PÓS-COVID-19: Sintomas persistentes e sua relação com o nível de fadiga

Autores

DOI:

https://doi.org/10.33448/rsd-v12i2.40235

Palavras-chave:

COVID-19; Sinais e sintomas; Fadiga.

Resumo

Os sintomas persistentes pós-COVID-19 parecem semelhantes à de outras síndromes de fadiga pós-infecciosa, principalmente quando persistente além de seis meses. Sendo assim, o objetivo do estudo foi avaliar os sintomas persistentes e sua relação com o nível de fadiga, especialmente acima de seis meses pós-COVID-19. Os indivíduos foram convidados por redes sociais e o questionário foi disponibilizado por meio de um link online utilizando a plataforma Google Forms. O termo de consentimento livre e esclarecido foi disponibilizado na primeira página do formulário e em seguida os indivíduos responderam ao questionário sobre sintomas persistentes e nível de fadiga pela escala FACIT-F. O teste de Mann Whitney foi utilizado para comparar a pontuação do FACIT-F entre os indivíduos com e sem sintomas pós-COVID-19 tanto para o grupo total, quanto para aqueles que continuaram com sintomas após 6 meses da COVID-19. Após a coleta de dados observou-se que os sintomas mais relatados foram: queda de cabelo (43%), esquecimento/perda de memória (30,6%), sudorese (23,8%), fraqueza muscular (21,2%), dispneia (20,2%), dor de cabeça (16,6%), problemas para dormir (15%), confusão ou falta de concentração (14%), tosse seca (12,4%), quadro álgico ou edema nas articulações (11,9%), alteração de olfato e paladar (11,9%), dor muscular persistente e palpitações (11,4%). O nível de fadiga foi maior para aqueles com presença de sintomas. Deste modo, conclui-se que houve uma heterogeneidade na prevalência dos sintomas, porém aqueles com sintomas apresentaram um nível de fadiga maior, especialmente após seis meses pós-COVID-19.

Referências

Ahmed, H., Patel, K., Greenwood, D. C., et al. (2020). Long term clinical outcomes in survivors of severe acute respiratory syndrome (SARS) and middle east respiratory syndrome (MERS) coronavirus out breaks alter hospitalization or ICU admission: A systematic review and meta-analysis. Journal of Rehabilitation Medicine, May 31;52(5):jrm00063. 10.2340/16501977-2694.

Alkodaymi, M. S., Omrani, O. A., Fawzy, N. A., et al. (2022). Prevalence of post-acute COVID-19 syndrome symptoms at different follow-up periods: a systematic review and meta-analysis. Clinical Microbiology and Infection, May;28(5):657-666. 10.1016/j.cmi.2022.01.014.

Alzueta, E., Perrin, P.B., Yuksel, D., et al. (2022). An international study of post-COVID sleep health. Sleep Health, 8(6):684-690. 10.1016/j.sleh.2022.06.011.

Baig, A. M. (2020). Neurological manifestations in COVID-19 caused by SARS-CoV-2. CNS Neuroscience & Therapeutics, May;26(5):499-501. 10.1111/cns.13372.

Carfì, A., et al. (2020). Persistent Symptoms in Patients After Acute COVID-19. Journal of the American Medical Association, 324(6):603-605.10.1001/jama.2020.12603.

Cella, D., Yount, S., Sorensen, M., Chartash, E., Sengupta, N., & Grober, J. (2005). Validation of the functional assessment of chronic illness therapy fatigue scale relative to other instrumentation in patients with rheumatoid arthritis. Journal of Rheumatology, May;32(5):811-9. PMID: 15868614.

Chen, N., Zhou, M., Dong, X., et al. (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. Feb 15;395(10223):507-513. 10.1016/S0140-6736(20)30211-7.

Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; Board on the Health of Select Populations; Institute of Medicine. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness. Washington (DC): National Academies Press (US); 2015 Feb 10.

Disser, N. P., De Micheli, A. J., Schonk, M. M., et al. (2020). Musculoskeletal Consequences of COVID-19. Journal of bone and joint surgery. American volume, Jul 15;102(14):1197-1204. 10.2106/JBJS.20.00847.

Fernández-de-Las-Peñas, C., Palacios-Ceña, D., Gómez-Mayordomo, V., et al. (2021). Prevalence of post-COVID-19 symptoms in hospitalized and non-hospitalized COVID-19 survivors: A systematic review and meta-analysis. European Journal of Internal Medicine, Oct;92:55-70. 10.1016/j.ejim.2021.06.009.

