Evaluation of the role of vitamin D in patients with psoriasis

Authors

DOI:

https://doi.org/10.33448/rsd-v12i12.43929

Keywords:

Psoriasis; Vitamin D; Immune system.

Abstract

Objectives: Investigate whether there is any association between the levels of vitamin D in the blood and the seriousness of psoriasis or its development. Methods: The study is characterized as observational, retrospective, composed of 40 patients with psoriasis who had serum vitamin D levels, who underwent clinical care at a dermatology outpatient clinic in Passo Fundo/RS, from August 2019 to June 2021.  Results: Of the 40 interviewees, 60% were female and 40% male. Phototypes II and III prevailed. Regarding family health history, 50% had a history of the disease. Regarding the duration of psoriasis, the predominant group was between 1-10 years (57.5%). The most prevalent psoriasis subtype was vulgaris (62.5%). Regarding serum vitamin D results, the lowest index was 15.2 ng ̸ mL, the highest was 42.3 ng ̸ mL and the average was 25.99 ng ̸mL. In the predominant age group, between 20-40 years, the proportion of patients with vitamin D was less than 30 ng ̸mL is 83.33%. The lower the phototype, the greater the proportion of patients with suboptimal serum vitamin D. In the group of patients with disease duration > 10 years, vitamin D levels were lower. There is no extreme difference in the effectiveness of treatments when analyzing the average, minimum and maximum serum levels of vitamin D. Conclusion: There was no relationship between serum levels of 25-hydroxyvitamin D (25OHD) and the development of psoriasis or even control – worsening of the clinical picture of disease.

References

Alzaman, N. S., Dawson-Hughes, B., Nelson, J., D’Alessio, D., & Pittas, A. G. (2016). Vitamin D status of black and white Americans and changes in vitamin D metabolites after varied doses of vitamin D supplementation. The American Journal of Clinical Nutrition, 104(1), 205–214. https://doi.org/10.3945/ajcn.115.129478

Atwa, M. A., Balata, M. G., Hussein, A. M., Abdelrahman, N. I., & Elminshawy, H. H. (2013). Serum 25-hydroxyvitamin D concentration in patients with psoriasis and rheumatoid arthritis and its association with disease activity and serum tumor necrosis factor-alpha. Saudi Medical Journal, 34(8), 806–813. https://pubmed.ncbi.nlm.nih.gov/23974451/

Chandrashekar, L., Gr, K., Medha Rajappa, G. Revathy, M. M., & Devinder M. T. (2015). 25-hydroxy vitamin D and ischaemia-modified albumin levels in psoriasis and their association with disease severity. British Journal of Biomedical Science, 72(2), 56–60. https://doi.org/10.1080/09674845.2015.11666797

da Silva, B. M. B., Teixeira, M., Cardoso, M., Nascimento, P. M. M., & Gonçalves, B. C. M. (2016). Psoríase: Classificação Clínica e Tratamento Tópico. Janus, 13(24).

Dawson-Hughes, B. (2004). Racial/ethnic considerations in making recommendations for vitamin D for adult and elderly men and women. The American Journal of Clinical Nutrition, 80(6), 1763S1766S. https://doi.org/10.1093/ajcn/80.6.1763s

Delvin, E., Souberbielle, J.-C., Viard, J.-P., & Salle, B. (2014). Role of vitamin D in acquired immune and autoimmune diseases. Critical Reviews in Clinical Laboratory Sciences, 51(4), 232–247. https://doi.org/10.3109/10408363.2014.901291

Estrela, C. (2018). Metodologia Científica: Ciência, Ensino, Pesquisa. Editora Artes Médicas

Gisondi, P., Rossini, M., Di Cesare, A., Idolazzi, L., Farina, S., Beltrami, G., Peris, K., & Girolomoni, G. (2012). Vitamin D status in patients with chronic plaque psoriasis. British Journal of Dermatology, 166(3), 505–510. https://doi.org/10.1111/j.1365-2133.2011.10699.x

