Temporal trend of mortality from malignant neoplasm of the larynx in Brazil: Epidemiological analysis based on DATASUS data (1980-2019)
DOI:
https://doi.org/10.33448/rsd-v14i12.50418Keywords:
Laryngeal neoplasm, Mortality, Epidemiology, DATASUS, Brazil.Abstract
Objective: To analyze the temporal trend of mortality from malignant neoplasm of the larynx in Brazil and regions, using data from the Mortality Information System (SIM/DATASUS). Methodology: Descriptive epidemiological time series study, using secondary data from SIM/DATASUS for the period 1980-2019. A total of 112,693 deaths from malignant neoplasm of the larynx (ICD-10: C32; ICD-9: 161) were analyzed, stratified by sex, age group, geographic region and year of occurrence. Crude and age-adjusted mortality rates, temporal trend analysis and Annual Percent Change (APC) were calculated. Results: Male predominance was observed (87.3%; ratio 7.7:1), with concentration in the 60-69 years age group (31.4%). The Southeast region accounted for 49.0% of deaths. The temporal trend showed growth until 1999, followed by significant decline from 2000 onwards (APC 2009-2019: -1.6%). Adjusted rates decreased 38.7% between 2000-2019. Conclusion: Mortality from laryngeal cancer in Brazil shows a significant decreasing trend, reflecting the impact of tobacco control policies. Continuous monitoring is essential for evaluating public policies and guiding prevention strategies.
References
Antunes, J. L. F., & Cardoso, M. R. A. (2015). Uso da análise de séries temporais em estudos epidemiológicos. Epidemiologia e Serviços de Saúde, 24(3), 565–576. https://doi.org/10.5123/S1679-49742015000300024
Bosetti, C., Bertuccio, P., Malvezzi, M., Levi, F., Chatenoud, L., Negri, E., & La Vecchia, C. (2013). Cancer mortality in Europe, 2005–2009, and an overview of trends since 1980. Annals of Oncology, 24(10), 2657–2671. https://doi.org/10.1093/annonc/mdt301
Bottazzi, B., Riboli, E., & Mantovani, A. (2018). Aging, inflammation and cancer. Seminars in Immunology, 40, 74–82. https://doi.org/10.1016/j.smim.2018.10.011
Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. (2019). Sistema de Informações sobre Mortalidade – SIM.
Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. (2020). Vigitel Brasil 2019: Vigilância de fatores de risco e proteção para doenças crônicas por inquérito telefônico.
Cancela, M. C. (2007). O envelhecimento da população brasileira e o câncer: Um enfoque demográfico (Dissertação de mestrado). Escola Nacional de Ciências Estatísticas, IBGE.
Ferlay, J., Colombet, M., Soerjomataram, I., Mathers, C., Parkin, D. M., Piñeros, M., Znaor, A., & Bray, F. (2019). Global cancer observatory: Cancer today. International Agency for Research on Cancer. https://gco.iarc.fr
Instituto Nacional de Câncer José Alencar Gomes da Silva. (2020). Estimativa 2020: Incidência de câncer no Brasil. INCA.
Jorge, M. H. P. M., Laurenti, R., & Gotlieb, S. L. D. (2007). Análise dos dados de mortalidade. Revista de Saúde Pública, 41(Supl. 1), 5–13. https://doi.org/10.1590/S0034-89102007000800002
Marur, S., & Forastiere, A. A. (2016). Head and neck squamous cell carcinoma: Update on epidemiology, diagnosis, and treatment. Mayo Clinic Proceedings, 91(3), 386–396. https://doi.org/10.1016/j.mayocp.2015.12.017
Nascimento, E. G. S., Shitsuka, R., & Shitsuka, D. M. (2015). Um algoritmo baseado em técnicas de agrupamento para detecção de anomalias em séries temporais. In R. Shitsuka & D. M. Shitsuka (Orgs.), Estudos e práticas de aprendizagem de matemática e finanças com apoio de modelagem (pp. 155–186). Editora Ciência Moderna.
Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da pesquisa científica. Editora da UFSM.
Pinoborg, R. (1978). Tobacco and oral pathology. Journal of Dental Research, 57(3), 296–301. https://doi.org/10.1177/00220345780570030101
Ramroth, H., Dietz, A., & Becher, H. (2011). Laryngeal cancer risk in Germany decreased over time. European Journal of Cancer Prevention, 20(4), 312–318. https://doi.org/10.1097/CEJ.0b013e328345fbf5
Shitsuka, R., Shitsuka, D. M., & Silva, A. R. L. (2014). Matemática fundamental para tecnologia (2ª ed.). Editora Érica.
Steuer, C. E., El-Deiry, M., Parks, J. R., Higgins, K. A., & Saba, N. F. (2017). An update on larynx cancer. CA: A Cancer Journal for Clinicians, 67(1), 31–50. https://doi.org/10.3322/caac.21386
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