Adhesion to healthy and caries-affected dentin: A comparative analysis

Authors

DOI:

https://doi.org/10.33448/rsd-v14i11.50021

Keywords:

Bonding, Healthy, Dentin, Endurance, Affected, Caries.

Abstract

Objective: To analyze and compare, through a literature review, the performance of adhesive systems on sound and caries-affected dentin, identifying the main factors that influence the quality and longevity of the bond on each substrate. Methodology: A narrative review was conducted based on publications indexed in Google Scholar, SciELO, PubMed, and Cochrane. Articles published in Portuguese and English in the last fifteen years that compared the adhesive performance between sound and caries-affected dentin were included. Results and discussion: The literature shows that the structural properties of dentin directly influence the efficiency of adhesive systems. In general, conventional etch-and-rinse adhesives and universal adhesives applied in the same way have demonstrated better performance on caries-affected dentin. However, the adhesive interface on this substrate is more vulnerable to hydrolytic degradation and the action of metalloproteinases (MMPs), which compromises the stability of the hybrid layer. The lack of effective chemical bonding between the adhesive and exposed collagen remains a limiting factor for the longevity of restorations. New research has emphasized the importance of strategies focused on enzyme inhibition and the use of bioinspired monomers capable of chemically interacting with collagen, promoting more durable interfaces. Conclusion: Selecting the adhesive strategy based on the conditions of the dentin substrate has considerable potential to transform restorative practice, promoting more durable and stable treatments.

References

Al-Obaidi, Z. S., & Jasim, H. H. (2023). Assessment of shear bond strength to sound and artificial caries affected dentin using different adhesive systems: An in vitro study. Dental Hypotheses, 14(1), 3-5. https://doi.org/10.4103/denthyp.denthyp_126_22

Drobac, M., Stojanac, I., Ramić, B., Premović, M., & Petrović, L. (2019). Shear bond strength to sound and caries-affected dentin of simplified "etch-and-rinse" and "self-etch" adhesives and the hybrid layer micromorphology. Vojnosanitetski Pregled, 76(7), 675-683. https://doi.org/10.2298/VSP161220146D.

Fontes, S. T., Lima, G. da S., Ogliari, F., Piva, E., & Moraes, R. R. de. (2012). Hybridization morphology and dentin bond stability of self-etch primers with different ethanol/water ratios. Odontology, 100(2), 181-186. https://doi.org/10.1007/s10266-011-0030-5

Ghajari, M. F., Ghasemi, A., Badiee, M., Abdolazimi, Z., & Baghban, A. A. (2019). Microshear bond strength of Scotchbond Universal Adhesive to primary and permanent dentin: A six-month in vitro study. Frontiers in Dentistry, 16(3), 173-180. https://doi.org/10.18502/fid.v16i3.1588

Govil, S. A., Asthana, G., & Sail, V. A. (2023). Bonding strategies to deal with caries-affected dentin using cross-linking agents: Grape seed extract, green tea extract, and glutaraldehyde - An in vitro study. Journal of Conservative Dentistry, 26(1), 108-112. https://doi.org/10.4103/jcd.jcd_485_22

Hu, Y., He, Y., Wang, D., Wei, Y., Xing, X., & Xiao, Y. (2025). Enhancing caries-affected dentin bonding with a mussel-inspired primer. Frontiers in Bioengineering and Biotechnology, 13, Article e1574562. https://doi.org/10.3389/fbioe.2025.1574562

Isolan, C. P. (2016). União adesiva à dentina sadia e dentina afetada por cárie [Tese de Doutorado, Universidade Federal de Pelotas].

Leal, F. B., Madruga, F. C., Prochnow, E. P., Lima, G. S., Ogliari, F. A., Piva, E., & Moraes, R. R. (2011). Effect of acidic monomer concentration on the dentin bond stability of self-etch adhesives. International Journal of Adhesion and Adhesives, 31(6), 571-574. https://doi.org/10.1016/j.ijadhadh.2011.05.008

Lennon, Á. M., Reich, N. S., Ferstl, G., Ebensberger, H., Hiller, K.-A., & Buchalla, W. (2024). Shear bond strength of adhesives placed following selective removal of red-fluorescing carious dentine in vitro. Caries Research, 58(1), 17-29. https://doi.org/10.1159/000534349

