Cymbopogon sp. from ethnobotany to antimicrobial: an integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i9.31587

Keywords:

Plants, Medicinal; Phytotherapy; Ethnopharmacology; Poaceae; Lemongrass; Microbiology.

Abstract

Considering the broad potential of the genus Cymbopogon, here we present a systematic literature survey on it’s antimicrobial potential. This is a review, articles from the Scielo and PubMed platforms. The articles surveyed were published between 2015 and 2020, with the theme of microbiology, including ethnobotanical studies, literature reviews, in vitro, in vivo, reports of clinical trials. Works outside the selected period, duplicate articles, and those only reporting infections of plants by the microorganism were excluded. 98 studies were selected, 74% found in PubMed and 26% in Scielo. Of this total, 21% were ethnobotanical/ethnopharmacology or literature reviews, most of them reporting the use of infusions of the species C. citratus (DC.) Stapf. Moreover, in 57% of the studies, survey respondents did not report antimicrobial use. In relation to 79% of the experimental studies, it was observed that 77% reported total inhibition of microbial growth, 3% indicated moderate growth inhibition, 4% low growth inhibition and 5% reported no inhibition. Among the microbial species analyzed were Escherichia coli, Pseudomonas aeruginosa, Borrelia burgdorferi, Candida albicans, Salmonella enterica and Saccharomyces cerevisiae. In addition, 5% of the articles reported antiviral activity, 5% parasitic control, 1% preventive action against contamination by mesophilic microorganisms. Although the population is not aware of the antimicrobial activity of Cymbopogon sp., studies have demonstrated its antimicrobial potential, thus the extracts of this genus can be an alternative for use in folk medicine as well as a source of new drugs with antimicrobial action.

Author Biography

Guilherme Mendes Prado, Universidade Federal do Ceará

Farmacêutico, formado no Centro Universitário INTA (UNINTA), atuou como representante de turma 2015.1 a 2019.2 perante à instituição. Ex-membro do Grupo de Estudo das Plantas Medicinais Serra da Meruoca (GEPSEM), ex-bolsista de iniciação científica pela Funcap na EMBRAPA Ovinos e Caprinos, na área de sanidade animal, mais especificamente desenvolvendo atividades no laboratório de virologia, ex-membro da Liga de Plantas Medicinais do UNINTA (LAPLAM) e ex-estagiário no laboratório de Análises Clínicas (Laboratório Clínico de Sobral) atuando nas áreas de Microbiologia, Imunologia, Citologia, Hormônios e Núcleo de Controle de Qualidade. Atualmente mestrando pelo programa de pós-graduação em Ciências da Saúde pela Universidade Federal do Ceará (UFC).

References

Adukwu, E. C., Bowles, M., Edwards-Jones, V., & Bone, H. (2016). Antimicrobial activity, cytotoxicity and chemical analysis of lemongrass essential oil (Cymbopogon flexuosus) and pure citral. Applied microbiology and biotechnology, 100(22), 9619-9627. https://doi.org/10.1007/s00253-016-7807-y

Ahmad, A., & Viljoen, A. (2015). The in vitro antimicrobial activity of Cymbopogon essential oil (lemon grass) and its interaction with silver ions. Phytomedicine, 22(6), 657-665. https://doi.org/10.1016/j.phymed.2015.04.002

Almeida, L. D. F. D. D., Paula, J. F. D., Almeida, R. V. D. D., Williams, D. W., Hebling, J., & Cavalcanti, Y. W. (2016). Efficacy of citronella and cinnamon essential oils on Candida albicans biofilms. Acta Odontologica Scandinavica, 74(5), 393-398. https://doi.org/10.3109/00016357.2016.1166261

Almeida, K. B., Araujo, J. L., Cavalcanti, J. F., Romanos, M. T. V., Mourão, S. C., Amaral, A. C. F., & Falcão, D. Q. (2018). In vitro release and anti-herpetic activity of Cymbopogon citratus volatile oil-loaded nanogel. Revista Brasileira de Farmacognosia, 28(4), 495-502. http://dx.doi.org/10.1016/j.bjp.2018.05.007

