Analysis of unsaturated fatty acids and saturated fatty acids in cardiovascular health and lipid profile

Authors

DOI:

https://doi.org/10.33448/rsd-v12i12.44123

Keywords:

Fatty acids; Treatment; Cardiovascular; Hematologic test; Dyslipidemias.

Abstract

According to the World Health Organization, "cardiovascular disease is the leading cause of death globally, accounting for 30% of global deaths." These deaths are related to atherosclerosis, which is the accumulation of cholesterol in the blood, leading to the buildup of fat in the arteries, ultimately resulting in blockages. Consequently, many individuals seek treatments, including nutritional strategies, to improve, or even prevent, undesirable changes in blood lipid levels and inflammatory markers. Thus, this study aimed to analyze the differences in the impacts that saturated and unsaturated fatty acids can have on cardiovascular health and hematologic test lipid profile. Through the review of scientific articles and guidelines from various countries, it was possible to observe that replacing saturated fats with monounsaturated and polyunsaturated lipids leads to a reduction in inflammatory markers, improves the treatment of dyslipidemias, and, most importantly, decreases cardiovascular risks.

References

Allman-Farinelli, M., Gomes, K., Favaloro, E., & Petocz, P (2005). A Diet Rich in High-Oleic-Acid Sunflower Oil Favorably Alters Low-Density Lipoprotein Cholesterol, Triglycerides, and Factor VII Coagulant Activity. Journal of the Academy of Nutrition and Dietetics, 105(7), 1071-1079.

Ana, S., & Silvia, L. (2004). Mecanismos bioquímicos envolvidos na digestão, absorção e metabolismo dos ácidos graxos ômega. Revista Brasileira em Promoção da Saúde, 17(4), 211-216.

Baer, D., Henderson, T., & Gebauer, S (2021). Consumption of High-Oleic Soybean Oil Improves Lipid and Lipoprotein Profile in Humans Compared to a Palm Oil Blend:A Randomized Controlled Trial. Lipids, 56(3), 313-325.

Belardo, D. Michos, E., Blankstein, R., Blumenthal, R., Ferdinand, K., Hall, K., Klatt, K., Najataran, P., Ostelfd, R., Reddy, K., Rodriguez, R., Sriram, U., Tobias, D., & Gulati, M (2022). Practical, Evidence-Based Approaches to Nutritional Modifications to Reduce Atherosclerotic Cardiovascular Disease: An American Society For Preventive Cardiology Clinical Practice Statement, American Journal of Preventive Cardiology, 2(10), 11.

Binkoski E. A., Etherton-Kris, M. P., Wilson, A. T., Mountain, L. M & Nicolosi, J. R (2005). Balance of Unsaturated Fatty Acids Is Important to a Cholesterol Lowering Diet: Comparison of Mid-Oleic Sunflower Oil and Olive Oil on Cardiovascular Disease Risk Factors; Journal of the Academy of Nutrition and Dietetics, 105(7). 1080-1086

Birthe, R., Bengt, V., Matti, U., Lars, B., Eva, P., Gabrielle, R., Angela, R., Linda, T., Kjeld, H & Study Group, K (2006). Effects of dietary saturated, monounsaturated, and n-3 fatty acids on blood pressure in healthy subjects; The American Journal of Clinical Nutrition, 83(2), 221-226

Botham, K., Mayer, P., Rodwell, V. W., Bender, V., Botham, K., Kenelly, P., & Weil, A (2021). Lipídios de importância fisiológica. Bioquímica Ilustrada de Harper, .1-790.

Brasil. Ministério da Saúde (2022). Gabinete do Ministro. Aterosclerose? https://www.gov.br/saude/pt-br/assuntos/saude-brasil/glossario/aterosclerose.

Domingues, A., Botelho, P., & Bacis, R (2003). A influência da suplementação de triglicerídeos de cadeia média no desempenho em exercícios de ultra-resistência. Scimago Institutions Rankings, 9(6), 6-9.

