Casual finding of sickle cell trait S in a middle age adult: Case report and literature review
DOI:
https://doi.org/10.33448/rsd-v12i13.44532Keywords:
Sickle cell trait; Blood protein electrophoresis; Hemoglobin sickle; Protein biosynthesis; Mutation.Abstract
Introduction: Sickle cell trait is an inherited disease characterized by haemolytic anemia associated with a defect in the biosynthesis of the hemoglobin molecule. It is an autosomal recessive disease, manifesting as chronic haemolytic anemia, with episodes of recurrent pain and cardiovascular complications and functional asplenia. Objective: analyze the case of a middle aged adult with a chance finding of sickle cell trait S and review current literature on the disease to discuss the clinical implications and medical recommendations related to the pathology. Methodology: the case report focused on providing a description of the disorder associated with qualitative defects in hemoglobin synthesis. It was a descriptive, exploratory and observational study. Case report: 45 year old male, consulted for blunt trauma to the right testicle with a hand passer. A routine haemogram was requested which showed low hemoglobin levels associated with idiopathic anemic syndrome. An ESP was requested in which moderate poikilocytosis suggestive of haemoglobinopathy was observed, and hemoglobin electrophoresis in alkaline medium was performed, resulting in an electrophoretic pattern suggestive of sickle cell trait. Discussion: It is important that people with sickle cell trait follow medical recommendations, such as genetic diagnosis, regular medical follow-up, vaccination against infections and keeping informed about the disease. Conclusion: Haemoglobinopathies represent a public health problem. Patients can reach adulthood with an acceptable quality of life, unfortunately there are limitations in our environment.
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Copyright (c) 2023 Diego Fernando Lopez Muñoz; Jose Francisco Gonzalez Rivera; Melissa Moreno Sanchez; Juan José Quintero González ; Dayil Yurani Ramirez Herrera; Karen Yulieth Diaz Duarte; Camilo Alexis Arellano Genoy
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