Use of additivies in diets for piglets in nursing stage: a review
DOI:
https://doi.org/10.33448/rsd-v9i12.11081Keywords:
Performance; Weaning; Prebiotics; Probiotics; Intestinal health.Abstract
The use of additives in diets for weaned piglets in industrial pig farming aims to reduce the use of antibiotics in this production, besides improving intestinal health and animal’s performance. Therefore, this study aimed to elaborate a bibliographic review on the main additives used in diets for piglets in the nursery phase. The additives acts as pro and prebiotics, which are essential in the nursery phase due to the health challenges that the animals are exposed, since they promote some health benefits for the animals. The success in the use of additives in the nursery phase is related to the dosage to be used and mainly to the challenges levels to which the animals are exposed. Some Research results in this area indicate that additives are more efficient in more challenged animals, which justifies the variability of results found in the literature. Other studies demonstrate that the additives action mechanism can reduce the use of antibiotic in the piglet’s diets in the nursery phase, in addition to adding better performance results regarding weight gain, feed consumption and feed conversion. According to the review carried out, it is concluded that the use of additives in piglets diets during the nursing period, can improve productive indexes of the animals, in addition to being taught as alternatives to the use of antibiotics.
References
Alvarenga, P. V. A. (2019). Prebióticos em substituição à antimicrobiano em dietas de leitões recém-desmamados. Tese (Doutorado) – Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Campus Botucatu. p. 27. Recuperado de: https://repositorio.unesp.br/handle/11449/181410.
Araújo, W. A. A., Brustolini, P. C., Ferreira, A. S., Silva, F. C. O., Abreu, M. L. T. & Lanna, E. A. (2011). Comportamento de leitões em função da idade de desmame. Revista Brasileira de Saúde e Produção Animal, 12(3), 758-769. Recuperado de: https://agris.fao.org/agris-search/search.do?recordID=BR2012500010.
Assis, S. D., Luna, U. V., Junior, J. C. G., Correa, G. S. S., Correa, A. B. & Brusamarelo, E. (2014). Desempenho e características morfo-intestinais de leitoas desmamadas alimentadas com dietas contendo associações de mananoligossacarídeo. Archives of Veterinary Science, 19(4), 33-41. Recuperado de: https://revistas.ufpr.br/veterinary/article/view/35581.
Associação Brasileira de Proteína Animal – ABPA. Relatório Anual, (2020). São Paulo-SP: ABPA. p. 160. Recuperado de: https://bit.ly/2tByYrP.
Barros, J. S. G., Rossi, L. A. & Sartor, K. (2015). PID temperature controller in pig nusery: improvements in performance, thermal comfort, and electricity use. International Journal of Biometeorology, 60(8), 1271-1277. Recuperado de: https://link.springer.com/article/10.1007/s00484-015-1122-7.
Bermudez-Brito, M., Plaza-Díaz, J., Muñoz-Quezada, S., Gómez-Llorente, C. & Gil, A. (2012). Probiotic Mechanisms of Action. Annual Nutrition and Metabolism, 61(2), 160-174. doi:10.1159/000342079.
BERTO, P. N. (2017). Suplementação dietética de levedura hidrolisada e seu efeito no desempenho, na microbiota intestinal e resposta imune dos leitões desmamados. Dissertação (Mestrado em Nutrição e Produção Animal), Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo. p. 54. Recuperado de: https://www.teses.usp.br/teses/disponiveis/10/10135/tde-01032018-105700/en.php.
Bezerra, W. G. A., Horn, R. H., Silva, I. N. G., Teixeira, R. S. C., Lopes, E. S., Albuquerque, Á. H. & Cardoso, W. C. (2017). Antibióticos no setor avícola: uma revisão sobre a resistência microbiana. Archivos de Zootecnia, 66(254), 301-307. doi:10.21071/az.v66i254.2335.
Biagi, G., Piva, A., Moschini, M., Vezzali, E. & Roth, F. X. (2007). Performance, intestinal microflora, and wall morphology of weanling pigs fed sodium butyrate. Journal of Animal Science, 85(5), 1184-1191. doi:10.2527/jas.2006-378.
Budiño, F. E. L., Prezzi, J. A., Rodrigues, D. J., Monfredini, R.P. & Otsuk, I. P. (2015). Desempenho e digestibilidade de leitões alimentados com rações contendo feno de alfafa e frutoligossacarídeo na fase inicial 1. Revista Brasileira de Saúde e Produção Animal, Salvador, 16(4), 796-810. doi:10.1590/S1519-99402015000400004.
