SYNTAX score and microalbuminuria in patients with acute coronary syndrome

Authors

DOI:

https://doi.org/10.33448/rsd-v13i2.44996

Keywords:

Albuminuria; Acute coronary syndrome; Coronary artery disease.

Abstract

Objectives: The present study aims to evaluate microalbuminuria (MAU) in non-diabetic patients with acute coronary syndrome (ACS) admitted to the Hospital Universitário Maria Aparecida Pedrossian, undergoing invasive risk stratification through coronary cineangiocardiography, correlating its dosage with the severity of coronary lesions calculated by the SYNTAX score. Methodology: Observational, prospective study, including non-diabetic patients, over 18 years of age, with ACS, undergoing urine collection for MAU measurement before cardiac catheterization or within 24 hours of hospital admission, during the period from May to December 2023. Patients with a filtration rate below 30 mL/min/1.73 m² and previously undergoing percutaneous coronary intervention or myocardial revascularization were excluded from the study. Results: 20 patients were analyzed, 55% male with a mean age of 61.2 years (± 12.6). Systemic arterial hypertension and dyslipidemia were the most prevalent comorbidities (65%). Acute myocardial infarction (AMI) without ST-segment elevation and AMI with ST-segment elevation were responsible for 80% of patients with ACS. The highest prevalence of coronary vessel involvement was single vessel and triple vessel, each corresponding to 30%, and the average SYNTAX calculated was 12 (± 13.2). The mean MAU value was 197.4 (negative) and the correlation between SYNTAX and MAU rates was not significant (p=0.112; r=-0.377). Conclusion: No statistically relevant relationship was observed between MAU values and the severity of coronary lesions calculated by the SYNTAX score.

References

Abela, O. G., Ahsan, C. H., Alreefi, F., Salehi, N., Baig, I., Janoudi, A., & Abela, G. S. (2016). Plaque Rupture and Thrombosis: the Value of the Atherosclerotic Rabbit Model in Defining the Mechanism. Current atherosclerosis reports, 18(6), 29. https://doi.org/10.1007/s11883-016-0587-0

Al-Saffar, H. B., Nassir, H., Mitchell, A., & Philipp, S. (2015). Microalbuminuria in non-diabetic patients with unstable angina/non ST-segment elevation myocardial infarction. BMC research notes, 8, 371. https://doi.org/10.1186/s13104-015-1347-x

Aminuddin, A., Cheong, S. S., Roos, N. A. C., & Ugusman, A. (2023). Smoking and Unstable Plaque in Acute Coronary Syndrome: A Systematic Review of The Role of Matrix Metalloproteinases. International journal of medical sciences, 20(4), 482-492. https://doi.org/10.7150/ijms.79889

Bruno, T. C., Bittencourt, M. S., Quidim, A. V. L., Santos, I., Lotufo, P., Bensenor, I., & Goulart, A. (2021). The Prognosis of Coronary Artery Disease in a Brazilian Community Hospital: Findings from the ERICO Study. O Prognóstico da Doença Arterial Coronariana em um Hospital Público no Brasil: Achado do Estudo ERICO. Arquivos brasileiros de cardiologia, 117(5), 978–985. https://doi.org/10.36660/abc.20200399

Cardoso, M. R., Silva Junior, D. G., Ribeiro, E. A., Rocha Neto, A. M. (2018). Correlation Between the Complexity of Coronary Lesions and High-Sensitivity Troponin Levels in Patients with Acute Coronary Syndrome. International Journal of Cardiovascular Sciences, 31(3), 218-225. https://doi.org/10.5935/2359-4802.20180014

Estrela, C. (2018). Metodologia Científica: Ciência, Ensino, Pesquisa. Editora Artes Médicas.

Hao, G., Wang, Z., Zhang, L., Chen, Z., Wang, X., Guo, M., Tian, Y., Shao, L., & Zhu, M. (2015). Prevalence of microalbuminuria among middle-aged population of China: a multiple center cardiovascular epidemiological study. Angiology, 66(1), 49–56. https://doi.org/10.1177/0003319713513144

Hillege, H. L., Janssen, W. M., Bak, A. A., Diercks, G. F., Grobbee, D. E., Crijns, H. J., Van Gilst, W. H., De Zeeuw, D., De Jong, P. E., & Prevend Study Group (2001). Microalbuminuria is common, also in a nondiabetic, nonhypertensive population, and an independent indicator of cardiovascular risk factors and cardiovascular morbidity. Journal of Internal Medicine, 249(6), 519–526. https://doi.org/10.1046/j.1365-2796.2001.00833.x

Khalil et al. (2021). Microalbuminuria as a Predictor of Outcome in Non-Diabetic Patients Undergo Percutaneous Coronary Intervention for Acute Coronary Syndrome. The Egyptian Journal of Hospital Medicine, 85(2), 4284-4289-4284. https://www.ajol.info/index.php/ejhm/article/view/223664.