Amoateng, P., Quansah, E., Karikari, T. K., Asase, A., Osei-Safo, D., Kukuia, K. K. E., ... & Nyarko, A. K. (2018). Medicinal plants used in the treatment of mental and neurological disorders in Ghana. Evidence-Based Complementary and Alternative Medicine, 2018. https://doi.org/10.1155/2018/8590381

Avoseh, O., Oyedeji, O., Rungqu, P., Nkeh-Chungag, B., & Oyedeji, A. (2015). Cymbopogon species; ethnopharmacology, phytochemistry and the pharmacological importance. Molecules, 20(5), 7438-7453. https://doi.org/10.3390/molecules20057438

Baana, K., Angwech, H., & Malinga, G. M. (2018). Ethnobotanical survey of plants used as repellents against housefly, Musca domestica L.(Diptera: Muscidae) in Budondo Subcounty, Jinja District, Uganda. Journal of ethnobiology and ethnomedicine, 14(1), 1-8. https://doi.org/10.1186/s13002-018-0235-6

Balouiri, M., Sadiki, M., & Ibnsouda, S. K. (2016). Methods for in vitro evaluating antimicrobial activity: A review. Journal of pharmaceutical analysis, 6(2), 71-79. https://doi.org/10.1016/j.jpha.2015.11.005

Bansod, S. D., Bawaskar, M. S., Gade, A. K., & Rai, M. K. (2015). Development of shampoo, soap and ointment formulated by green synthesised silver nanoparticles functionalised with antimicrobial plants oils in veterinary dermatology: treatment and prevention strategies. IET nanobiotechnology, 9(4), 165-171. https://doi.org/10.1049/iet-nbt.2014.0042

Bermúdez-Vásquez, M. J., Granados-Chinchilla, F., & Molina, A. (2019). Composición química y actividad antimicrobiana del aceite esencial de Psidium guajava y Cymbopogon citratus. Agronomía mesoamericana, 30(1), 147-163. http://dx.doi.org/10.15517/am.v30i1.33758

Bieski, I. G. C., Leonti, M., Arnason, J. T., Ferrier, J., Rapinski, M., Violante, I. M. P., & de Oliveira Martins, D. T. (2015). Ethnobotanical study of medicinal plants by population of valley of Juruena region, legal amazon, Mato Grosso, Brazil. Journal of ethnopharmacology, 173, 383-423. https://doi.org/10.1016/j.jep.2015.07.025

Boeira, C. P., Piovesan, N., Soquetta, M. B., Flores, D. C. B., Lucas, B. N., Rosa, C. S. D., & Terra, N. N. (2018). Extraction of bioactive compounds of lemongrass, antioxidant activity and evaluation of antimicrobial activity in fresh chicken sausage. Ciência Rural, 48(11). https://doi.org/10.1590/0103-8478cr20180477

BRASIL. Ministério da Saúde. Portaria nº 702, de 21 de março de 2018. Altera a Portaria de Consolidação nº 2/GM/MS, de 28 de setembro de 2017, para incluir novas práticas na Política Nacional de Práticas Integrativas e Complementares-PNPIC. Diário Oficial da União, 2018.

BRASIL. Ministério da Saúde. Secretaria de Ciência, Tecnologia e Insumos Estratégicos, Departamento de Assistência Farmacêutica. Política e Programa Nacional de Plantas Medicinais e Fitoterápicos. Brasília: Ministério da Saúde, 2016.

Caetano, N. L. B., Ferreira, T. F., Reis, M. R. O., Neo, G. G. A., & Carvalho, A. A. (2015). Plantas medicinais utilizadas pela população do município de Lagarto-SE, Brasil–ênfase em pacientes oncológicos. Revista Brasileira de Plantas Medicinais, 17(4), 748-756. https://doi.org/10.1590/1983-084X/14_056

Chaftar, N., Girardot, M., Labanowski, J., Ghrairi, T., Hani, K., Frere, J., & Imbert, C. (2015). Comparative evaluation of the antimicrobial activity of 19 essential oils. In Advances in microbiology, infectious diseases and public health (pp. 1-15). Springer, Cham. https://doi.org/10.1007/5584_2015_5011