Campbell, J. M., Crenshaw, J. D. & Polo, J. (2013). The biological stress of early-weaned piglets. Journal of Animal Science and Biotechnology, (19), 4. doi: 10.1186/2049-1891-4-19.
Cao, S., Wang, L., Jiao, L., Lin, F., Xiao, K. & Hu, C. (2016). Effects of diosmectite-Lactobacillus acidophilus on growth performance, intestine microbiota, mucosal architecture of weaned pigs. Animal Feed Science and Technolgy, 220, 180-186. doi:10.1016/j.anifeedsci.2016.08.012.
Che, L., Xu, Q., Wu, C., Luo, Y., Huang, X., Zhang, B., Auclair, E., Kiros, T., Fang, Z., Lin, Y., Xu, S., Feng, B., Li, J. & Wu, D. (2017). Effects of dietary live yeast supplementation on growth performance, diarrhoea severity, intestinal permeability and immunological parameters of weaned piglets challenged with enterotoxigenic Escherichia coli K88. British Jornal of Nutrition, 118(11), 949-958. doi:10.1017/S0007114517003051.
Chen, H., Hu, H., Chen, D., Tang, J., Yu, B.; Luo, J., He, J., Luo, Y., Yu, J. & Mao, X. (2017). Dietary pectic oligosaccharide administration improves growth performance and immunity in weaned pigs infected by rotavirus. Journal of Agricultural and Food Chemistry, 65(14), 2923-2929. doi: 10.1021/acs.jafc.7b00039.
Chen, J. L., Zheng, P., Zhang, C., Yu, B., He, J., Yu, J., Luo, J. Q., Mao, X. B., Huang, Z. Q. & Chen, D. W. (2017). Benzoic acid beneficially affects growth performance of weaned pigs, which was associated with changes in gut bacterial populations, morphology indices and growth factor gene expression. Journal of Animal Physiology and Animal Nutrition, 101(6), 1137–1146. doi:10.1111/jpn.12627.
Cho, J. H., Lee, S. I. & Kim, I. H. (2015). Effect of different levels of fibre and benzoic acid on growth performance, nutrient digestibility, reduction of noxious gases, serum metabolites and meat quality in finishing pigs. Journal of Applied Animal Research, 43(3), 336–344. doi:10.1080/09712119.2014.978772.
Costa, L., Berenchtein, B., Almeida, V., Tse, M., Braz, D., Andrade, C., Mourão, G. & Myada, V. (2011). Aditivos fitogênicos e butirato de sódio como promotores de crescimento de leitões desmamados. Archivos de Zootecnia, 60(231), 687-698. doi:10.4321/S0004-05922011000300056.
Cruz, A., Hakenasen, I. M., Skugor, A., Mydland, L. T., Akesson, C. P., Hellestveit, S. S., Sorby, R., Press, C. M. C. L. & Overland, M. (2019). Candida utilis yeast as a protein source for weaned piglets: Effects on growth performance and digestive function. Livestock Science, 226, 31-39. doi:10.1016/j.livsci.2019.06.003.
Czechowski, C. G., Rosa, A. C. & Cella, P. S. (2017). Effects of sodium butyrate use in pigs performance in the initial stage. Scientific Eletronic Archives, 10(1). doi:10.36560/1012017296.
Denck, F. M., Hilgemberg, J. O. & Lehnen, C. R. (2017). Uso de acidificantes em dietas para leitões em desmame e creche. Archivos de Zootecnia, 66(256), 629-638. doi:10.21071/az.v66i256.2782.
Diao, H., Zhend, P., Yu, B., He, J., Mao, X. B., Yu, J. & Chen, D. W. (2014). Effect of dietary supplementation with benzoic acid on intestinal morphological structure and microflora in weaned piglets. Livestock Science, 167, 249–256. doi:10.1016/j.livsci.2014.05.029.
Dias, L., Dullius, J. L. & Cella, P. S. (2017). Effect of live yeast on performance of piglets. Scientific Eletronic Archives, 10(2), 4. Recuperado de: http://sea.ufr.edu.br/index.php?journal=SEA&page=article&op=view&path%5B%5D=308.