Garrigues, E., Janvier, P., Kherabi, Y., et al. (2020). Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19. Journal of Infection, Dec;81(6):e4-e6. 10.1016/j.jinf.2020.08.029.

González-Hermosillo, J. A., Martínez-López, J. P., Carrillo-Lampón, S. A., et al. (2021). Post-Acute COVID-19 Symptoms, a Potential Link with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A 6-Month Survey in a Mexican Cohort. Brain Sciences, Jun 8;11(6):760. 10.3390/brainsci11060760.

Greenhalgh, T., et al. (2020). Management of post-acute covid-19 in primary care. British Medical Journal, 370:m3026. 10.1136/bmj.m3026.

Hayes. L. D., Ingram, J., & Sculthorpe, N. F. (2021). More Than 100 Persistent Symptoms of SARS-CoV-2 (Long COVID): A Scoping Review. Frontiers in Medicine (Lausanne), Nov 1;8:750378. 10.3389/fmed.2021.750378

Hickie, I., Davenport, T., Wakefield, D., et al. (2006). Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: Prospective cohort study. British Medical Journal, 16;333(7568):575. 10.1136/bmj.38933.585764.AE.

Huang, C., et al. (2021). 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet, 397: 220–32.10.1016/ S0140-6736(20)32656-8.

Huang, C., Wang, Y., Li, X., et al. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, Feb 15;395(10223):497-506.10.1016/S0140-6736(20)30183-5.

Joli, J., Buck, P., Zipfel, S., & Stengel, A. (2022). Post-COVID-19 fatigue: A systematic review. Frontiers in Psychiatry, Aug 11;13:947973. 10.3389/fpsyt.2022.947973.

Komaroff, A. L., & Bateman, L. (2021). Will COVID-19 Lead to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome? Frontiers in Medicine, Jan 18;7:606824. 10.3389/fmed.2020.606824.

Komaroff, A. L., & Lipkin, W. I. (2021). Insights from myalgic encephalomyelitis/chronic fatigue syndrome may help unravel the pathogenesis of postacute COVID-19 syndrome. Trends in Molecular Medicine, 27(9): 895-906.10.1016/j.molmed.2021.06.002.

Lopez-Leon, S., Wegman-Ostrosky, T., Perelman, C., et al. (2021). More than 50 Long-term effects of COVID-19: a systematic review and meta-analysis. Scientific Reports, 11, 16144. https://doi.org/10.1038/s41598-021-95565-8

Lu, R., Zhao, X., Li, J., et al. (2020). Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet, Feb 22;395(10224):565-74. doi.org/10.1016/S0140-6736(20)30251-8.

Mandal, S., Barnett, J., Brill, S. E., et al. (2021). 'Long-COVID': a cross-sectional study of persisting symptoms, biomarker and imaging abnormalities following hospitalisation for COVID-19. Thorax, Apr;76(4):396-398. 10.1136/thoraxjnl-2020-215818.

Mao, L., Jin, H., Wang, M., et al. (2020). Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurology, 77(6):683-690.10.1001/jamaneurol.2020.1127

Moreno-Pérez, O., Merino, E., Leon-Ramirez, J. M., et al. (2021). Post-acute COVID-19 syndrome. Incidence and risk factors: A Mediterranean cohort study. Journal of Infection, Mar;82(3):378-383. 10.1016/j.jinf.2021.01.004.

Nalbandian, A., Sehgal, K., Gupta, A., et al. (2021). Post-acute COVID-19 syndrome. Nature Medicine, Apr;27(4):601-615. doi.org/10.1038/s41591-021-01283-z.

Nehme, M., Braillard, O., Chappuis, F., Courvoisier, D. S., & Guessous, I. T. (2021). Prevalence of symptoms more than seven months after diagnosis of symptomatic COVID-19 in an outpatient setting. Annals of Internal Medicine, Sep;174(9):1252-1260. 10.7326/M21-0878.

Nieman, D. C. (2021). Exercise Is Medicine for Immune Function: Implication for COVID-19. Current Sports Medicine Reports, Aug 1;20(8):395-401. 10.1249/JSR.0000000000000867.

