n. 7, p. e2612742489, 2023. DOI: 10.33448/rsd-v12i7.42489. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/42489. Acesso em: 15 may. 2024.

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Section

Health Sciences