Cherian, T., Ali, K., Saquib, Q., Faisal, M., Wahab, R., & Musarrat, J. (2020). Cymbopogon citratus functionalized green synthesis of CuO-nanoparticles: Novel prospects as antibacterial and antibiofilm agents. Biomolecules, 10(2), 169. https://doi.org/10.3390/biom10020169

Chiamenti, L., Silva, F. P. D., Schallemberger, K., Demoliner, M., Rigotto, C., & Fleck, J. D. (2019). Cytotoxicity and antiviral activity evaluation of Cymbopogon spp hydroethanolic extracts. Brazilian Journal of Pharmaceutical Sciences, 55. http://dx.doi.org/10.1590/s2175-97902019000118063

Chukwuocha, U. M., Fernández-Rivera, O., & Legorreta-Herrera, M. (2016). Exploring the antimalarial potential of whole Cymbopogon citratus plant therapy. Journal of ethnopharmacology, 193, 517-523. https://doi.org/10.1016/j.jep.2016.09.056

Clement, Y. N., Baksh-Comeau, Y. S., & Seaforth, C. E. (2015). An ethnobotanical survey of medicinal plants in Trinidad. Journal of ethnobiology and ethnomedicine, 11(1), 1-28. https://doi.org/10.1186/s13002-015-0052-0

Córdoba, S., Vivot, W., Szusz, W., & Albo, G. (2019). Antifungal activity of essential oils against Candida species isolated from clinical Samples. Mycopathologia, 184(5), 615-623. https://doi.org/10.1007/s11046-019-00364-5

Costa, K. A. D., Moura, R., & Millezi, A. F. (2019). Antimicrobial and antibiofilm activity of Cymbopogon flexuosus essential oil microemulsions. Revista Ceres, 66(5), 372-379. https://doi.org/10.1590/0034-737x201966050006

Cunha, B. G., Duque, C., Caiaffa, K. S., Massunari, L., Catanoze, I. A., Dos Santos, D. M., & Guiotti, A. M. (2020). Cytotoxicity and antimicrobial effects of citronella oil (Cymbopogon nardus) and commercial mouthwashes on S. aureus and C. albicans biofilms in prosthetic materials. Archives of oral biology, 109, 104577. https://doi.org/10.1016/j.archoralbio.2019.104577

Da Silva Gündel, S., de Souza, M. E., Quatrin, P. M., Klein, B., Wagner, R., Gündel, A., & Ourique, A. F. (2018). Nanoemulsions containing Cymbopogon flexuosus essential oil: Development, characterization, stability study and evaluation of antimicrobial and antibiofilm activities. Microbial pathogenesis, 118, 268-276. https://doi.org/10.1016/j.micpath.2018.03.043

De Castro, M. R., & Figueiredo, F. F. (2020). 240. Estudos e pesquisas sobre o uso de plantas medicinais e fitoterápicas no Brasil: caminhos e desafios. Ar@ cne, 24. https://doi.org/10.1344/ara2020.240.30986

De Santana, B. F., Voeks, R. A., & Funch, L. S. (2016). Ethnomedicinal survey of a maroon community in Brazil's Atlantic tropical forest. Journal of ethnopharmacology, 181, 37-49. https://doi.org/10.1016/j.jep.2016.01.014

De Silva, B. C. J., Jung, W. G., Hossain, S., Wimalasena, S. H. M. P., Pathirana, H. N. K. S., & Heo, G. J. (2017). Antimicrobial property of lemongrass (Cymbopogon citratus) oil against pathogenic bacteria isolated from pet turtles. Laboratory animal research, 33(2), 84-91. https://doi.org/10.5625/lar.2017.33.2.84

De Toledo, L. G., Ramos, M. A. D. S., Spósito, L., Castilho, E. M., Pavan, F. R., Lopes, É. D. O., & De Almeida, M. T. G. (2016). Essential oil of Cymbopogon nardus (L.) Rendle: A strategy to combat fungal infections caused by Candida species. International Journal of Molecular Sciences, 17(8), 1252. https://doi.org/10.3390/ijms17081252

Dias, N., Dias, M. C., Cavaleiro, C., Sousa, M. C., Lima, N., & Machado, M. (2017). Oxygenated monoterpenes-rich volatile oils as potential antifungal agents for dermatophytes. Natural product research, 31(4), 460-464. https://doi.org/10.1080/14786419.2016.1195379

