Impact of anxiety and depression on the quality of life of cancer patients: A literature review
DOI:
https://doi.org/10.33448/rsd-v14i12.50392Keywords:
Anxiety, Depression, Quality of Life.Abstract
Cancer remains a major global Public Health challenge and is frequently accompanied by significant psychological distress throughout the disease trajectory. This literature review aimed to examine the relationship between anxiety, depression, and Health-Related Quality Of Life (HRQoL) in cancer patients, focusing on studies published between 2012 and 2019. Searches were conducted in SciELO, LILACS, and BIREME using descriptors related to quality of life, anxiety, depression, and neoplasms. Of the 51 studies initially identified, 12 met the inclusion criteria and were fully analyzed. Findings revealed that anxiety and depression are highly prevalent among cancer patients and are consistently associated with significant impairment in HRQOL, affecting physical, emotional, social, and cognitive domains. Evidence also indicates negative effects on treatment adherence, patient functioning, self-care, and clinical prognosis. Factors such as female sex, younger age, limited social support, chronic pain, and severe fatigue were identified as contributors to increased psychological vulnerability. The literature highlights the need for systematic screening of emotional symptoms and for integrating psychosocial and/or pharmacological interventions into oncology care. Early identification and appropriate management of anxiety and depression are essential to providing comprehensive care, reducing emotional distress, and improving quality of life for individuals living with cancer.
References
Aaronson, N. K., et al. (1993). The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument. Journal of the National Cancer Institute, 85(5), 365–376.
Brown, L. F., Kroenke, K., Theobald, D., & Wu, J. (2020). The association of depression and anxiety with health-related quality of life in cancer patients. Psycho-Oncology, 29(12), 1994–2002.
Caruso, R., et al. (2017). Anxiety and depression in cancer patients: Sociodemographic and clinical correlates. Supportive Care in Cancer, 25, 711–720.
Cella, D. F., et al. (1993). The Functional Assessment of Cancer Therapy scale: Development and validation. Journal of Clinical Oncology, 11(3), 570–579.
Greer, J. A., et al. (2018). Depression and adherence to cancer treatment. Journal of Clinical Oncology, 36(34), 3259–3265.
Henry, M., et al. (2018). Pain, fatigue, and mood in cancer patients: A longitudinal analysis. Pain Medicine, 19(2), 345–356.
Hinz, A., et al. (2019). Anxiety and depression in cancer patients across cancer types. Journal of Affective Disorders, 246, 464–471.
Li, M., et al. (2016). Social determinants and psychological distress in cancer patients. Psycho-Oncology, 25(8), 865–872.
Linden, W., Vodermaier, A., Mackenzie, R., & Greig, D. (2012). Anxiety and depression in cancer patients: Prevalence and risk factors. Journal of Clinical Oncology, 30(29), 3314–3320.
Matsuda, A., et al. (2014). Depression and HRQoL in cancer: A systematic review. Psycho-Oncology, 23(5), 564–579.
Mehnert, A., et al. (2018). One decade of research on mental health in oncology: A systematic review. Lancet Oncology, 19(12), e672–e683.
Mitchell, A. J., et al. (2011). Prevalence of depression in cancer: Meta-analysis. Lancet Oncology, 12(2), 160–174.
Pereira, A. S. et al. (2018). Metodologia da pesquisa científica. [Free ebook]. Santa Maria. Editora da UFSM.
Pitman, A., et al. (2018). Depression and anxiety in cancer patients: Epidemiology and management. BMJ, 361, k1415.
Satin, J. R., Linden, W., & Phillips, M. J. (2009). Depression and cancer mortality: A meta-analysis. Cancer, 115(22), 5349–5361.
Snyder, H. (2019). Literature review as a research methodology: An overview and guidelines. Journal of Business Research, Elsevier. 104(C), 333-9.
Sung, H., et al. (2021). Global cancer statistics 2020: GLOBOCAN estimates. CA: A Cancer Journal for Clinicians, 71(3), 209–249.
Winger, J. G., et al. (2017). Age-related differences in anxiety and depression in oncology. Supportive Care in Cancer, 25, 2479–2486.
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Copyright (c) 2025 Thiago Vaz de Andrade, Caio César Balthazar da Silveira Vidal, Luma Teles de Resende, Mylenna Menezes Leite Nascimento, Matheus Jhonnata Santos Mota, Luana Teles de Resende
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