Elliott, P., Kharath, S & Phillips, C (2022). Plant-Based Diets and Lipid, Lipoprotein, and Inflammatory Biomarkers of Cardiovascular Disease: A Review of Observational and Interventional Studies, Nutrients, 14(24), 14-24.

Han, S., Leka, L., Lichtenstein, A., Ausman, L., Schaefer, E., & Meydani, S (2002). Effect of hydrogenated and saturated, relative to polyunsaturated, fat on immune and inflammatory responses of adults with moderate hypercholesterolemia. Journal of Lipid Research, 43(3), 445-452.

Hooper, L., Martin, N., Jimoh, O., Kirk, C., Foster, E., & Abdelhamid, A (2021). Reduction in saturated fat intake for cardiovascular disease; Cochrane Heart Group, 5(5),1-283

Huan, L., Marsafari, M., Deng, L & Xu, P (2019). Understanding lipogenesis by dynamically profiling transcriptional activity of lipogenic promoters in Yarrowia lipolytica. Appl Microbiol Biotechnol, 103(7), 3167–3179.

IBGE – Instituto Brasileiro de Geografia e Estatística. Pesquisa de orçamentos familiares (2017-2018). Análise do consumo alimentar pessoal no Brasil. https://biblioteca.ibge.gov.br/index.php/biblioteca-catalogo?view=detalhes&id=2101742

Iggman, D., Gustafsson, B., Berglund, L., Marckmann, P & Risérus, U (2011). Replacing dairy fat with rapeseed oil causes rapid improvement of hyperlipidaemia; a randomized controlled study. Journal of Internal Medicine, 270(4), 356-364.

Izar, M., Lottenberg, A., Giraldez, V., Santos Filho, R., Machado, R., Bertolami, A., Assad, M., Saraiva, J., Faludi, A., Moreira, A., Geloneze, B., Magnoni, C., Scherr, C., Amaral, C., Araújo, D., Cintra, D., Nakandakare, E., Fonseca, F., Mota, I., Santos, J., Kato, J., Beda, L., Vieira, L., Bertolami, M., Rogero, M., Lavrador, M., Nakasato, M., Damasceno, N., Alves, R., Soares, L., Costa, R & Machado, V (2021). Posicionamento sobre o Consumo de Gorduras e Saúde Cardiovascular – 2021. Arq Bras Cardiol. SBC, 116(1), 160-212.

Lichtenstein, A., Appel, L., Brands, M., Carnethon, M., Daniels, S., Franch, H., Franklin, B., Kris-Etherton, P., Harris, W., Howards, B., Karanja, N., Lefevre, M., Lawrence, R., Sacks, F., Horn, Linda., Winston, M & Wylie-Rosett, J (2006). Diet and Lifestyle Recommendations Revision 2006, A Scientific Statement From the American Heart Association Nutrition Committee; Aha Journals, 114(1), 82-96.

Lichtenstein, A., Appel, L., Vadiveloo, M., Hu, F., Rebholz, C., Sacks, F., Thorndike, A., Horn & Wylie-Rosset, J. (2021). Dietary Guidance to Improve Cardiovascular Health: A Scientific Statement From the American Heart Association, Aha Journals, 144(23), 472-487.

Li, Y., Hruby, A., Bernstein, A., Ley, S., Wang, D., Chiuve, S., Stephanie, S., Sampson, L., Rexrode, K., Rimm, E., Willet, W & Hu, F(2015). Saturated Fats Compared With Unsaturated Fats and Sources of Carbohydrates in Relation to Risk of Coronary Heart Disease: A Prospective Cohort Study. Journal of the American College of Cardiology, 66(14),1538-1548.

Melo, L., Silva, A., Filho, J., Cozzolino, S. M. F., & Cominetti, C (2013). Bases bioquímicas e fisiológicas da nutrição. Manole, 1-1126.

National Academies of Sciences, Engineering, and Medicine (2023). Dietary reference intakes for energy. The National Academies Press. Washington (DC), 1-528.

Oliveira, S., Nelson, D. L., Cox, M. M. (2014). Lipídios. Lehninger Princípios de Bioquímica. (6a ed.), Sarvier, 1-1259.