Djemam, N., Lassed, S., Gül, F., Altun, M., Monteiro, M., Menezes-Pinto, D., & Morato, M. (2020). Characterization of ethyl acetate and n-butanol extracts of Cymbopogon schoenanthus and Helianthemum lippii and their effect on the smooth muscle of the rat distal colon. Journal of ethnopharmacology, 252, 112613. https://doi.org/10.1016/j.jep.2020.112613

Donato, R., Sacco, C., Pini, G., & Bilia, A. R. (2020). Antifungal activity of different essential oils against Malassezia pathogenic species. Journal of ethnopharmacology, 249, 112376. https://doi.org/10.1016/j.jep.2019.112376

Ekpenyong, C. E., Akpan, E., & Nyoh, A. (2015). Ethnopharmacology, phytochemistry, and biological activities of Cymbopogon citratus (DC.) Stapf extracts. Chinese journal of natural medicines, 13(5), 321-337. https://doi.org/10.1016/S1875-5364(15)30023-6

FERREIRA, S. K. S., CUNHA, I. P., MENEGHIM, M. C., & DE CHECCHI, M. H. R. (2020). Política nacional de práticas integrativas e complementares no sistema único de saúde. Revista Faipe, 10(1), 21-39. http://www.revistafaipe.com.br/index.php/RFAIPE/article/view/144

Gholizadeh, P., Eslami, H., Yousefi, M., Asgharzadeh, M., Aghazadeh, M., & Kafil, H. S. (2016). Role of oral microbiome on oral cancers, a review. Biomedicine & Pharmacotherapy, 84, 552-558. https://doi.org/10.1016/j.biopha.2016.09.082

Goulart, L., de Oliveira, F. R. A., de Araújo, R. A. F., da Silva Santos, D. A., de Mattos, M., & Olinda, R. A. (2020). Uso de plantas medicinais no município de Rondonópolis, Mato Grosso, Brasil. Revista Enfermagem Atual In Derme, 92(30). https://doi.org/10.31011/reaid-2020-v.92-n.30-art.691

Gross, A. V., Stolz, E. D., Müller, L. G., Rates, S. M. K., & Ritter, M. R. (2019). Medicinal plants for the" nerves": a review of ethnobotanical studies carried out in South Brazil. Acta Botanica Brasilica, 33(2), 269-282. https://doi.org/10.1590/0102-33062018abb0386

Intriago, L. F. Z., Allauca, M. P. B., Rodríguez, N. J. M., & Romero, E. J. (2015). Estudio etnobotánico de plantas medicinales utilizadas por los habitantes del área rural de la Parroquia San Carlos, Quevedo, Ecuador. Universidad y Salud, 17(1), 97-111. https://revistas.udenar.edu.co/index.php/usalud/article/view/2400

Jacob Paredes, D., Buenaño Allauca, M. P., & Mancera Rodríguez, N. J. (2015). Usos de plantas medicinales en la comunidad San Jacinto del Cantón Ventanas, Los Ríos–Ecuador. https://revistas.udca.edu.co/index.php/ruadc/article/view/452

Ji, H., Kim, H., Beuchat, L. R., & Ryu, J. H. (2019). Synergistic antimicrobial activities of essential oil vapours against Penicillium corylophilum on a laboratory medium and beef jerky. International journal of food microbiology, 291, 104-110. https://doi.org/10.1016/j.ijfoodmicro.2018.11.023

Khosravi, A. R., Sharifzadeh, A., Nikaein, D., Almaie, Z., & Nasrabadi, H. G. (2018). Chemical composition, antioxidant activity and antifungal effects of five Iranian essential oils against Candida strains isolated from urine samples. Journal de mycologie medicale, 28(2), 355-360. https://doi.org/10.1016/j.mycmed.2018.01.005

Kim, Y. W., You, H. J., Lee, S., Kim, B., Kim, D. K., Choi, J. B., & Lee, S. J. (2017). Inactivation of norovirus by lemongrass essential oil using a norovirus surrogate system. Journal of food protection, 80(8), 1293-1302. https://doi.org/10.4315/0362-028X.JFP-16-162