Dumitru, M., Habeanu, M., Sorescu, I., Tabuc, C. & Jurcoane, S. Effects os Bacillus subtilis use as dietary probiotic in weaning piglets. Journal of Biotechonology, 71-72. doi:10.1016/j.jbiotec.2019.05.249.
Ferreira, J. L., Watanabe, P. H., Mendonça, I. B., Nogueira, B. D., Ferreira, A. C. S., Nepomuceno, R. C., Pascoal, L. A. F., Almeida, J. M. S., Guerra, R. R., Trevisan, M. T. S., Silva, I. N. G. & Freitas, E. R. (2020). Calcium anacardate and citric acid as growth promoters for weaned piglets. Livestock Science, 238, 104084. doi:10.1016/j.livsci.2020.104084.
Garcia, G. R., Dogi, C. A., Poloni, V. L., Fochesato, A. S., Leblanc, A. M., Cossalter, A. M., Payros, D., Oswald, I. P. & Cavaglieri, I. R. (2018). Beneficial effects of Saccharomyces cerevisiae RC016 in weaned piglets: in vivo and ex vivo analysis. Beneficial Microbes, 10(1), 33-42. doi:10.3920/BM2018.0023.
Ghorbani, B., Ghorbani, M., Abedi, M. & Tayebi, M. (2016). Effect of Antibiotics Overuse in Animal Food and its Link with Public Health Risk. International Journal of Scientific Research in Science, Engineering and Technology. (2)1, 46-50. Recuperado de: https://www.researchgate.net/profile/Mahin_Ghorbani3/publication/295616575_Effect_of_Antibiotics_Overuse_in_Animal_Food_and_its_Link_with_Public_Health_Risk/links/56cc0e5c08aee3cee542260f.pdf.
Giannenas, I., Papaneophytou, P., Tsalie, E., Pappas, I., Triantafillou, E., Tontis, D. & Kontopidis, G. A. (2014). Dietary Supplementation of Benzoic Acid and Essential Oil Compounds Affects Buffering Capacity of the Feeds, Performance of Turkey Poults and Their Antioxidant Status, pH in the Digestive Tract, Intestinal Microbiota and Morphology. Asian-Australasian Journal of Animal Sciences, 27(2), 225-236. doi:10.5713%2Fajas.2013.13376.
Girard, M. & Bee, G. (2020). Invited review: Tannins as a potential alternative to antibiotics to prevent coliform diarrhea in weaned pigs. Animal, 14(1), 1-13. doi:10.1017/S1751731119002143.
Grecco, H. A. T. (2014). Acidificantes em dietas de leitões desmamados: desempenho, peso de orgãos, pH, morfometria e microbiota intestinal. Dissertação (Mestrado). Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu. p. 65. Recuperado de: https://repositorio.unesp.br/handle/11449/108756.
Gresse, R., Chaucheyras-Durand, F., Fleury, M. A., Van de Wiele, T., Forano, E. & Blanquet-Diot, S. (2017). Gut Microbiota Dysbiosis in Post weaning Piglets: Understanding the Keys to Health. Trends in Microbiology, (25) 10, 851-873. doi:10.1016/j.tim.2017.05.004.
Guzzo, F. B. (2019). Blend de óleos essenciais na dieta de leitões na fase de creche. Trabalho de conclusão de curso, Universidade Federal da Fronteira Sul, Campus Erechim, Curso de Agronomia. p. 26. Recuperado de: https://rd.uffs.edu.br/handle/prefix/3337.
Heo, J. M., Opapeju, F. O., Pluske, J. R., Kim, J. C., Hampson, D. J. & Nyachoti, C. M. (2013). Gastrointestinal health and function in weaned pigs: a review of feeding strategies to control post-weaning diarrhoea without using in-feed antimicrobial compounds. Journal of Animal Physiology and Animal Nutrition, 97(2), 207–237. doi:10.1111/j.1439-0396.2012.01284.x.
Herrera, F. V., Ciro, J. & Parra, J. (2016). La adición de Enterococcus faecium aumenta la respuesta inmune intestinal en cerdos en crecimiento. Archivos de Zootecnia, 65 (251), 389-398. doi:10.21071/az.v65i251.701.
Hu, C., Xing, W., Liu, X., Zhan, X., Li, K., Li, J., Deng, B., Deng, J., Li, Y. & Tan, C. (2019). Effects of dietary supplementation of probiotic Enterococcus faecium on growth performance and gut microbiota in weaned piglets. AMB Express, 9(33), 12. doi:10.1186/s13568-019-0755-z.
