Hormonal differences between men and women and their impact on physical exercise practice: A narrative literature review
DOI:
https://doi.org/10.33448/rsd-v15i4.50924Keywords:
Sex Hormones, Athletic Performance, Gender, Physical Exercise.Abstract
This study aims to analyze hormonal differences between men and women and understand how these variations influence the practice of physical exercise, highlighting the importance of personalizing training programs according to hormonal profiles, especially considering the female menstrual cycle. This is a narrative literature review conducted using scientific articles indexed in relevant databases. The analyzed topics included hormonal physiology; the effects of testosterone on muscle strength and hypertrophy; the influence of estrogen on recovery and aerobic endurance; the role of progesterone in thermoregulation and fluid retention; and performance variations related to menstrual cycle phases and hormonal contraceptive use. The findings showed that hormonal differences significantly influence physical performance. Testosterone was associated with greater muscle strength, hypertrophy, and oxygen transport capacity in men. Estrogen contributed to improved muscle recovery, lipid metabolism, and anti-inflammatory responses in women. Progesterone was related to increased fatigue and thermoregulation changes. Performance variations were also observed according to menstrual cycle phases and hormonal contraceptive use. Hormonal differences between men and women directly affect responses to physical exercise, reinforcing the need for individualized training strategies. Considering hormonal profiles—especially menstrual cycle variations—is essential to optimize performance, prevent injuries, and promote safer and more inclusive exercise practices.
References
Associação Brasileira para o Estudo da Obesidade e Síndrome Metabólica. (2025). Comparação de desempenho físico entre homens e mulheres. https://abeso.org.br/comparacao-de-desempenho-fisico-entre-homens-e-mulheres
Bachman, E., Travison, T. G., Basaria, S., Davda, M. N., Guo, W., Li, M., & Bhasin, S. (2010). Testosterone suppresses hepcidin in men: A potential mechanism for testosterone-induced erythrocytosis. The Journal of Clinical Endocrinology & Metabolism, 95(7), 3335–3345. https://doi.org/10.1210/jc.2010-0425
Bear, M. F., Connors, B. W., & Paradiso, M. A. (2020). Neurociências: Desvendando o sistema nervoso (4ª ed.). Artmed.
Beery, A. K. (2015). Antisocial oxytocin: Complex effects on social behavior. Current Opinion in Behavioral Sciences, 6, 174–182. https://doi.org/10.1016/j.cobeha.2015.11.006
Brown, L. E., & Miller, J. (2005). NSCA’s essentials of strength training and conditioning. National Strength and Conditioning Association.
Campbell, S. E., Angus, D. J., & Febbraio, M. A. (2001). Glucose kinetics and exercise performance during phases of the menstrual cycle. Journal of Applied Physiology, 91(2), 474–481.
Cohen, M. (2024, October 21). Tríade da mulher atleta: O que é e como prevenir a síndrome. Boa Forma. https://boaforma.abril.com.br/coluna/boa-forma-responde/triade-da-mulher-atleta/
Constantini, N. W., Dubnov, G., & Lebrun, C. M. (2005). The menstrual cycle and sport performance. Clinics in Sports Medicine, 24(2), e51–e82. https://doi.org/10.1016/j.csm.2005.01.003
Dishman, R. K., & O’Connor, P. J. (2009). Lessons in exercise neurobiology: The case of endorphins. Mental Health and Physical Activity, 2(1), 4–9. https://doi.org/10.1016/j.mhpa.2008.12.002
Elliott-Sale, K. J., McNulty, K. L., Ansdell, P., et al. (2021). The effects of menstrual cycle phase on exercise performance in eumenorrheic women: A systematic review and meta-analysis. Sports Medicine, 51(2), 287–302.
Enns, D. L., & Tiidus, P. M. (2010). Estrogen influences on skeletal muscle: Mechanistic and clinical perspectives. Sports Medicine, 40(1), 41–58.