Kpodar, M. S., Karou, S. D., Katawa, G., Anani, K., Gbekley, H. E., Adjrah, Y., & Simpore, J. (2016). An ethnobotanical study of plants used to treat liver diseases in the Maritime region of Togo. Journal of ethnopharmacology, 181, 263-273. https://doi.org/10.1016/j.jep.2015.12.051

Leite, C. J. B., de SOUSA, J. P., da Costa Medeiros, J. A., da CONCEIÇÃO, M. L., dos Santos Falcão-Silva, V., & de SOUZA, E. L. (2016). Inactivation of Escherichia coli, Listeria monocytogenes, and Salmonella Enteritidis by Cymbopogon citratus DC Stapf. essential oil in pineapple juice. Journal of food protection, 79(2), 213-219. https://doi.org/10.4315/0362-028X.JFP-15-245

Liakos, I. L., Abdellatif, M. H., Innocenti, C., Scarpellini, A., Carzino, R., Brunetti, V., & Pompa, P. P. (2016). Antimicrobial lemongrass essential oil—copper ferrite cellulose acetate nanocapsules. Molecules, 21(4), 520. https://doi.org/10.3390/molecules21040520

Limoncu, M. E., Balcıoğlu, C., Oyur, T., Zeybek, G., & Zeybek, U. (2017). In vitro Investigation of the Pediculicidal Activities of the Volatile Oil Components of Some Medical Plants Raised in Turkey. Turkiye parazitolojii dergisi, 41(4), 208-213. https://doi.org/10.5152/tpd.2017.5201

Liu, B. T., Li, X., Zhang, Q., Shan, H., Zou, M., & Song, F. J. (2019). Colistin-resistant mcr-positive Enterobacteriaceae in fresh vegetables, an increasing infectious threat in China. International journal of antimicrobial agents, 54(1), 89-94. https://doi.org/10.1016/j.ijantimicag.2019.04.013

LORENZI, H., & MATOS, F. J. A. (2008) Plantas medicinais no Brasil: Nativas e exóticas. (2th ed.) São Paulo: Instituto Plantarum de Estudos da Flora LTDA.

Luís, Â., Duarte, A. P., Pereira, L., & Domingues, F. (2017). Chemical profiling and evaluation of antioxidant and anti-microbial properties of selected commercial essential oils: A comparative study. Medicines, 4(2), 36. https://doi.org/10.3390/medicines4020036

Macedo, I. T. F., Oliveira, L. M. B. D., Ribeiro, W. L. C., Santos, J. M. L. D., Silva, K. D. C., Araújo Filho, J. V. D., & Bevilaqua, C. M. L. (2015). Anthelmintic activity of Cymbopogon citratus against Haemonchus contortus. Revista Brasileira de Parasitologia Veterinária, 24(3), 268-275. https://doi.org/10.1590/S1984-29612015059

Macedo, I. T. F., Oliveira, L. M. B. D., André, W. P. P., Araújo Filho, J. V. D., Santos, J. M. L. D., Rondon, F. C. M., & Bevilaqua, C. M. L. (2019). Anthelmintic effect of Cymbopogon citratus essential oil and its nanoemulsion on sheep gastrointestinal nematodes. Revista Brasileira de Parasitologia Veterinária, 28(3), 522-527. http://dx.doi.org/10.1590/s1984-29612019065

Marconi, M. A.; Lakatos, E. M. (2017). Fundamentos de metodologia científica. São Paulo: Atlas.

Méabed, E. M., Abou-Sreea, A. I., & Roby, M. H. (2018). Chemical analysis and giardicidal effectiveness of the aqueous extract of Cymbopogon citratus Stapf. Parasitology research, 117(6), 1745-1755. https://doi.org/10.1007/s00436-018-5855-1

Miguéis, G. D. S., da Silva, R. H., Damasceno Júnior, G. A., & Guarim-Neto, G. (2019). Plants used by the rural community of Bananal, Mato Grosso, Brazil: Aspects of popular knowledge. PloS one, 14(1), e0210488. https://doi.org/10.1371/journal.pone.0210488