Jayaraman, B. & Nyachoti, C. M. (2017). Husbandry practices and gut health outcomes in weaned piglets: A review. Animal Nutrition, 3(1), 205-211. doi:10.1016/j.aninu.2017.06.002.
Jørgensen, J. N., Laguna, J. S., Millán, C., Casabuena, O. & Gracia, M. I. (2016). Effects of a Bacillus-based probiotic and dietary energy content on the performance and nutrient digestibility of wean to finish pigs. Animal Feed Science and Technology, 221, 54-61. doi:10.1016/j.anifeedsci.2016.08.008.
Keerqin, C., Morgan, N. K., Wu, S. B., Swick, R. A. & Choct, M. (2017). Dietary inclusion of arabinoxylo-oligosaccharides in response to broilers challenged with subclinical necrotic enteritis. British Poultry Science, 58(4), 418-424. doi:10.1080/00071668.2017.1327705.
Kheiri, F., Faghani, M. & Landy, N. (2018). Evaluation of thyme and ajwain as antibiotic growth promoter substitutions on growth performance, carcass characteristics and serum biochemistry in Japanese quails (Coturnix japonica). Animal Nutrition, 4(1), 79-83. doi:10.1016/j.aninu.2017.09.002.
La Fata, G., Weber, P. & Mohajeri, M. H. (2017). Probiotics and the gut immune system: Indirect regulation. Probiotics and Antimicrobial Proteins, 10(1), 1-11. doi:10.1007/s12602-017-9322-6.
Lan, R. X., Lee, S. I. & Kim, I. H. (2016). Effects of multistrain probiotics on growth performance, nutrient digestibility, blood profiles, faecal microbial shedding, faecal score and noxious gas emission in weaning pigs. Journal of Animal Physiology and Animal Nutrition, 100(6), 1130–1138. doi:10.1111/jpn.12501.
Le Bourgot, C., Ferret-Bernard, S., Le Normand, L., Savary, G., Menendez-Aparicio, E., Blat, S., Appert-Bossard, E., Respondek, F. & Le Huërou-Luron, I. (2014). Maternal short-chain fructooligosaccharide supplementation influences intestinal immune system maturation in piglets. Plos One, 9(9), e107508. doi:10.1371/journal.pone.0107508.
Le Bourgot, C., Le Normand, L., Fomral, M., Respondek, F., Blat, S., Apper, E., Ferret-Bernard, S. & Le Huërou-Luron, I. (2017). Maternal short-chain fructo-oligosaccharide supplementation increases intestinal cytokine secretion, goblet cell number, butyrate concentration and Lawsonia intracellularis humoral vaccine response in weaned pigs. British Journal of Nutrition, 117(1), 83-92. doi:10.1017/S0007114516004268.
Lee, S., Kim, J., Hancock, J. & Kim, I. (2017). Β-glucan from mulberry leaves and curcuma can improve growth performance and nutrient digestibility in early weaned pigs. Journal of Applied Animal Research, 45(1), 209-214. doi:10.1080/09712119.2016.1141775.
Lei, X. J., Park, J. W., Baek, D. H., Kim, J. K. & Kim, H. (2017). Feeding the blend of organic acids and medium chain fatty acids reduces the diarrhea in piglets orally challenged with enterotoxigenic Escherichia coli K88. Animal Feed Science and Technology, 224, 46-51. doi:10.1016/j.anifeedsci.2016.11.016.
Li, P. F., Piao, X. S., Ru, Y. J., Han, X., Xue, L. F. & Zhang, H. Y. (2012). Effects of adding essential oil to the diet of weaned pigs on performance nutrient utilization, immune response and intestinal health. Journal Animal Science. 25(11), 1617–1626. doi:10.5713%2Fajas.2012.12292.
Li, Y., Fu, X., Ma, X., Geng, S., Jiang, X., Huang, Q., Hu, C. & Han, X. (2018). Intestinal Microbiome-Metabolome Responses to Essential Oils in Piglets. Frontiers in Microbiology, 9. doi:10.3389/fmicb.2018.01988.
Luise, D., Bertocchi, M., Motta, V., Salvarani, C., Bosi, P., Luppi, A., Fanelli, F., Mazzoni, M., Archetti, I., Maiorano, G., Nielsen, B. K. K. & Trevisi, P. (2019). Bacillus sp. probiotic supplementation diminish the Escherichia coli F4ac infection in susceptible weaned pigs by influencing the intestinal immune response, intestinal microbiota and blood metabolomics. Journal of Animal Science and Biotechnology, 10(1), 1-16. doi:10.1186/s40104-019-0380-3.
