Hepatic inflammatory pseudotumor in childhood: A case report
DOI:
https://doi.org/10.33448/rsd-v14i10.49569Keywords:
Hepatic pseudotumor, Hepatic abscess, Hepatic nodule, Benign tumor.Abstract
Inflammatory pseudotumor of the liver (PIF) presents as a type of rare, benign lesion, without neoplastic characteristics, and may arise from an exacerbated inflammatory response to some form of aggression, such as infections, trauma, or autoimmune conditions, and in some situations, can mimic malignant tumors, leading to a complex diagnosis, often late and differentiated. Clinically, it may present as a hepatic mass or hepatic abscess, which complicates the initial diagnosis. Thus, the final diagnosis requires histopathological examination and biopsy, as its conclusive study can resemble other types of liver lesions. Objective: To report a case of a 12-year-old patient, previously healthy, with fever for 11 days, associated with vomiting, abdominal pain in the right hypochondrium, initially to clarify until his diagnosis of inflammatory pseudotumor of the liver and clinical outcome. Methods: The data were obtained through electronic medical records and printed. The study was approved by the Research Ethics Committee at the hospital of origin and authorized by the legal guardians through the Informed Consent Form (ICF). This is an observational and descriptive study, without a control group, in the format of a clinical case report. Results/Conclusion: The pseudotumor should be considered in the differential diagnosis of any liver lesion, as initial examinations lead to suspicion of neoplastic conditions.
References
Balabaud, C., Bioulac-Sage, P., Goodman, Z. D. & Makhlouf, H. R. (2012). Inflammatory pseudotumor of the liver: a rare but distinct tumor-like lesion. Gastroenterol Hepatol (N Y). 8, 633–4.
Calistri, L. et al. (2022). Magnetic resonance imaging of inflammatory pseudotumor of the liver: a 2021 systematic literature update and series presentation. Abdominal Radiology. 47, 2795–810.
Calomeni, G. D., Ataíde, E. B., Machado, R. R., Escanhoela, C. A., Costa, L. B. & Boin, I. F. (2013). Hepatic inflammatory pseudotumor: A case series. Int J Surg Case Rep. 4, 308–11.
Conceição J.S., Santos A. M., Fonseca Junior L. E., Braga H. J. V., Silva L. R. Pseudotumor nflamatorio do Fígado - Um diagnostico diferencial raro de massa Hepatica: um relato de caso. 2012: 31(3), 102-106.
Chang, S. D., Scali, E. P., Abrahams, Z., Tha, S. & Yoshida, E. M. (2014). Inflammatory pseudotumor of the liver: a rare case of recurrencfollowing surgical resection. J Radiol Case Rep. 8, 23-30. https://doi.org/10.3941/jrcr.v8i3.1459.
Deng, F. T., Li, Y. X., Ye, L., Tong, L., Yong, X. P. & Chai, X. Q. (2010). Hilar inflammatory pseudotumor mimicking hilar cholangiocarcinoma. Hepatobiliary Pancreat Dis Int. (9), 219-21.
Geramizadeh, B., Tahamtan, M. R., Sefi dbakht, S., Madjolal, M.. Nabai, S. & Hosseini, S. A. M. (2009). Infl ammatory pseudotumor of the liver: two case reports and a review of the literature. Indian Pathol Microbiol. 52(2), 210-212.
Goldsmith, P. J., Loganathan, A., Jacob, M., Ahmad, N., Toogood, G. J., Lodge, J. P. & Prasad, K. R. (2009). Inflammatory pseudotumours of the liver: a spectrum of presentation and management options. Eur J Surg Oncol. 35, 1295–8. d oi: 10.1016/j.ejso.2009.04.003.
Ichikawa, S., Motosugi, U., Suzuki, T., Shimizu, T. & Onishi, H. (2020). Imaging features of hepatic inflammatory pseudotumor: distinction from colorectal liver metastasis using gadoxetate disodiumenhanced magnetic resonance imaging. Abdom Radiol. 45, 2400-8.
