Cryptococcosis: a consequence of Cryptococcus neoformans infection in AIDS patients in Brazil

Authors

DOI:

https://doi.org/10.33448/rsd-v10i15.22591

Keywords:

Cryptococcus neoformans; Diagnosis; Immunodepressions; Opportunistic infection; Treatment.

Abstract

This research aims to understand the consequences of infection by Cryptococcus neoformans in patients with AIDS in Brazil, as well as to understand the development of C. neoformans in people with AIDS and highlight the diagnosis, symptoms and treatment of cryptococcosis. The present study consists of integrative bibliographic research with the main sources: articles, theses scientific journals electronic magazines. The digital platform seeks form: Scientific Electronic Library Online (SCIELO), Latin American and Caribbean Literature on Health Sciences (LILACS), Virtual Health Library (VHL) and Google Scholar. The inclusion criteria published within the estimated period are studies published between 2012 and 2021 that appear in the Portuguese english languages. Exclusion criteria were articles that do not address the conniving ideas of the work, repeated articles or with insufficient data and that does not fit the objective of the research. It was concluded that the opportunistic infection of C. neoformans presented result in the obtained of HIV-infected patients. In these cases, treatment in HIV-infected patients with cryptococcosis initially occurs, deporting antiretroviral therapy within 5 weeks, after antifungal therapy is initiated. However, in the course it is necessary to be careful with the control of intracranial pressure for cryptococcal meningitis and the supply of ARVs to restore immune function are necessary for the treatment to be successful. Finally, it is noteworthy that it is necessary to invest in health so that the early diagnosis of the fungus C. neoformans is made quickly and helpfully for this public, since this fungus is characterized as opportunistic.

References

Almeida-Silva, F. et al. (2016) Multiple opportunistic fungal infections in an individual with severe HIV disease: a case report. Revista iberoamericana de micologia, 33(2), 118-121.

Araújo Júnior, E. C. A., Táparo, C. V., Uchida, C. Y., & Marinho, M. (2015). Cryptococcus: isolamento ambiental e caracterização bioquímica. Arquivo Brasileiro de Medicina veterinária e zootecnia, 67(4), 1003-1008.

Brito-Santos F., Barbosa G. G., Trilles L., Nishikawa M. M., Bodo Wanke B., Meyer W., Carvalho-Costa F. A., & Lazéra M. S. (2015) Environmental Isolation of Cryptococcus gattii VGII from Indoor Dust from Typical Woen Houses in the Deep Amazonas of the Rio Negro Basin. PLoS ONE. 10(2),0115866.

Carrijo, A. V., Carrijo, B. V., Machado, L. N., Almeida, R. J de, & Oliveira, P. P. C. de. (2021). Análise clínico-epidemiológica de criptococose em indivíduos com hiv: uma revisão sistemática/clinical-epidemiological analysis of cryptococosis and hiv coinfection. Brazilian Applied Science Review, 5(2), 802-817.

Chastain, D. B., Henao-martínez, A. F., & Franco-paredes, C. (2017) Opportunistic invasive mycoses in Aids: cryptococcosis, histoplasmosis, coccidiodomycosis, and talaromycosis. Current infectious disease reports, 19(10), 36.

Derbie, A. et al. (2018) Magnitude of Cryptococcal Antigenemia among HIV Infected Patients at a Referral Hospital, Northwest Ethiopia. Ethiopian Journal of Health Sciences, 28(4).

Diniz, A. M. M., Feio, D. C. A., Silva, A. S. N., Burbano. R. R., & Lima, P. D. L de. (2019). Epidemiological and TNFa polymorphism evaluation in patients with cryptococcal meningitis treated at a referral hospital in North Brazil. Rev. Soc. Bras. Med. Trop. (52).

Ferreira, M. D. F. (2016). Prevalência de antigenemia criptocócica em pacientes HIV positivos com imunossupressão avançada no Instituto Nacional de Infectologia Evandro Chagas (Doctoral dissertation).

Firacative C., Lizarazo J., Illnait-ZaragozÍ M. T., & Castañeda E. (2018) The status of cryptococcosis in Latin America. Mem. Inst. Oswaldo Cruz. 113(7), e170554.