Kumar Jha, P., Ete, T., Malviya, A., Kumar Das, C., Saha, S. K., Nath, D., Kapoor, M., & Mishra, A. (2017). Microalbuminuria: Correlation With Prevalence and Severity of Coronary Artery Disease in Non-Diabetics. Journal of clinical medicine research, 9(10), 838–843. https://doi.org/10.14740/jocmr2785w

Paul, L., Anil Kumar, C. R., Francis, S., Ravi, M. (2018). Role of Microalbuminuria as a Predictor of Severity of Coronary Artery Disease - A Prospective Cohort Study. JMSCR. https://dx.doi.org/10.18535/jmscr/v6i3.128

Mahmoud, H. T., Berton, G., Cordiano, R., Palmieri, R., Petucco, S., & Bagato, F. (2023). Microalbuminuria during acute coronary syndrome: Association with 22-year mortality and causes of death. The ABC-8* study on heart disease. (*ABC is an acronym for Adria, Bassano, Conegliano, and Padova Hospitals). International Journal of Cardiology, 374, 100–107. https://doi.org/10.1016/j.ijcard.2022.12.025

Mok, Y., Ballew, S. H., Sang, Y., Grams, M. E., Coresh, J., Evans, M., Barany, P., Ärnlöv, J., Carrero, J. J., & Matsushita, K. (2019). Albuminuria as a Predictor of Cardiovascular Outcomes in Patients With Acute Myocardial Infarction. Journal of the American Heart Association, 8(8), e010546. https://doi.org/10.1161/JAHA.118.010546

Mustafa, A. (2020). Study of microalbuminuria in non-diabetic and non-hypertensive patients with acute myocardial infarction. International Journal of Contemporary Medical Research, 7(3):C1-C3. http://dx.doi.org/10.21276/ijcmr.2020.7.3.28.

Namashivayam Shanmugasundram & Raja Ponnusamy. (2019). A study of prevalence of microalbuminuria in non-diabetic nonhypertensive coronary artery disease. IAIM, 2019; 6(4): 31-35. https://imsear.searo.who.int/items/2efc4b23-9747-45d8-827d-bd2a743bb84f.

Paudel, Navaraj et al. (2019). Profile of non-diabetes patients with microalbuminuria in acute coronary syndrome: a hospital-based study. Nepalese Heart Journal, 16(2), 63-67. DOI:10.3126/njh.v16i2.26320

Razavi, A., Dzaye, O., Michos, E. et al. (2024). Nontraditional Risk Markers for Incident Coronary Artery Calcium Among Persons ≥65 Years of Age. JACC Adv, 3 (2). https://doi.org/10.1016/j.jacadv.2023.100755

Ribeiro, A. L., Duncan, B. B., Brant, L. C., Lotufo, P. A., Mill, J. G., & Barreto, S. M. (2016). Cardiovascular Health in Brazil: Trends and Perspectives. Circulation, 133(4), 422–433. https://doi.org/10.1161/CIRCULATIONAHA.114.008727

Shah P. K. (2014). Biomarkers of plaque instability. Current cardiology reports, 16(12), 547. https://doi.org/10.1007/s11886-014-0547-7

Shuvy, M., Zwas, D. R., Lotan, C., Keren, A., & Gotsman, I. (2020). Albuminuria: Associated With Heart Failure Severity and Impaired Clinical Outcomes. The Canadian journal of cardiology, 36(4), 527–534. https://doi.org/10.1016/j.cjca.2019.09.001

Soeiro, A. M., Silva, P. G. M. B., Roque, E. A. C., Bossa, A. S., Biselli, B., Leal, T. C. A. T., Soeiro, M. C. F. A., Pitta, F. G., Serrano Jr., C. V., Oliveira Jr., M. T. (2018). Prognostic Differences between Men and Women with Acute Coronary Syndrome. Data from a Brazilian Registry. Arq Bras Cardiol, 111(5):648-653. https://doi.org/10.5935/abc.20180166

Sukhija, R., Aronow, W. S., Kakar, P., Garza, L., Sachdeva, R., Sinha, A., & Mehta, J. L. (2006). Relation of microalbuminuria and coronary artery disease in patients with and without diabetes mellitus. The American journal of cardiology, 98(3), 279–281. https://doi.org/10.1016/j.amjcard.2006.01.098

Taskiran, M., Iversen, A., Klausen, K., Jensen, G. B., & Jensen, J. S. (2010). The association of microalbuminuria with mortality in patients with acute myocardial infarction. A ten-year follow-up study. Heart international, 5(1), e2. https://doi.org/10.4081/hi.2010.e2

Wang, Y., Yuan, A., & Yu, C. (2013). Correlation between microalbuminuria and cardiovascular events. International journal of clinical and experimental medicine, 6(10), 973–978. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832337/.

Published

09/02/2024

How to Cite

PRESSUTO, K. M. de A.; SILVA JUNIOR, D. G. da .; ROCHA NETO, A. M. da .; MARQUES NETO, A. SYNTAX score and microalbuminuria in patients with acute coronary syndrome. Research, Society and Development, [S. l.], v. 13, n. 2, p. e3113244996, 2024. DOI: 10.33448/rsd-v13i2.44996. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/44996. Acesso em: 12 may. 2024.

Issue

Section

Health Sciences