Machinsky, T. G., Kessler, A. M., Ribeiro, A. M. L., Moraes, M. L., Silva, I. C. M. & Cortés, M. E. M. (2010). Digestibilidade de nutrientes e balanço de Ca e P em suínos recebendo dietas com ácido butírico, fitase e diferentes níveis de cálcio. Ciência Rural, 40(11), 2350-2355. doi:10.1590/S0103-84782010001100016.
Malheiros, F. M. (2018). Quantificação bioeconômica do impacto do bem-estar no desmame e final de creche de suínos. Dissertação (Mestrado em agronegócios), Universidade Federal de Santa Maria (UFSM, RS). p. 71. Recuperado de: https://repositorio.ufsm.br/handle/1/15286.
Mallo, J. J., Balfagon, A., Gracia, M. I., Honrubia, P. & Puyalto, M. (2012). Evaluation of different protections of butyric acid aiming for release in the last part of the gastrointestinal tract of piglets. Journal of Animal Science, 90(4), 227–229. doi:10.2527/jas.53959.
Mao, X., Xiao, X., Chen, D., Yu, B., He, J., Chen, H., Xiao, X., Luo, J. & Tian, G. (2017). Dietary apple pectic oligosaccharide improves gut barrier function of rotavirus-challenged weaned pigs by increasing antioxidant capacity of enterocytes. Oncotarget, 8 (54). 92420-92430. doi:10.18632%2Foncotarget.21367.
Mehdi, Y., Letourneau-Montminy, M. P., Gaucher, M. L., Chorfi, Y., Suresh, G., Rouissi, T., Brar, S. K., Côté, C., Ramirez, A. A. & Godbout, S. (2018). Use of antibiotics in broiler production: Global impacts and alternatives. Animal Nutrition, 4(2), 170-178. doi:10.1016/j.aninu.2018.03.002.
Moser, A. J., Pohl, C. S. & Rajput, M. (2017). Weaning stress and gastrointestinal barrier development: Implications for lifelong gut health in pigs. Animal Nutrition Journal, 3(4), 313-321. doi:10.1016/j.aninu.2017.06.003.
Nagpal, R., Wang, S., AhmadI, S., Hayes, J., Gagliano, J., Subashchandrabose, S., Kitzman, D. W., Becton, T., Read, R. & Yadav, H. (2018). Human-origin probiotic cocktail increases short-chain fatty acid production via modulation of mice and human gut microbiome. Scientific Reports, 8(1), 1–15. doi:10.1038/s41598-018-30114-4.
Noschang, J. P., De Moraes, R. E., Carpinelli, A. N., Schmidt, I. P., De Oliveira, V. D., Silveira, R. F. & Silveira, I. D. B. (2017). Promotores de crescimento (antibióticos) na alimentação de suínos – Revisão de Literatura. Revista Electrônica de Veterinária, 18(11), 1-13. Recuperado de: https://www.redalyc.org/pdf/636/63653574003.pdf.
Oh, H. J., Kim, I. H., Song, M. H., Kwak, W. G., Yun, W., Lee, J. H., Lee, C. H., Oh, S. Y., Liu, S., An, J. S., Kim, H. & Cho, J. H. (2019). Effects of microencapsulated complex of organic acids and essential oils on growth performance, nutrient retention, blood profiles, fecal microflora and lean meat percentage in weaning to finishing pigs. Canadian Journal of Animal Science, 99(1), 41-49. doi:10.1139/cjas-2018-0006.
Ollé, M. A., Groff, P. M., Ruas, M. S., Ollé, F. A., Fluck, A. C., Silveira, R. F. & Alfaya, H. (2017). Uso de antibióticos na alimentação de suínos. Revista Electrónica de Veterinaria, 18(10) 1-18. Recuperado de: https://www.redalyc.org/pdf/636/63653470001.pdf.
Patil, A. K., Kumar, S., Verma, A. K. & Baghel, R. P. S. (2015). Probiotics as Feed Additives in Weaned Pigs: A review. Livestock Research International, 3(2), 31-39. Recuperado de: http://www.jakraya.com/journal/pdf/8-lriArticle_1.pdf.