Päivärinta, E., Itkonen, S., Pellinen, T., Lehtovirta, M., Erkkola, M & Pajari, A. M. (2020). Replacing Animal-Based Proteins with Plant-Based Proteins Changes the Composition of a Whole Nordic Diet - A Randomised Clinical Trial in Healthy Finnish Adults; Nutrients. Finlândia, 12(4),.4-12.

Reis, A & Spickett, C (2012).Chemistry of phospholipid oxidation. BBA,1818(10),2374-2387.

Rosqvist, F., Iggman, D., Kullberg, J., Cedernaes, J., Johansson, H. E., Larsson, A., Johansson, L., Ahlström, H., Arner, P., Dahlman, I & Risérus, U (2014). Overfeeding Polyunsaturated and Saturated Fat Causes Distinct Effects on Liver and Visceral Fat Accumulation in Humans. Diabetes, 63(7),2356-2368.

Ruuth, M., Lahelma, M., Luukkonen, P., Lorey, M., Qadri, S., Sädervita, S., Hyötyläinen, T., Kovanen, P., Hodson, L., Järvinen, H & Öörni, K (2021). Overfeeding Saturated Fat Increases LDL (Low-Density Lipoprotein) Aggregation Susceptibility While Overfeeding Unsaturated Fat Decreases Proteoglycan-Binding of Lipoproteins; AHA JOURNALS, 41(11), 2823-2836

Santos, R. D., Gagliardi, A. C. M., Xavier, H. T., Magnoni, C. D., Cassani, R., Lottenberg, A. M. P., Casella, F. A., Araújo, D. B., Cesena, F. Y., Alves, R. J., Fenelon, G., Nishioka, S. A. D., Faludi, A. A., Geloneze, B., Scherr, C., Kovacs, C., Tomazzela, C., Carla, C., Barrera-Aleno, D., Cintra, D., Quintão, E., Nakandare, E. R., Fonseca, F. A. H., Pimentel, I., Santos, J. E., Bertolami, M. C., Rogero, M., Izar, M. C., Nakasato M., Damasceno, N. R. T., Maranhão, R., Cassani, R. S. L., Perim, R & Ramos, S (2013). Diretriz sobre o consumo de gorduras e saúde cardiovascular. Arquivo Brasileiro de Cardiologia, Abc Cardiol, 100(1), 49.

Schade, D., Shey, L., & Eaton, P. (2020). Cholesterol Review: A Metabolically Important Molecule; Endocrine Practice, 26(12), 1514-1523.

Souza, M. T. d., Silva, M. D., & Carvalho, R. D. (2010). Integrative review: What is it? How to do it? Einstein, 8(1), 102–106.

Tarino, P., Sun, Q., Hu, F & Krauss, R (2010). Saturated Fatty Acids and Risk of Coronary Heart Disease: Modulation by Replacement Nutrients; Current Atherosclerosis Report, 12(6), 384-390.

Ulven, S., Leder, L., Elind, E., Ottestad, I., Christensen, J., Telle-Hansen, V., Skjetene, A., Raael, E., Sheikh, N., & Holck, M (2016) Exchanging a few commercial, regularly consumed food items with improved fat quality reduces total cholesterol and LDL-cholesterol: a double-blind, randomised controlled trial; Cambridge University Press, 116(8), 1383-1393.

Zhang, K., Li, T., Shan, X., Lu, R., Zhang, S., & Xu, H (2021). Cholesterol: Bioactivities, Structural Modification, Mechanisms of Action, and Structure-Activity Relationships; Mini-Reviews in Medicinal Chemistry, 21(14), 1830-1848

Published

23/11/2023

How to Cite

MARTINOVICH, M. G. .; CRUZ, M. F. de A. . Analysis of unsaturated fatty acids and saturated fatty acids in cardiovascular health and lipid profile. Research, Society and Development, [S. l.], v. 12, n. 12, p. e147121244123, 2023. DOI: 10.33448/rsd-v12i12.44123. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/44123. Acesso em: 14 may. 2024.

Issue

Section

Health Sciences