Mota, C. M., Rodrigues-Santos, C., Carolino, R. O., Anselmo-Franci, J. A., & Branco, L. G. (2020). Citral-induced analgesia is associated with increased spinal serotonin, reduced spinal nociceptive signaling, and reduced systemic oxidative stress in arthritis. Journal of ethnopharmacology, 250, 112486. https://doi.org/10.1016/j.jep.2019.112486

Nguta, J. M., Appiah-Opong, R., Nyarko, A. K., Yeboah-Manu, D., & Addo, P. G. (2015). Medicinal plants used to treat TB in Ghana. International Journal of Mycobacteriology, 4(2), 116-123. https://doi.org/10.1016/j.ijmyco.2015.02.003

Nguyen, T. V. L., Nguyen, M. D., Nguyen, D. C., Bach, L. G., & Lam, T. D. (2019). Model for thin layer drying of lemongrass (Cymbopogon citratus) by hot air. Processes, 7(1), 21. https://doi.org/10.3390/pr7010021

Odoh, U. E., Uzor, P. F., Eze, C. L., Akunne, T. C., Onyegbulam, C. M., & Osadebe, P. O. (2018). Medicinal plants used by the people of Nsukka Local Government Area, south-eastern Nigeria for the treatment of malaria: An ethnobotanical survey. Journal of ethnopharmacology, 218, 1-15. https://doi.org/10.1016/j.jep.2018.02.034

Oliveira, J. B., Teixeira, M. A., Paiva, L. F. D., Oliveira, R. F. D., Mendonça, A. R. D. A., & Brito, M. J. A. D. (2019). In vitro and in vivo antimicrobial activity of Cymbopogon citratus (DC.) Stapf. against Staphylococcus spp. isolated from newborn babies in an intensive care unit. Microbial Drug Resistance, 25(10), 1490-1496. https://doi.org/10.1089/mdr.2018.0047

Pardo, R., Sati, H., & Galas, M. (2018). " One health" approach in the actions to address antimicrobial resistance from a latin american standpoint. Revista peruana de medicina experimental y salud publica, 35(1), 103-109. https://doi.org/10.17843/rpmesp.2018.351.3605

Pontes, E. K. U., Melo, H. M., Nogueira, J. W. A., Firmino, N. C. S., de Carvalho, M. G., Júnior, F. E. A. C., & Cavalcante, T. T. A. (2019). Antibiofilm activity of the essential oil of citronella (Cymbopogon nardus) and its major component, geraniol, on the bacterial biofilms of Staphylococcus aureus. Food science and biotechnology, 28(3), 633-639. https://doi.org/10.1007/s10068-018-0502-2

Rodrigues, K. A., Oliveira, L. S., Neto, F. R., de Araújo, M. P., & Gomes, D. C. V. (2017). O uso de plantas medicinais pela comunidade da zona norte de Teresina–Pi e seus fins terapêuticos. Revista Interdisciplinar, 10(4), 77-81. https://revistainterdisciplinar.uninovafapi.edu.br/index.php/revinter/article/view/1228

Rosmalena, R., Elya, B., Dewi, B. E., Fithriyah, F., Desti, H., Angelina, M., & Seto, D. (2019). The antiviral effect of indonesian medicinal plant extracts against dengue virus in vitro and in silico. Pathogens, 8(2), 85. https://doi.org/10.3390/pathogens8020085

Rossi, G. G., Guterres, K. B., Bonez, P. C., da Silva Gundel, S., Aggertt, V. A., Siqueira, F. S., & de Campos, M. M. A. (2017). Antibiofilm activity of nanoemulsions of Cymbopogon flexuosus against rapidly growing mycobacteria. Microbial pathogenesis, 113, 335-341. https://doi.org/10.1016/j.micpath.2017.11.002

Sahal, G., Woerdenbag, H. J., Hinrichs, W. L., Visser, A., Tepper, P. G., Quax, W. J., ... & Bilkay, I. S. (2020). Antifungal and biofilm inhibitory effect of Cymbopogon citratus (lemongrass) essential oil on biofilm forming by Candida tropicalis isolates; an in vitro study. Journal of ethnopharmacology, 246, 112188. https://doi.org/10.1016/j.jep.2019.112188