Pereira, A. S., Shitsuka, D. M., Parreira, F. J. & Shitsuka, R. (2018). Metodologia da pesquisa científica. [e-book]. Santa Maria. Ed. UAB/NTE/UFSM. Recuperado de: http://repositorio.ufsm.br/handle/1/15824.
Pluske, J. R., Turpin, D. L. & Kim, J-C. (2018). Gastrointestinal tract (gut) health in the young pig. Animal Nutrition, 4(2), 187-196. doi:10.1016/j.aninu.2017.12.004.
Purchiaroni, F., Tortora, A., Gabrielli, M., Bertucci, F., Gigante, G., Ianiro, G., Ojetti, V., Scarpellini, E. & Gasbarrini, A. (2013). The role of intestinal microbiota and the immune system. European Review for Medical and Pharmacological Sciences, 17(3), 323-333. Recuperado de: https://europepmc.org/article/med/23426535.
Puvača, N., Stanaćev, V., Glamočić, D., Lević, J., Perić, L., Stanaćev, V. & Milić, D. (2013). Beneficial effects of phytoadditives in broiler nutrition. World’s Poultry Science Journal, 69(1), 27-34. doi:10.1017/S0043933913000032.
Qin, L., Ji, W., Wang, J., Li, B., Hu, J. & Wu, X. (2019). Effects of dietary supplementation with yeast glycoprotein on growth performance, intestinal mucosal morphology, immune response and colonic microbiota in weaned piglets. Food & Function, (5), 2359-2371. doi:10.1039/C8FO02327A.
Ramos, D. R. A. (2020). Uso de combinações de prebióticos em dietas de leitões recém-desmamados. Dissertação (Mestrado em Medicina Veterinária), Programa de Pós-Graduação em Zootecnia, Universidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária e Zootecnia, Botucatu. p. 55. Recuperado de: https://repositorio.unesp.br/handle/11449/191787.
Raut, J. S. & Karuppayil, S. M. (2014). A status review on the medicinal properties of essential oils. Industrial Crops and Products, 62(1), 250-264. doi:10.1016/j.indcrop.2014.05.055.
Rhouma, M., Fairbrother, J. M., Beaudry, F. & Letellier, A. (2017). Post weaning diarrhea in pigs: risk factors and non-colistin-based control strategies. Acta Veterinaria Scandinavica, 59(1), 1-19. doi:10.1186/s13028-017-0299-7.
Rodrigues, L. M., Neto, T. O. de A. L., Garbossa, C. A. P., Martins, C. C. S., Garcez, D., Alves, L. K. S., Abreu, M. L. T.; Ferreira, R. A. & Cantarelli, V. S. (2020). Benzoic Acid Combined with Essential Oils Can Be an Alternative to the Use of Antibiotic Growth Promoters for Piglets Challenged with E. coli F4. Animals, 10(11), 1978. doi:10.3390/ani10111978.
San Andres, J. V., Mastromano, G. A., Li, Y., Tran, H., Bundy, J. W., Miller, P. S. & Burkey, T. E. (2019). The effects of prebiotics on growth performance and in vitro immune biomarkers in weaned pigs. Translational Animal Science, 3(4), 1315-1325. doi:10.1093/tas/txz129.
Sanders, M. E., Benson, A., Lebeer, S., Merenstein, D. J. & Klaenhammer, T. R. (2018). Shared mechanisms among probiotic taxa: Implications for general probiotic claims. Current Opinion in Biotechnology, 49, 207–216. doi:10.1016/j.copbio.2017.09.007.
Sant’ana, D. S., Magalhães, M. L., Magalhães, C. F., Antunes, R. C., Oliveira, M. T., Freitas, P. F. A. & Mundim, A. V. (2017). Efeitos da adição de leveduras (Saccharomyces cerevisae) na ração de leitões desmamados. Investigação, 16(8), 16-21. doi:10.26843/investigacao.v16i8.1744.
Santos, A. V., Fialho, E. T., Zangerônimo, M. G., Cantarelli, V. S., Teofilo, T. S. & Molino, J. P. (2016). Aditivos Antibióticos, Probióticos e Prebióticos em rações para leitões desmamados precocemente. Ciência Animal Brasileira, 17(1), 1-10. Recuperado de: https://www.revistas.ufg.br/vet/article/view/14934.