Jeong, J. Y., Sohn, J. H., Kim, T. Y., Jeong, W. K., Kim, J., Pyo, J. Y. et al. (2012). Hepatic inflmammatory pseudotumor misinterpreted as hepatocellular carcinoma. Clin Mol Hepatol. 18, 239-44.
Kawaguchi, T., Mochizuki, K., Kizu, T., Miyazaki, M., Yakushijin, T., Tsutsui, S. et al. (2012). Inflammatory pseudotumor of the liver and spleen diagnosed by percutaneous needle biopsy.World J Gastroenterol. 18(1), 90-5.
Milias, K., Madhavan, K. K., Bellamy, C., Garden, O. J. & Parks, R. W. (2009). Inflammatory pseudotumors of the liver: experience of a specialist surgical unit. J Gastroenterol Hepatol. 24,1562–6.
Motojuku, M., Oida, Y., Morikawa, G., Hoshikawa, T., Nakamura, T., Tajima, T. et al. (2008). Inflammatory pseudotumor of the liver: Case report and review of literature. Tokai J Exp Clin Med. 33,70-4.
Ntinas, A., Kardassis, D., Miliaras, D., Tsinoglou, K., Dimitriades, A. & Vrochides, D. (2011). Inflammatory pseudotumor of the liver: a case report and review of the literature. J Med Case Rep. 5,196.
Park, J. Y., Choi, M. S., Lim, Y. S., Park, J. W., Kim, S. U., Min, Y. W., Gwak, G. Y., Paik, Y. H., Lee, J. H., Koh, K. C., Paik, S. W. & Yoo, B. C. (2014). Clinical features, image findings, and prognosis of inflammatory pseudotumor of the liver: a multicenter experience of 45 cases. Gut Liver 2014; 8, 58-63
Patnana, M., Sevrukov, A. B., Elsayes, K. M., Viswanathan, C., Lubner, M. & Menias, C. O. (2012). Inflammatory pseudotumor: the great mimicker. AJR Am J Roentgenol. 198, W217-W227
Pereira, A. S. et al. (2018). Metodologia da pesquisa científica. [free ebook]. Santa Maria. Editora da UFSM.
Raquel M., Marta J., João S., Catarina F., António A..Pseudotumor Inflamatório do Fígado Relacionado A IGG4: Particularidades de um Diagnóstico Raro: caso clínico. Revista da Sociedade Portuguesa da Medicina Interna – 25(1), jan/mar 2018.
Rosa, B., Moutinho-Ribeiro, P., Pereira, J. M., Fonseca, D., Lopes, J., Amendoeira, I. et al. (2012). Ghost tumor: An Inflammatory Pseudotumor of the Liver. Gastroenterol Hepatol (NY). 8:630-3.
Sedlic, T., Scali, E. P., Lee, W. K., Verma, S. & Chang, S. D. (2014). Inflammatory pseudotumors in the abdomen and pelvis: a pictorial essay. Can Assoc Radiol J. 65, 52-9. https://doi. org/ 10. 1016/j. carj. 2013.02.003.
Shibata, M., Matsubayashi, H., Aramaki, T., Uesaka, K., Tsutsumi, N., Sasaki, K., et al. (2016). A case of IgG4-related hepatic inflammatory pseudotumor replaced by an abscess after steroid treatment. BMC Gastroenterol. 16, 89.
Soares M, Honovar M, Pimentel Barbosa J Pseudotumor inflamatório do fígado: o imitador bom das neoplasias hepáticas. Galicia Clin 2014; 75 (1), 36-38.
Tang, L., Lai, E. C., Cong, W. M., Li, A. J., Fu, S. Y., Pan, Z. Y., Zhou, W. P., Lau, W. Y. & Wu, M. C. (2010). Inflammatory myofibroblastic tumor of the liver: a cohort study. World J Surg. 34, 309–13.
Weiss, G. A., Shor, D. B. & Shachter, P. (2017). Inflammatory Pseudotumor of the Liver: An Unlikely Cause of Multiple Hepatic Lesions. IMAJ.
Yang, X., Zhu, J., Biskup, E., Cai, F. & Li, A. (2015). Inflammatory pseudotumors of the liver: experience of 114 cases. Tumour Biol. 36, 5143–8.
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