The impact of postmenopause on sleep and sleep disorders: The current state of the art

Authors

DOI:

https://doi.org/10.33448/rsd-v12i13.43961

Keywords:

Sleep wake disorders; Menopause; Hormone replacement therapy.

Abstract

Sleep disorders in postmenopausal women are important symptoms that demonstrate the impact of the hormonal changes that have begun since menopause. Hormonal changes during the transition to postmenopause play a crucial role in sleep disorders, contributing to symptoms such as insomnia, hot flashes, obstructive sleep apnea and restless legs syndrome. Such disorders impact on women's quality of life, increasing the risks of developing chronic and psychological health conditions, including depression, anxiety and cardiovascular disease. In addition, Hormone Replacement Therapy (HRT) in the treatment of menopausal symptoms is the most widely used pharmacological therapy, although its effectiveness in improving sleep quality is still uncertain due to the heterogeneous nature of the results. Sleep hygiene, together with Cognitive-Behavioral Therapy for Insomnia (CBT), has emerged as a promising non-pharmacological approach to the management of sleep disorders in postmenopausal women. The management of sleep disorders in postmenopausal women should be analyzed taking into account the physical, psychological and hormonal aspects of the patients.

References

Atrooz, F., & Salim, S. (2020) Sleep deprivation, oxidative stress and inflammation. Adv Protein Chem Struct Biol. 119:309-336. 10.1016/bs.apcsb.2019.03.001.

Baker, F. C., de Zambotti, M., Colrain, I. M., & Bei, B. (2018) Sleep problems during the menopausal transition: prevalence, impact, and management challenges. Nat Sci Sleep. 10:73-95. 10.2147/NSS.S125807.

Caretto, M., Giannini, A., & Simoncini, T. (2019) An integrated approach to diagnosing and managing sleep disorders in menopausal women. Maturitas. 128:1-3. 10.1016/j.maturitas.2019.06.008.

Castro-Santos, L., de Oliveira Lima, M., Pedrosa, A. K. P., Serenini, R., de Menezes, R. C. E., & Longo-Silva, G. (2023). Sleep and circadian hygiene practices association with sleep quality among Brazilian adults. Sleep Medicine: X, 6, 100088.

Chellappa, S. L., Vujovic, N., Williams, J. S., & Scheer, F. A. J. L. (2019) Impact of Circadian Disruption on Cardiovascular Function and Disease. Trends Endocrinol Metab. 30(10):767-779. 10.1016/j.tem.2019.07.008.

Cintron, D., Lipford, M., Larrea-Mantilla, L., Spencer-Bonilla, G., Lloyd, R., Gionfriddo, M. R., Gunjal, S., Farrell, A. M., Miller, V. M., & Murad, M. H. (2017) Efficacy of menopausal hormone therapy on sleep quality: systematic review and meta-analysis. Endocrine. 55(3):702-711. 10.1007/s12020-016-1072-9.

Galvan, T., Camuso, J., Sullivan, K., Kim, S., White, D., Redline, S., & Joffe, H. (2017) Association of estradiol with sleep apnea in depressed perimenopausal and postmenopausal women: a preliminary study. Menopause. 24(1):112-117. 10.1097/GME.0000000000000737.

Granados, A. (2018). Los 10 mandamientos de la higiene del sueño para adultos (por la World Sleep Society).

Grisotto, G., Farago, J. S., Taneri, P. E., Wehrli, F., Roa-Díaz, Z. M., Minder, B., Glisic, M., Gonzalez-Jaramillo, V., Voortman, T., Marques-Vidal, P., Franco, O. H., & Muka, T. (2022) Dietary factors and onset of natural menopause: A systematic review and meta-analysis. Maturitas. 159:15-32. 10.1016/j.maturitas.2021.12.008.

Guthrie, K. A., Larson, J. C., Ensrud, K. E., Anderson, G. L., Carpenter, J. S., Freeman, E. W., Joffe, H., LaCroix, A. Z., Manson, J. E., Morin, C. M., Newton, K. M., Otte, J., Reed, S. D., & McCurry, S. M. (2018) Effects of Pharmacologic and Nonpharmacologic Interventions on Insomnia Symptoms and Self-reported Sleep Quality in Women With Hot Flashes: A Pooled Analysis of Individual Participant Data From Four MsFLASH Trials. Sleep. 41(1):zsx190. 10.1093/sleep/zsx190.