Niklassen, A. S., Draf, J., Huart, C., et al. (2021). COVID-19: Recovery from Chemosensory Dysfunction. A Multicentre study on Smell and Taste. Laryngoscope, May;131(5):1095-1100. 10.1002/lary.29383.

Poenaru, S., Abdallah, S.J., Corrales-Medina, V., & Cowan, J. (2021). COVID-19 and post-infectious myalgic encephalomyelitis/chronic fatigue syndrome: a narrative review. Therapeutic Advances in Infectious Disease, Apr 20;8:20499361211009385. 10.1177/20499361211009385.

Ren, L. L., Wang, Y. M., Wu, Z. Q., et al. (2020). Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study. Chinese Medical Journal, May 5;133(9):1015-24. 10.1097/CM9.0000000000000722.

Rudroff, T., Fietsam, A. C., Deters, J. R., Bryant, A. D., & Kamholz, J. (2020). Post-COVID-19 Fatigue: Potential Contributing Factors. Brain Sciences, Dec 19;10(12):1012. 10.3390/brainsci10121012.

Silva, R. N., Goulart, C. D. L., Oliveira, M. R., et al. (2021). Cardiorespiratory and skeletal muscle damage due to COVID-19: making the urgent case for rehabilitation. Expert Review of Respiratory Medicine, Sep;15(9):1107-1120. 10.1080/17476348.2021.1893169.

Spruit, M. A., et al. (2020). COVID-19: interim guidance on rehabilitation in the hospital and post-hospital phase from a European Respiratory Society- and American Thoracic Society-coordinated international task force. European Respiratory Journal, Dec; 56(6): 2002197. 10.1183/13993003.02197-2020.

Taboada, M., Moreno, E., Cariñena, A., et al. (2021). Quality of life, functional status, and persistent symptoms after intensive care of COVID-19 patients. British Journal of Anaesthesia, Mar;126(3):e110-e113. 10.1016/j.bja.2020.12.002.

Townsend, L., Dyer, A. H., Jones, K., et al. (2020). Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection. PLOS ONE, Nov 9;15(11):e0240784. 10.1371/journal.pone.0240784.

Wiersinga, W. J., Rhodes, A., Cheng, A. C., Peacock, S. J., & Prescott, H. C. (2020). Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19). Journal of the American Medical Association, Aug 25;324(8):782-793. 10.1001/jama.2020.12839.

Wong, T. L., & Weitzer, D. J. (2021). Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systemic Review and Comparison of Clinical Presentation and Symptomatology. Medicine (Kaunas), Apr 26;57(5):418. 10.3390/medicina57050418.

Woo, M. S., Malsy, J., Pöttgen, J., et al. (2020). Frequent neurocognitive deficits after recovery from mild COVID-19. Brain Communications, Nov 23;2(2):fcaa205. 10.1093/braincomms/fcaa205.

Wu, F., Zhao, S., Yu, B., et al. (2020). A new coronavirus associated with human respiratory disease in China. Nature, 579, 265–269. 10.1038/s41586-020-2008-3.

Xiong, Q., Xu, M., Li, J., et al. (2021). Clinical sequelae of COVID-19 survivors in Wuhan, China: a single-centre longitudinal study. Clinical Microbiology and Infection, Jan;27(1):89-95. 10.1016/j.cmi.2020.09.023.

Yiying Huang, Y., Cuiyan Tan, C., Jian Wu, J., et al. (2020). Impact of coronavirus disease 2019 on pulmonary function in early convalescence phase. Respiratory Research, Jun 29;21(1):163. 10.1186/s12931-020-01429-6.

Zhu, N., Zhang, D., Wang, W., et al. (2020). A novel coronavirus from patients with pneumonia in China, 2019. New England Journal of Medicine, Feb 20;382(8):727-33. 10.1056/NEJMoa2001017.

Downloads

Publicado

12/02/2023

Como Citar

OTA, L. S.; NAKAMATSU, A. P. .; ALVES, Érica O. .; FRÉ, G. G. P. .; TREVISAN, I. B. PÓS-COVID-19: Sintomas persistentes e sua relação com o nível de fadiga . Research, Society and Development, [S. l.], v. 12, n. 2, p. e27312240235, 2023. DOI: 10.33448/rsd-v12i2.40235. Disponível em: https://www.rsdjournal.org/index.php/rsd/article/view/40235. Acesso em: 14 maio. 2024.

Edição

Seção

Ciências da Saúde