Use of exosomes containing polydeoxyribonucleotide (PDRN) in facial aesthetics. Clinical case report
DOI:
https://doi.org/10.33448/rsd-v14i10.49790Keywords:
Exosomes, Facial aesthetics, Microneedling.Abstract
The search for effective and regenerative aesthetic treatments has driven the use of exosomes in dermatological procedures. This study aims to present a case report demonstrating the application and results of the use of exosomes containing PDRN in facial aesthetics. A patient underwent microneedling associated with the application of exosomes with PDRN for facial rejuvenation. Three intervention sessions were performed at 30-day intervals, using a standardized intradermotherapy protocol. The results showed improvement in skin quality, with increased vitality, reduction of fine lines, and more uniform texture. The study suggests that PDRN-containing exosomes represent a promising strategy in regenerative aesthetics, although further studies are needed to consolidate their clinical efficacy.
References
Chernoff, G. (2021). The utilization of human placental mesenchymal stem cell derived exosomes in aging skin: An investigational pilot study. Journal of Surgery, 6, Article ID 1388. https://doi.org/10.29011/2575-9760.001388.
Couch, Y. et al. (2021). A brief history of nearly EV-erything – The rise and rise of extracellular vesicles. Journal of Extracellular Vesicles, 10(14), e12144. https://doi.org/10.1002/jev2.12144.
Estrela, C. (2018). Metodologia científica: Ciência, Ensino, Pesquisa. Editora Artes Médicas.
Gao, W., et al. (2018). Pterocarpus santalinus L. regulated ultraviolet B irradiation-induced procollagen reduction and matrix metalloproteinases expression through activation of TGF-β/Smad and inhibition of the MAPK/AP-1 pathway in normal human dermal fibroblasts. Photochemistry and Photobiology, 94(1), 139–149.
Gurung, S., et al. (2021). The exosome journey: From biogenesis to uptake and intracellular signalling. Cell Communication and Signaling, 19(1), 47.
Ho, C. Y., & Dreesen, O. (2021). Faces of cellular senescence in skin aging. Mechanisms of Ageing and Development, 198, 111525. https://doi.org/10.1016/j.mad.2021.111525
Johnstone, R. M., Adam, M., Hammond, J. R., Orr, L. & Turbide, C. (1987). Formação de vesículas durante a maturação de reticulócitos: Associação de atividades de membrana plasmática com vesículas liberadas (exossomos). Journal of Biological Chemistry. 262, 9412–20.
Lee, Y. I., et al. (2022). Cellular senescence and inflammaging in the skin microenvironment. International Journal of Molecular Sciences, 22(8), 3849.
Miller, J., Chen, G., & Hayag, M. V. (2023). A review of exosomes in regenerative cosmetic dermatology. Molecular Frontiers Journal, 7(1-2), 64–70.
Murphy, D. E. et al. (2019). Extracellular vesicle-based therapeutics: Natural versus engineered targeting and trafficking. Experimental & Molecular Medicine, 51(3), 1–12.
Ng, K. W. (2018). Penetration enhancement of topical formulations. Pharmaceutics, 10(2), 51. https://doi.org/10.3390/pharmaceutics10020051.
Olumesi, K. R. & Goldberg, G. J. (2023). A review of exosomes and their application in cutaneous medical aesthetics. Cosmetic Dermatology, 22(10), 2628–34.
Park, G. H. et al. (2023). Efficacy of combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling for facial skin aging: A 12-week prospective, randomized, split-face study. Journal of Cosmetic Dermatology, 22(12), 3418–3426.
Pereira, A. S. et al. (2018). Metodologia da pesquisa científica. [free ebook]. Santa Maria. Editora da UFSM.
SaludDerma. (n.d.). SaludDerma Brasil – Exossomos – EXOXE. Instagram: @Saludderma.br. https://www.instagram.com/saludderma.br/
Su, J. L. et al. (2022). Effect of human decidua mesenchymal stem cells-derived exosomes on the function of high glucose-induced senescent human dermal fibroblasts and its possible mechanism. Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi, 38(2), 170–83.
Toassi, R. F. C. & Petry, P. C. (2021). Metodologia científica aplicada à área da Saúde. (2.ed). Editora da UFRGS.
Wu, J. Y. et al. (2022). Stem cell-derived exosomes: A new method for reversing skin aging. Tissue Engineering and Regenerative Medicine, 19(5), 961–968.
Xiao, X. et al. (2021). Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src. Signal Transduction and Targeted Therapy, 6(1), 354.
Zheng, J. et al. (2024). Applications of exosomal miRNAs from mesenchymal stem cells as skin boosters. Biomolecules, 14(4), 459.
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Copyright (c) 2025 Ana Paula Pereira da Silva, Ana Paula Almeida das Virgens, Paula Cristina Bolonhez Cabeda, José Ricardo de Albergaria-Barbosa, Renato Assis Machado, Célia Marisa Rizzatti-Barbosa

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