Haufe, A., Baker, F. C., & Leeners, B. (2022) The role of ovarian hormones in the pathophysiology of perimenopausal sleep disturbances: A systematic review. Sleep Med Rev. 66:101710. 10.1016/j.smrv.2022.101710.

Huang, T., Lin, B. M., Redline, S., Curhan, G. C., Hu, F. B., & Tworoger, S. S. (2018) Type of Menopause, Age at Menopause, and Risk of Developing Obstructive Sleep Apnea in Postmenopausal Women. Am J Epidemiol. 187(7):1370-1379. 10.1093/aje/kwy011.

Kalmbach, D. A., Cheng, P., Arnedt, J. T., Anderson, J. R., Roth, T., Fellman-Couture, C., Williams, R. A., & Drake, C. L. (2019) Treating insomnia improves depression, maladaptive thinking, and hyperarousal in postmenopausal women: comparing cognitive-behavioral therapy for insomnia (CBTI), sleep restriction therapy, and sleep hygiene education. Sleep Med. 55:124-134. 10.1016/j.sleep.2018.11.019.

Kalmbach, D. A., Cheng, P., Arnedt, J. T., Anderson, J. R., Roth, T., Fellman-Couture, C., Williams, R. A., & Drake, C. L. (2019) Treating insomnia improves depression, maladaptive thinking, and hyperarousal in postmenopausal women: comparing cognitive-behavioral therapy for insomnia (CBTI), sleep restriction therapy, and sleep hygiene education. Sleep Med. 55:124-134. 10.1016/j.sleep.2018.11.019.

Khadivzadeh, T., Abdolahian, S., Ghazanfarpour, M., Kargarfard, L., Dizavandi, F. R., & Khorsand, I. (2018) A Systematic Review and Meta-analysis on the Effect of Herbal Medicine to Manage Sleep Dysfunction in Peri- and Postmenopause. J Menopausal Med. 24(2):92-99. 10.6118/jmm.2018.24.2.92.

Klinzing, J. G., Niethard, N., & Born, J. (2019) Mechanisms of systems memory consolidation during sleep. Nat Neurosci. 22(10):1598-1610. 10.1038/s41593-019-0467-3.

Kolesnikova, L. I., Madaeva, I. M., Semenova, N. V., Suturina, L. V., Berdina, O. N., Sholohov, L. F., & Solodova, E. I. (2013) Pathogenic role of melatonin in sleep disorders in menopausal women. Bull Exp Biol Med. 156(1):104-6. 10.1007/s10517-013-2289-8.

Korostovtseva, L., Bochkarev, M., & Sviryaev, Y. (2021) Sleep and Cardiovascular Risk. Sleep Med Clin. 16(3):485-497. 10.1016/j.jsmc.2021.05.001.

Laudisio, D., Barrea, L., Pugliese, G., Aprano, S., Castellucci, B., Savastano, S., Colao, A., & Muscogiuri, G. (2021) A practical nutritional guide for the management of sleep disturbances in menopause. Int J Food Sci Nutr. 72(4):432-446. 10.1080/09637486.2020.1851658.

Lee, J., Han, Y., Cho, H. H., & Kim, M. R. (2019) Sleep disorders and menopause. J Menopausal Med. 25(2):83-87. 10.6118/jmm.19192. Erratum in: J Menopausal Med. 25(3):172.

Lefter, R., Cojocariu, R. O., Ciobica, A., Balmus, I. M., Mavroudis, I., & Kis, A. (2022) Interactions between Sleep and Emotions in Humans and Animal Models. Medicina (Kaunas). 58(2):274. 10.3390/medicina58020274.

Marjoribanks, J., Farquhar, C., Roberts, H., Lethaby, A., & Lee, J. (2017) Long-term hormone therapy for perimenopausal and postmenopausal women. Cochrane Database Syst Rev. 1(1):CD004143. 10.1002/14651858.CD004143.pub5.

Mason, G. M., Lokhandwala, S., Riggins, T., & Spencer, R. M. C. (2021) Sleep and human cognitive development. Sleep Med Rev. 10.1016/j.smrv.2021.101472.

Monteleone, P., Mascagni, G., Giannini, A., Genazzani, A. R., & Simoncini, T. (2018) Symptoms of menopause - global prevalence, physiology and implications. Nat Rev Endocrinol. 14(4):199-215. 10.1038/nrendo.2017.180.