Shang, W., Si, W., Zhou, Z., Li, Y., Strappe, P. & Blanchard, C. (2017). Characterization of fecal fat composition and gut derived fecal microbiota in high-fat diet fed rats following intervention with chito-oligosaccharide and resistant starch complexes. Food of Function, 8(12), 4374-4383. doi:10.1039/C7FO01244F.
Silva Júnior, C. D., Martins, C. C. S., Dias, F. T. F., Sitanaka, N. Y., Ferracioli, L. B., Moraes, J. E., Pizzolante, C. C., Budiño, F. E. L., Pereira, R., Tizioto, P., Paula, V. R. C., Coutinho, L. L. & Ruiz, U. S. (2020). The use of an alternative feed additive, containing benzoic acid, thymol, eugenol and piperine, improved growth performance, nutrient and energy digestibility and gut health in weaned piglets. Journal of Animal Science, 98(5), 1-35, doi:10.1093/jas/skaa119.
Silva, G. A., Rorig, A., Schimidt, J. M. & Guirro, E. C. B. P. (2014). Impacto do desmame no comportamento e bem-estar de leitões: revisão de literatura. Veterinária em Foco, 12(1), 1-17. Recuperado de: http://www.periodicos.ulbra.br/index.php/veterinaria/article/view/1507/1487.
Silva, S. Z., Thomaz, M. C., Watanabe, P. H., Robles-Huaynate R. A., Ruiz, U. S., Pascoal, L. A., Santos V. M. & Masson, G. C. I. H. (2012). Mananoligossacarídeo em dietas para leitões desmamados. Brazilian Journal of Veterinary Research Animal Science, 49(2), 102-110. Recuperado de: http://www.revistas.usp.br/bjvras/article/view/40265.
Silva, T. R. G., Martins, T. D. D., Silva, J. H. V., Silva, L. P. G., Pascoal, L. A. F., Oliveira, E. R. A. & Brito, M. S. (2012). Inclusão de óleos essenciais como elementos fitoterápicos na dieta de suínos. Revista Brasileira de Saúde e Produção Animal, 23(1), 11. doi:10.1590/S1519-99402012000100016.
Sinhorin, A. L., Costa, R. J., Previato Do Amaral, P. F. G., Beltrami, J. M., Sá, T. C., Caetano, I. C. S. & Ottumi, L. K. (2017). Óleo essencial na dieta de leitões na fase de creche. Arquivos de Ciências Veterinárias e Zoologia da UNIPAR, 20(3), 147-151. Recuperado de: https://www.revistas.unipar.br/index.php/veterinaria/article/view/6691.
Slavin, J. (2013). Fiber and prebiotics: mechanisms and health benefits. Nutrients, 5(4), 1417-1435. doi:10.3390/nu5041417.
Su, G., Zhou, X., Wang, Y., Chen, D., Chen, G., Li, Y. & He, J. (2018). Effects of plant essential oil supplementation on growth performance, imune function and antioxidant activities in weaned pigs. Lipids in Health and Disease, 17, 139. doi:10.1186/s12944-018-0788-3.
Suzuki, O. H., Flemming, J. S. & Silva, M. E. T. (2008). Uso de óleos essenciais na alimentação de leitões. Revista Acadêmica Ciência Animal, 6(4), 519-526. Recuperado de: https://periodicos.pucpr.br/index.php/cienciaanimal/article/view/11648.
Taciak, M., Barszcz, M., Święch, E., Tuśnio, A. & Bachanek, I. (2017). Interactive effects of protein and carbohydrates on production of microbial metabolites in the large intestine of growing pigs. Archives of Animal Nutrtion, 71(3), 192-209. doi:10.1080/1745039X.2017.1291202.
Tian, Q. & Piao, X. (2019). Essential Oil Blend Decrease Diarrhea Prevalence by Improving Antioxidative Capability for Weaned Pigs. Animals, 9(10), 847. doi:10.3390/ani9100847.
Tongnuanchan, P. & Benjakul, S. (2014). Essential Oils: Extraction, bioactivities, and their uses for food preservation. Journal of Food Science, 79(7), 1231-1249. doi:10.1111/1750-3841.12492.
Upadhaya, S. A., Lee, K. Y. & Kim, I. H. (2014). Influence of protected organic acid blends and diets with different nutrient densities on growth performance, nutrient digestibility and fecal noxious gas emission in growing pigs. Veterinární Medicína, 59(10), 491-497. Recuperado de: http://vri.cz/docs/vetmed/59-10-491.pdf.
