Comparison of the diagnostic efficacy between urease and histopathological tests in H. pylori
DOI:
https://doi.org/10.33448/rsd-v13i1.44822Keywords:
Infection; Diagnosis; Helicobacter pylori.Abstract
- pylori infection is globally prevalent, varying by age, geographic location, and socioeconomic status. In Brazil, it is estimated that it affects around 70% of the population, increasing with age and being lower in the white population, regardless of sex. The objective of this study was to compare the results of histopathological and urease tests in patients, highlighting a higher positivity in the former (42%) compared to previous studies. The analysis of age groups revealed a higher prevalence of positive H. pylori in patients between 30-39 years old, differing from other studies. Regarding gender, a higher incidence was observed in males (47%), similar to previous studies. Dyspeptic symptoms were observed in 48% of patients, but were not directly correlated with H. pylori positivity. Regarding clinical variables, the majority of patients did not have drug allergies (76%) or significant comorbidities, and among those who had comorbidities, systemic arterial hypertension was the most prevalent (73.7%). Clinical tests, especially urease and histopathology, were compared, showing similar results, although the urease test has been suggested as useful in ruling out infection when negative. It is concluded that the combination of both methods can be beneficial. This study contributes to the understanding of the prevalence of H. pylori, highlighting the importance of joint assessment of diagnostic tests and the need for more research on correlations with specific clinical variables.
References
Bittencourt, P. F., Rocha, G. A., Penna, F. J., & Queiroz, D. M. M. (2006). Gastroduodenal pepti culcer and Helicobacter pylori infection in children and adolescents. J Pediatr., 82(5), 325-334. https://pubmed.ncbi.nlm.nih.gov/17003940/
Borges, S. S., Ramos, A. F. P. L., Moraes Filho A.V., Braga, C. A. S. B., Carneiro, L. C., & Barbosa, M. S. P. (2019). Prevalência da infecção por Helicobacterpylori em pacientes dispépticos e associação com fatores de riscos clínicos para o desenvolvimento de adenocarcinoma gástrico. ArqGastroenterol., 56(1), 66-70. doi: http://dx.doi.org/10.1590/ s0004-2803.201900000-03.
Camiña, H. C., Matos, D. B., Bombarda, G. B, & Foiatto, W. M. (2017). Comparação entre teste da urease e histopatologia na identificação do Helicobacter pylori. GED gastroenterol. endosc. dig., 36(1), 1-6. https://docs.bvsalud.org/biblioref/2017/05/833536/comparacao-teste-urease.pdf
Caetano, A., Felix, V. N., Coimbra, F. T. V., & Ganc, A. J. (2008). Helicobacterpylori e doença péptica. Estudo comparativo de métodos diagnósticos. ArqGastroenterol., 45(3), 255-257. https://www.scielo.br/j/ag/a/RJyZpvzgGZWgnWZbHgrg5wd/abstract/?lang=pt
Correa, P.; & Piazuelo, M. B. (2008). Natural history of Helicobacter pylori infection. Dig LiverDis. 40(7), 490-6. https://pubmed.ncbi.nlm.nih.gov/18396115/
Dietz, J. et al. (2001). Helicobacter pylori: estudo comparativo entre técnicas diagnósticas invasivas. GED, Gastroenterol. Endosc. Digest., 20(2), 36-40. file:///Users/jorgecorreianeto/Downloads/4473-Texto%20do%20Artigo-11322-1-10-20100730.pdf
Guimarães, J., Corvelo, T. C., & Barile, K. A. (2008). Helicobacterpylori: fatores relacionados à sua patogênese. Ver. Para. Med. 22(1). http://scielo.iec.gov.br/scielo.php?script=sci_arttext&pid=S0101-59072008000100005
Hosseininasab, S. A., & Nabavi, A. (2019). Interaction of Helicobacter pylori Infection and Type 2 Diabetes Mellitus. Adv Biomed Res. 8(15), 15. http://dx.doi.org/10.4103/abr.abr_37_18. PMid:30993085
Ladeira, M. S., Salvadori, D. M., & Rodrigues, M. A. (2003). Biopatologia do Helicobacter pylori. J Bras Patol Med Lab. ;39(4), 335-42. https://doi.org/10.1590/S1676-244420030004
Lu, C. L., Chang, F. Y., Chen, T. S., Chen, C. Y., Jiun, K. L., & Lee, S. D. (1998). Helicobacter pylori colonization does not influence the symptomatic response to prokinetic agents in patients with functional dyspepsia. J. Gastroenterol Hepatol. 13, 500-4. https://pubmed.ncbi.nlm.nih.gov/9641648/
Machida-montani, A., Sasasuki, S., Inoue, M., Natsukawa, S., Shaura, K., & Koizumi, Y. (2004). Association of Helicobacterpylori infection and environmental factors in non-cardiagastriccancer in Japan. GastricCancer., 7(1), 46-56. https://pubmed.ncbi.nlm.nih.gov/15052440/
Neto, D. J. S., Goncalves, L. M., Castro, V. L., & Guimaraes, A. O. (2020). Acurácia diagnóstica entre teste rápido da urease e estudo histopatológico para detecção de Helicobacterpylori. RevSocBras Clin Med. 18(4), 196-199. https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1361597
Ornellas, L.C., Cury, M. S., Lima, V. M., & Ferrari, A. P. (2000). Avaliação do teste rápido da urease conservado em geladeira. ArqGastroenterol. 37(3), 155-157. https://www.scielo.br/j/ag/a/yjKbX5G4vMKMBJDgLZdtRHn/
Parente, J. M., & Parente, M. P. (2010). Contexto epidemiológico atual da infecção por Helicobacterpylori. GED GastroenterolEndosc Dig., 29(3), 86-89. https://pesquisa.bvsalud.org/portal/resource/pt/lil-590955
Parente, J. M. L., Mendes, C. M. M., Ramos, C. V., Medeiros, T. S. G., & Salgado, J. E. A. (2023). Infecção por helicobacterpylori: Revisão integrativa. Revista eletrônica Acervo saúde, 23(6), 1-11. file:///Users/jorgecorreianeto/Downloads/12876-Artigo-155976-1-10-20230626.pdf
Silva, E. A. W. (2014). Estudo do Helicobacter pylori na mucosa gástrica: história clínica, endoscopia digestiva alta, exame anatomopatológico e resposta imune. Universidade de Uberaba. https://repositorio.uniube.br/handle/123456789/669
Siqueira, J. S., Lima, P. S.S., Barreto, A. S., & Quintans- Junior, L. J. (2007). Aspectos Gerais nas Infecções por Helicobacterpylori – Revisão. RBAC, 39(1)9-13. https://pesquisa.bvsalud.org/portal/resource/pt/lil-461284
Tenório, P. P., & Melo, M. R. (2009). Correlação entre a histopatologia e teste da urease para pesquisa de H. pylori em pacientes portadores de gastrite. R. Ci. Méd. Biol. 8(3), 301-306. https://periodicos.ufba.br/index.php/cmbio/article/view/4473
Vargas, L. J., et al. (2019). Diagnostic methods of detection of h.pylori infection: systematic review. Para Res Med J. 3(2). https://pubmed.ncbi.nlm.nih.gov/28456631/
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Jéssica Seibert dos Santos; Natália Rocha de Aguiar
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