Gbangba-Ngai E., Fikouma V., Mossoro-Kpinde C. D., Tekpa G., Ouavene J. O., Yangba Mongba D. S. A., & Mbelesso P. (2014) La cryptococcose neuroméningée au cours de l’infection à VIH à Bangui, à l’ère du traitement antirretroviral. Bull. Soc. Pathol. Exot. 107, 106-109.

Henao-Martínez A. F., & Beckham J. D. (2015) Cryptococcosis in solid organ transplant recipientes. Curr Opin Infect Dis. 28(4),

HAgen F, et al. (2017) Importance of Resolving Fungal Nomenclature: the Case of Multiple Pathogenic Species in the Cryptococcus Genus. MSphere.2(4): e 00238-17.

Kwon-Chung, K. J., et al. (2017) The Case for Adopting the “Species Complex” Nomenclature for the Etiologic Agents of Cryptococcosis. mSphere. 2(1),27e00357-16.

Luo, F. L. et al. (2015) Clinical study of 23 pediatric patients with cryptococcosis. Eur Rev Med Pharmacol Sci, 19(20), 38013810.

Molloy, S. F. (2018) et al. Antifungal combinations for treatment of cryptococcal meningitis in Africa. New England Journal of medicine. 378(11), 1004-1017.

Moraes, G. Y. B. de, et al (2018) Invencioni, Fisiopatologia Da Criptococose Em Pacientes Com Hiv/Aids E O Papel Do Biomédico Physiopathology Of Cryptococosis In Patients With Hiv / Aids And The Role Of Biomedical. Ed – nº 10.

Oliveira, L. V. V. D. (2020). Criptococcose: causas, tratamento e epidemiologia.

Oliveira, L. D. Q. (2017). Influência dos óleos essenciais de cinnamomum cassia e cymbopogon flexuosus sobre a suscetibilidade e fatores de virulência em leveduras do complexo Cryptococcus neoformans. (Dissertação de Mestrado). Universidade Federal de Goiás, Goiânia.

Organização Pan-Americana da Saúde (OPAS). Acesso a medicamentos para HIV foi severamente impactado pela COVID-19. OPAS/MS, 2020 https://www.paho.org/pt/noticias/6-7-2020-oms-acesso-medicamentos-para-hiv-foi-severamente-impactado-pela-covid-19.

Organização Pan-Americana da Saúde (OPAS). Doenças Transmissíveis & Análise de Situação de Saúde: OPAS/MS, 2017. https://www.paho.org/bra/index.php?option=com_content&view=article&id=5666:folha-informativa-hiv-aids&Itemid=812.

Prodanov., C. C., & De Freitas., E. C, (2013). Metodologia do Trabalho Científico: Métodos e Técnicas da Pesquisa e do Trabalho Acadêmico.

Queiroz, E. P., Santana, J. C., Barbosa, L. M. S., & Maia, C. S. (2018). Relação entre a criptococose e indivíduos portadores do HIV. American Journal of HIV/AIDS Research.

Silva., L. B. (2018) Criptococose em um centro de referência em HIV-AIDS no Extremo Sul do Brasil,p 77.

Souza, R. G. de, & Souza, C. M. de. (2018). Incidência de Cryptococcus neoformansem fezes de pombos (Columba Livia) na área central da cidade de Porto Velho, RO. Revista Saber Cientifico, 7(1), 13-22.

Srikanta D., Santiago‐ Tirado F. H., & Doering, T. L. (2014) Cryptococcus neoformans: historical curiosity to modern pathogen Yeast. 31(2), 47-60.

Sharma, S. R. et al. (2017) Neurological manifestations of HIV-AIDS at a tertiary care institute in North Eastern India. Neurology India. 65, (1) 64. DOI:10.34115/basrv5n2-014

Vidal, J. E. et al. (2018) Performance of cryptococcal antigen lateral flow assay in serum, cerebrospinal fluid, whole blood, and urine in HIV-infected patients with culture-proven cryptococcal meningitis admitted at a Brazilian referral center. Revista do Instituto de Medicina Tropical de São Paulo. 5(2),60.

Published

16/11/2021

How to Cite

SANTOS, E. F. dos .; FIGUEIREDO, E. F. G. . Cryptococcosis: a consequence of Cryptococcus neoformans infection in AIDS patients in Brazil . Research, Society and Development, [S. l.], v. 10, n. 15, p. e150101522591, 2021. DOI: 10.33448/rsd-v10i15.22591. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/22591. Acesso em: 28 apr. 2024.

Issue

Section

Health Sciences