Valeriano, V. D. V., Balolong, M. P. & Kang, D.-K. (2017). Probiotic Roles of Lactobacillus spp. in Swine: Insigths from Gut Microbiota. Journal of Applied Microbiology. 122(3), 554-567. doi:10.1111/jam.13364.
Ventola, C. L. (2015). The antibiotic resistance crisis: part 1: causes and threats. Pharmacy and Therapeutics, 40(4): 277–283. Recuperado de: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378521/.
Vieites, F. M., Souza, C. S., Castro, A. C. S., Júnior, A. M. M., Ferreira, M. H., Ferreira, S. E., Varelha, G. O. M. & Oliveira, G. P. (2020). Aditivos zootécnicos na alimentação de suínos – Revisão de Literatura. Brazilian Journal of Development, 6(7), 45880-45895. doi:10.34117/bjdv6n7-276.
Wang, X., Tian, Z., Azad, M. A. K., Zhang, W., Blachier, F., Wang, Z. & Kong, X. (2020). Dietary supplementation with Bacillus mixture modifies the intestinal ecosystem of weaned piglets in an overall beneficial way. Journal of Applied Microbiology, 14. doi:10.1111/jam.14782.
Wang, Y., Kuang, Y., Zhang, Y., Song, Y., Zhang, X., Lin, Y., Che, L., Xu, S., Wu, D., Xue, B. & Fang, Z. (2016). Rearing conditions affected responses of weaned pigs to organic acids showing a positive effect on digestibility, microflora and immunity. Animal Science Journal, 87(10), 1267–1280. doi:10.1111/asj.12544.
Yang, Y., Lee, K. Y., Kim, I. H. (2019). Effects of dietary protected organic acids on growth performance, nutrient digestibility, fecal microflora, diarrhea score and fecal gas emission in weanling pigs. Canadian Journal of Animal Science, 99(3), 514-520. doi:10.1139/cjas-2018-0159.
Zeng, Z. K., Zhang, S., Wang, H. L. & Piao, X. S. (2015). Essential oil and aromatic plants as feed additives in non-ruminant nutrition: a review. Journal of Animal Science, Biotechnology, 6(1), 7. doi:10.1186/s40104-015-0004-5.
Zenhom, M., Hyder, A., De Vrese, M., Heller, K. J., Roeder, T. & Schrezenmeier, J. (2011). Prebiotic oligosaccharides reduce pro inflammatory cytokines in intestinal caco-2 cells via activation of PPARγ and peptidoglycan recognition protein 3. Journal of Nutrition, 141(5), 971-977. doi:10.3945/jn.110.136176.
Zhai, H., Luo, Y., Ren, W., Schyns, G. & Guggenbuhl, P. (2020). The effects of benzoic acid and essential oils on growth performance, nutrient digestibility, and colonic microbiota in nursery pigs. Animal Feed Science and Technology, 262, 10. doi:10.1016/j.anifeedsci.2020.114426.
Zhai, H., Ren, W., Wang, S., Wu, J. & Guggenbuhl, P. (2017). Growth performances of nursery and grower-finisher pigs fed diets supplemented with benzoic acid. Animal Nutrition, 3(3), 232–235. doi:10.1016/j.aninu.2017.05.001.
Zhang, S., Yoo, D. H., Ao, X. & Kim, I. H. (2020). Effects of dietary probiotic, liquid feed and nutritional concetration on the growth performance, nutrient dihestibility and fecalscore of weaning piglets. Asian-Australasian Journal of Animal Sciences, 33(10), 1617-1623. doi:10.5713%2Fajas.19.0473.
Zhang, W-X., Zhang, Y., Zhang, X-W., Deng, Z-X., Liu, J-X., He, M-L. & Wang, H-F. (2020). Effects of Dietary Supplementation with Combination of Tributyrin and Essential Oil on Gut Health and Microbiota of Weaned Piglets. Animals, 10(2), 180. doi:10.3390/ani10020180.
Zhu, C., Wang, L., Wei, S-Y., Chen, Z., Ma, X-Y., Zheng, C-T. & Jiang, Z-Y. (2017). Effect of yeast Saccharomyces cerevisiae supplementation on serum antioxidant capacity, mucosal sIgA secretions and gut microbial populations in weaned piglets. Journal of Integrative Agriculture, 16(9), 2020-2037. doi:10.1016/S2095-3119(16)61581-2.
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