Santos, J. A. D., Silveira, A. P., & Gomes, V. D. S. (2019). Knowledge and Use of the Flora in a Quilombola Community of Northeastern Brazil. Floresta e Ambiente, 26(3). https://doi.org/10.1590/2179-8087.093217

Santos, P. L., Matos, J. P. S., Picot, L., Almeida, J. R., Quintans, J. S., & Quintans-Júnior, L. J. (2019). Citronellol, a monoterpene alcohol with promising pharmacological activities-A systematic review. Food and Chemical Toxicology, 123, 459-469. https://doi.org/10.1016/j.fct.2018.11.030

Scazzocchio, F., Garzoli, S., Conti, C., Leone, C., Renaioli, C., Pepi, F., & Angiolella, L. (2016). Properties and limits of some essential oils: chemical characterisation, antimicrobial activity, interaction with antibiotics and cytotoxicity. Natural product research, 30(17), 1909-1918. https://doi.org/10.1080/14786419.2015.1086346

Seibert, J. B., Viegas, J. S., Almeida, T. C., Amparo, T. R., Rodrigues, I. V., Lanza, J. S., & Dos Santos, O. D. (2019). Nanostructured systems improve the antimicrobial potential of the essential oil from Cymbopogon densiflorus leaves. Journal of natural products, 82(12), 3208-3220. https://doi.org/10.1021/acs.jnatprod.8b00870

Silva, N. B. D., Rangel, M. D. L., Castro, R. D. D., Lima, J. M. D., Castellano, L. R. C., Valença, A. M. G., & Cavalcanti, A. L. (2019). Anti-Biofilm and Hemolytic Effects of Cymbopogon citratus (Dc) Stapf Essential Oil. Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 19. http://dx.doi.org/10.4034/pboci.2019.191.103

Singh, S., Fatima, Z., & Hameed, S. (2016). Citronellal-induced disruption of membrane homeostasis in Candida albicans and attenuation of its virulence attributes. Revista da Sociedade Brasileira de Medicina Tropical, 49(4), 465-472. http://dx.doi.org/10.1590/0037-8682-0190-2016

Souza, A. A., Dias, N. A. A., Piccoli, R. H., & Bertolucci, S. K. V. (2016). Composição química e concentração mínima bactericida de dezesseis óleos essenciais sobre Escherichia coli enterotoxigênica. Revista Brasileira de Plantas Medicinais, 18(1), 105-112. https://doi.org/10.1590/1983-084X/15_050

Suroowan, S., & Mahomoodally, M. F. (2016). A comparative ethnopharmacological analysis of traditional medicine used against respiratory tract diseases in Mauritius. Journal of ethnopharmacology, 177, 61-80. https://doi.org/10.1016/j.jep.2015.11.029

Trindade, L. A., de Araújo Oliveira, J., de Castro, R. D., & de Oliveira Lima, E. (2015). Inhibition of adherence of C. albicans to dental implants and cover screws by Cymbopogon nardus essential oil and citronellal. Clinical oral investigations, 19(9), 2223-2231. https://doi.org/10.1007/s00784-015-1450-3

WORLD HEALTH ORGANIZATION (2019) Ten threats to global health in 2019. Disponível em: https://www.who.int/emergencies/ten-threats-to-global-health-in-2019. Acesso em: 30 de julho de 2020.

Wu, H., Li, J., Jia, Y., Xiao, Z., Li, P., Xie, Y., & Li, C. (2019). Essential oil extracted from Cymbopogon citronella leaves by supercritical carbon dioxide: antioxidant and antimicrobial activities. Journal of analytical methods in chemistry, 2019. https://doi.org/10.1155/2019/8192439

Downloads

Published

06/07/2022

How to Cite

PRADO, G. M.; PRADO, J. C. S. .; PINHEIRO, C. V. F. .; DAZA-CARDONA, E. A.; BARBOSA, F. C. B. .; SOUZA, E. B. de .; FONTENELLE, R. O. dos S. . Cymbopogon sp. from ethnobotany to antimicrobial: an integrative review. Research, Society and Development, [S. l.], v. 11, n. 9, p. e19211931587, 2022. DOI: 10.33448/rsd-v11i9.31587. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/31587. Acesso em: 27 apr. 2024.

Issue

Section

Review Article