Lima, J. F. M. de, Wajngarten, D., Islam, F., Clifford, J., & Botta, A. C. (2018). Effect of adhesive mode and chlorhexidine on microtensile strength of universal bonding agent to sound and caries-affected dentins. European Journal of Dentistry, 12(4), 553-558. https://doi.org/10.4103/ejd.ejd_239_18

Meraji, N., Nekoofar, M. H., Yazdi, K. A., Sharifian, M. R., Fakhari, N., & Camilleri, J. (2018). Bonding to caries affected dentine. Dental Materials, 34(10), e236-e245. https://doi.org/10.1016/j.dental.2018.05.017

Moharam, L. M., Salem, H. N., Khadr, S., & Abdou, A. (2023). Evaluation of different decontamination procedures on bond strength to sound and caries affected dentin using "no-wait" universal adhesive. BMC Oral Health, 23, Article 638. https://doi.org/10.1186/s12903-023-03314-2

Mohanty, P. R., Mishra, L., Saczuk, K., & Łapińska, B. (2023). Optimizing adhesive bonding to caries affected dentin: A comprehensive systematic review and meta-analysis of dental adhesive strategies following chemo-mechanical caries removal. Applied Sciences, 13(12), Article e7295. https://doi.org/10.3390/app13127295

Müller, C., Rosa, G. C. da, Teixeira, G. S., Krejci, I., Bortolotto, T., & Susin, A. H. (2017). Efeito da dentina cariada na resistência adesiva de um sistema adesivo universal e um de condicionamento ácido total. Revista de Odontologia da UNESP, 46(5), 273-277. https://doi.org/10.1590/1807-2577.03917

Nakajima, M., Kunawarote, S., Prasansuttiporn, T., & Tagami, J. (2011). Bonding to caries-affected dentin. Japanese Dental Science Review, 47(2), 102-114. https://doi.org/10.1016/j.jdsr.2011.03.002

Neves, T. P. da C., Leandrin, T. P., Tonetto, M. R., Andrade, M. F., & Campos, E. A. de. (2017). Resistência de união à microtração de sistemas adesivos "condiciona-e-lava" de dois passos: efeito de diferentes tratamentos da superfície dentinária condicionada. Revista de Odontologia da UNESP, 46(3), 131-137. https://doi.org/10.1590/1807-2577.14016

Otake, S., Oishi, S., Ozaki, T., Ikeda, M., & Komada, W. (2022). Efeito do método de remoção da dentina afetada pela cárie na resistência de união da resina composta à dentina do canal radicular. Healthcare, 10(11), Article e2143. https://doi.org/10.3390/healthcare10112143

Pashley, D. H., Tay, F. R., Breschi, L., Tjäderhane, L., Carvalho, R. M., Carrilho, M., & Tezvergil-Mutluay, A. (2011). State of the art etch-and-rinse adhesives. Dental Materials, 27(1), 1-16. https://doi.org/10.1016/j.dental.2010.10.016

Pereira, A. S. et al. (2018). Metodologia da pesquisa científica. [free ebook]. Santa Maria. Editora da UFSM.

Pitts, N. B., Zero, D. T., Marsh, P. D., Ekstrand, K., Weintraub, J. A., Ramos-Gomez, F., Tagami, J., Twetman, S., Tsakos, G., & Ismail, A. (2017). Dental caries. Nature Reviews Disease Primers, 3, Article 17030. https://doi.org/10.1038/nrdp.2017.30

Rother, E. T. (2007). Revisão sistemática x revisão narrativa. Acta Paulista de Enfermagem. 20(2), 5-6.

Schiroky, P. R. (2016). Dentina afetada por cárie: Avaliação e desenvolvimento de adesivo experimental [Dissertação de Mestrado, Universidade Federal do Rio Grande do Sul].

Snyder, H. (2019). Literature review as a research methodology: An overview and guidelines. Journal of Business Research. 104, 333-9. Doi: https://doi.org/10.1016/j.jbusres.2019.07.039.

Published

2025-11-12

Issue

Section

Health Sciences

How to Cite

Adhesion to healthy and caries-affected dentin: A comparative analysis. Research, Society and Development, [S. l.], v. 14, n. 11, p. e83141150021, 2025. DOI: 10.33448/rsd-v14i11.50021. Disponível em: https://www.rsdjournal.org/rsd/article/view/50021. Acesso em: 5 dec. 2025.