Moreno-Frías, C., Figueroa-Veja, N., & Malacara, J. M. (2014) Relationship of sleep alterations with perimenopausal and postmenopausal symptoms. Menopause. 21(9):1017-22. 10.1097/GME.0000000000000206.

Naufel, M. F., Frange, C., Andersen, M. L., Girão, M. J. B. C., Tufik, S., Beraldi Ribeiro, E., & Hachul, H. (2018) Association between obesity and sleep disorders in postmenopausal women. Menopause. 25(2):139-144. 10.1097/GME.0000000000000962.

Pan, M., Zhou, J., Pan, X., Wang, J., Qi, Q., & Wang, L. (2023) Drugs for the treatment of postmenopausal symptoms: Hormonal and non-hormonal therapy. Life Sci. 312:121255. 10.1016/j.lfs.2022.121255.

Pan, Z., Wen, S., Qiao, X., Yang, M., Shen, X., & Xu, L. (2022) Different regimens of menopausal hormone therapy for improving sleep quality: a systematic review and meta-analysis. Menopause. 29(5):627-635. 10.1097/GME.0000000000001945.

Pop, A. L., Nasui, B. A., Bors, R. G., Penes, O. N., Prada, A. G., Clotea, E., Crisan, S., Cobelschi, C., Mehedintu, C., Carstoiu, M. M., & Varlas, V. N. (2023) The Current Strategy in Hormonal and Non-Hormonal Therapies in Menopause-A Comprehensive Review. Life (Basel). 13(3):649. 10.3390/life13030649.

Stute, P., Marsden, J., Salih, N., & Cagnacci, A. (2023) Reappraising 21 years of the WHI study: Putting the findings in context for clinical practice. Maturitas. 174:8-13. 10.1016/j.maturitas.2023.04.271.

Toffol, E., Kalleinen, N., Haukka, J., Vakkuri, O., Partonen, T., & Polo-Kantola, P. (2014) The effect of hormone therapy on serum melatonin concentrations in premenopausal and postmenopausal women: a randomized, double-blind, placebo-controlled study. Maturitas. 77(4):361-9. 10.1016/j.maturitas.2014.01.015.

Valiensi, S. M., Belardo, M. A., Pilnik, S., Izbizky, G., Starvaggi, A. P., & Castelo Branco, C. (2019) Sleep quality and related factors in postmenopausal women. Maturitas. 123:73-77. 10.1016/j.maturitas.2019.02.008.

Vigeta, S. M. G., Ribeiro, F. M. N., Hachul, H., Tufik, S., & Abi Haidar, M. (2013). O conhecimento da higiene do sono na menopausa. Revista de APS, 16(2).

Xu, Q., & Lang, C. P. (2014) Examining the relationship between subjective sleep disturbance and menopause: a systematic review and meta-analysis. Menopause. 21(12):1301-18. 10.1097/GME.0000000000000240.

Zolfaghari, S., Yao, C., Thompson, C., Gosselin, N., Desautels, A., Dang-Vu, T. T., Postuma, R. B., & Carrier, J. (2020) Effects of menopause on sleep quality and sleep disorders: Canadian Longitudinal Study on Aging. Menopause. 27(3):295-304. 10.1097/GME.0000000000001462.

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Published

01/12/2023

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SILVA, A. A. da .; LIMA, L. de P. P. T. .; MALDONADO, C. F. .; ASSUNÇÃO, I. C. .; AMED, J. P. M. .; KNAIER, S. E. L. .; SANTOS, J. C. C. dos .; STANGHERLIN, L. . The impact of postmenopause on sleep and sleep disorders: The current state of the art. Research, Society and Development, [S. l.], v. 12, n. 13, p. e76121343961, 2023. DOI: 10.33448/rsd-v12i13.43961. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/43961. Acesso em: 14 may. 2024.

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Vol. 12 No. 13

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Review Article

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Copyright (c) 2023 Alexandre Almeida da Silva; Lysandra de Paiva Pinheiro Teixeira Lima; Carolina Franchini Maldonado; Izabella Carvalho Assunção; João Pedro Marçon Amed; Sophia Esmeraldo Leite Knaier; Júlio César Claudino dos Santos; Luana Stangherlin

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