Gupta, A., Arora, T., Jindal, A., & Bhadoria, A. (2016). Efficacy of narrowband ultraviolet B phototherapy and levels of serum vitamin D3 in psoriasis: A prospective study. Indian Dermatology Online Journal, 7(2), 87. https://doi.org/10.4103/2229-5178.17808

Hagenau, T., Vest, R., Gissel, T. N., Poulsen, C. S., Erlandsen, M., Mosekilde, L., & Vestergaard, P. (2008). Global vitamin D levels in relation to age, gender, skin pigmentation and latitude: an ecologic meta-regression analysis. Osteoporosis International, 20(1), 133–140. https://doi.org/10.1007/s00198-008-0626-y

Hilger, J., Friedel, A., Herr, R., Rausch, T., Roos, F., Wahl, D. A., Pierroz, D. D., Weber, P., & Hoffmann, K. (2013). A systematic review of vitamin D status in populations worldwide. British Journal of Nutrition, 111(1), 23–45. https://doi.org/10.1017/s000711451300184

Machado, E. R., Oliveira, L. B. de, Chaves, P. L. G., Gomes, L. O. R. V., & Lins, J. P. (2019). Psoríase: uma revisão sistemática da literatura. Revista De Iniciação Científica E Extensão, 2(Esp.1), 52. Recuperado de https://revistasfacesa.senaaires.com.br/index.php/iniciacao-cientifica/article/view/22

Zuchi, M. F., Tanaka, A. A., Martins, L. E. A. M., Azevedo, P. O., Schmitt, J. V. (2015). Serum levels of 25-hydroxy vitamin D in psoriatic patients. Anais Brasileiros de Dermatologia, 90(3), 430–432. https://doi.org/10.1590/abd1806-4841.2015352

Morimoto, S., Yoshikawa, K., Keisuke Fukuo, Shiraishi, T., Koh, E., Shunji Imanaka, Kitano, S., & Toshio Ogihara. (1990). Inverse relation between severity of psoriasis and serum 1,25-dihydroxyvitamin D level. Journal of Dermatological Science, 1(4), 277–282. https://doi.org/10.1016/0923-1811(90)90120-

Moscardi, E., Suzana, E., & Ogava. (2017). Psoriasis: etiology, diagnosis and treatment. 29(2), 70–74. https://revista.uninga.br/uningareviews/article/download/1954/1550/564

O que é psoríase e por que ela pode causar problemas no coração? (n.d.). BBC News Brasil. https://www.bbc.com/portuguese/brasil-5021485

Pitukweerakul, S., Thavaraputta, S., Prachuapthunyachart, S., & Karnchanasorn, R. (2019). Hypovitaminosis D is Associated with Psoriasis: A Systematic Review and Meta-Analysis. Kansas Journal of Medicine, 12(4), 103–108. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884011

Soleymani, T., Hung, T., & Soung, J. (2015). The role of vitamin D in psoriasis: a review. International Journal of Dermatology, 54(4), 383–392. https://doi.org/10.1111/ijd.12790

Umar, M., Sastry, K. S., Al Ali, F., Al-Khulaifi, M., Wang, E., & Chouchane, A. I. (2018). Vitamin D and the Pathophysiology of Inflammatory Skin Diseases. Skin Pharmacology and Physiology, 31(2), 74–86. https://doi.org/10.1159/000485132

Vidal, M. de L. (2019). Associação entre os níveis séricos de vitamina D e a gravidade da psoríase. Universidade Federal de Pernambuco. https://repositorio.ufpe.br/handle/123456789/34379

Downloads

Published

18/11/2023

How to Cite

PEDON, I. C. Z. .; FIM , G. M. .; LIBERA, N. K. D. .; MATTOS , A. B. N. de . Evaluation of the role of vitamin D in patients with psoriasis . Research, Society and Development, [S. l.], v. 12, n. 12, p. e100121243929, 2023. DOI: 10.33448/rsd-v12i12.43929. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/43929. Acesso em: 26 feb. 2024.

Issue

Section

Health Sciences