Collagen biostimulation and anti-inflammatories: Synergistic or antagonistic effects?
DOI:
https://doi.org/10.33448/rsd-v14i11.49837Keywords:
Collagen, Anti-inflammatory, Calcium hydroxyapatite, Poly-L-Lactic acid, Skin.Abstract
Objective: To critically analyze scientific publications on the use of anti-inflammatory drugs concomitantly with collagen biostimulators and their effects on neocollagenesis, seeking to clarify whether there is interference in the neocollagenesis process and what are the best clinical practices to safely enhance therapeutic results. Methodology: A review was conducted in the PubMed, SciELO, Medline, and LILACS databases, using the keywords "collagen," "anti-inflammatory," "calcium hydroxyapatite," "poly-L-lactic acid," and "skin." Scientific articles in Portuguese, English, and Spanish that addressed the relationship between anti-inflammatory drugs and collagen biostimulators were included. Results and Discussion: The reviewed studies indicate that non-steroidal anti-inflammatory drugs (NSAIDs) can negatively interfere with the initial inflammatory phase, which is essential for the action of biostimulators. This interference can inhibit cell migration, angiogenesis, and tissue remodeling, reducing the formation of new collagen. On the other hand, symptoms such as pain, edema, and post-procedure discomfort justify, in some cases, the clinical use of these drugs, reinforcing the need for a careful and individualized assessment. Conclusion: The literature shows that the routine and indiscriminate use of anti-inflammatory drugs after the application of collagen biostimulators should be avoided, as it can compromise the inflammatory response necessary for neocollagenesis. Understanding the mechanisms of interaction between these substances is fundamental to maximizing clinical results and establishing safe and effective protocols.
References
Andrei, F. et al (2025). Unlocking the potential of collagen: A comprehensive review on its dermocosmetic benefits and applications. Brazilian Journal of Pharmaceutical Sciences. 61, e23983.
Bezerra, T. A. R. et al (2025). Recent Advances in Collagen Biostimulators for Facial Rejuvenation: A Systematic Review in Aesthetic Dermatology. Annals of Dermatological Science. 11(1).
Bortolozo, F., Menezes, H. S., Alves, D. D. & Mafaldo, R. C. (2021). Collagen biostimulator with polymethylmethacrylate. Indian J Appl Res. 11(4), 2249.
Bou-Gharios, G., Abraham, D. & Crombrugghe, B. (2020). Type I Collagen Structure, Synthesis, and Regulation. In Principles of Bone Biology. Amsterdã. 295–337.
Brandao-Rangel, M. A. R. et al (2022). Hydrolyzed Collagen Induces an Anti-Inflammatory Response That Induces Proliferation of Skin Fibroblast and Keratinocytes. Nutrients. 14(23), 4975.
Cervoni, E. (2024). Non-steroidal anti-inflammatory drugs may disrupt muscle and tissue repair. BMJ, 386 (33), q2030.
Chen, M. R. et al (2023). The effect of nonsteroidal anti-inflammatory drugs on tissue healing. Knee surgery, sports traumatology, arthroscopy. 21(3), 540-9.
Fuji, M. D. et al (2025). Effects of nonsteroidal antiinflammatory drugs on collagen biosynthesis of cultured chondrocytes. Rev Science Direct. 18(11), 16-8.
Grandi, C. S. (2023). Bioestimuladores de colágeno: uma revisão na literatura. Trabalho de conclusão de curso em Biomedicina. Anima Educação.
Júnior, J. C. M. & Suguihara, R. T. & Muknicka, D. P. (2023). Bioestimuladores de colágeno na harmonização orofacial. Research, Society and Development. 12 (7), e19912742716-e19912742716.
Ianhez, M. M. D. et al (2025). Complications of collagen biostimulators in Brazil: Description of products, treatments, and evolution of 55 cases. Journal of Cosmetic Dermatology. 23 (9), 2829-35.
Kisiel, M. A. et al (2019). Isolation and Culture of Human Dermal Fibroblasts. Methods in molecular biology. 1993, 71-8.
Liu, S. et al (2025). Hydroxyapatite microspheres encapsulated within hybrid hydrogel promote skin regeneration through the activation of Calcium Signaling and Motor Protein pathway, Bioactive Materials. 2 (50), 287-304.
Muscará, M. N. et al (2019). Wound collagen deposition in rats: effects of an NO-NSAID and a selective COX-2 inhibitor. British Pharmacological Society Journal. 129 (4), 681-6.
Naka, C. H. et al (2024). Collagen bio-stimulators in facial rejuvenation: A literature review. Research, Society and Development. 13 (10), e72131047095.
Pereira, F. F. et al (2021). Camadas da face e mudanças associadas ao envelhecimento facial. Ciência Estética Orofacial, 2 (2).
Pereira, A. S. (2018). Metodologia da pesquisa científica. [free ebook]. Santa Maria. Editora da UFSM.
Rodrigues, M. A. (2023). Bioestimuladores de colágeno na harmonização orofacial: uma revisão de literatura. Trabalho de Conclusão de curso Odontologia do Centro Universitário UniAteneu, Fortaleza.
Salvatore, L. et al. (2023). An Update on the Clinical Efficacy and Safety of Collagen Injectables for Aesthetic and Regenerative Medicine Applications. Polymers. 15 (4), 1020.
Santos, P. C. et al (2025). Bioestimuladores de colágeno na harmonização orofacial: uma revisão narrativa da literatura. Pesquisa, Sociedade e Desenvolvimento. 14 (2), e9014248291.
Snyder, H. (2019). Literature Review as a Research Methodology: An Overview and Guidelines. Journal of Business Research, 104, 333-339. https://doi.org/10.1016/j.jbusres.2019.07.039.
Sorushanova, A. et al (2019). The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development. Adv. Mater. 31, e1801651.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 João Victor Pessoa da Silva Lins, Sophie Barbosa de Farias Gama, Joyce da Silva, Anderson de Oliveira Rocha, Sidney Acioly de Albuquerque Costa, Caroline Carnaúba Peixoto Rosário, Renata Elteque Lima de Oliveira Pereira
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