Fernandes, J. M. B., Vieira, L. T. & Castelhano, M. V. C. (2023). Revisão narrativa enquanto metodologia científica significativa: reflexões técnico-formativas. REDES – Revista Educacional da Sucesso. 3(1), 1-7. ISSN: 2763-6704.
Frystyk, J. (2009). The growth hormone/insulin-like growth factor-I axis in exercise and sport. Growth Hormone & IGF Research, 19(4), 308–319.
Guyton, A. C., & Hall, J. E. (2017). Tratado de fisiologia médica (13ª ed.). Elsevier.
Guyton, A. C., & Hall, J. E. (2021). Tratado de fisiologia médica (14ª ed.). Guanabara Koogan.
Hackney, A. C. (2020). Hypogonadism in exercising males: Dysfunction or adaptive-regulatory adjustment? Frontiers in Endocrinology, 11, 11. https://doi.org/10.3389/fendo.2020.00011
Hansen, L., Bangsbo, J., Twik, J., & Klausen, K. (1999). Development of muscle strength in relation to training level and testosterone in young male soccer players. Journal of Applied Physiology, 1141–1147.
Heinrichs, M., von Dawans, B., & Domes, G. (2009). Oxytocin, vasopressin, and human social behavior. Frontiers in Neuroendocrinology, 30(4), 548–557.
Herzberg, S. D., Motu’apuaka, M. L., Lambert, W., Fu, R., Brady, J., Guise, J. M., & Korthuis, P. T. (2017). The effect of menstrual cycle and contraceptives on ACL injuries and laxity: A systematic review and meta-analysis. Orthopaedic Journal of Sports Medicine, 5(7).
Hicks, K. M., Onambélé, G. L., Winwood, K., & Morse, C. I. (2017). Muscle damage following exercise in women: A review of hormonal influences across the menstrual cycle. European Journal of Applied Physiology, 117(4), 613–632.
Hunter, G. R., Demment, R., & Miller, D. (2004). Gender differences in strength and power. Journal of Strength and Conditioning Research, 18(1), 242–246.
Janse de Jonge, X. A. K. (2003). Effects of the menstrual cycle on exercise performance. Sports Medicine, 33(11), 833–851.
Jenkins, P. J. (2001). Growth hormone and exercise: Physiology, use and abuse. Growth Hormone & IGF Research, 11(Suppl A), S71–S77.
Joyner, M. J. (2017). Physiological limits to endurance exercise performance: Influence of sex. Journal of Physiology, 595(9), 2949–2950.
Kanayama, G., Hudson, J. I., & Pope, H. G. (2008). Long-term psychiatric and medical consequences of anabolic–androgenic steroid abuse: A looming public health concern. Drug and Alcohol Dependence, 98(1–2), 1–12.
Kandel, E. R., Koester, J. D., Mack, S. H., & Siegelbaum, S. A. (2021). Principles of neural science (6th ed.). McGraw-Hill.
Kraemer, W. J., & Ratamess, N. A. (2005). Hormonal responses and adaptations to resistance exercise and training. Sports Medicine, 35(4), 339–361.
Loucks, A. B., & Thuma, J. R. (2003). Luteinizing hormone pulsatility is disrupted at a threshold of energy availability in regularly menstruating women. The Journal of Clinical Endocrinology & Metabolism, 88(1), 297–311.
Markovic, G., Jukic, I., Milanovic, D., & Metikos, D. (2007). Effects of sprint and plyometric training on muscle function and athletic performance. Journal of Strength & Conditioning Research, 21(2), 543–549.
Melmed, S., Polonsky, K. S., Larsen, P. R., & Kronenberg, H. M. (2016). Williams textbook of endocrinology (13th ed.). Elsevier.
Mendes, K. D. S., Silveira, R. C. C. P., & Galvão, C. M. (2008). Revisão integrativa: Método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & Contexto – Enfermagem, 17(4), 758–764.
Pareja-Blanco, F., Rodríguez-Rosell, D., Sánchez-Medina, L., Gorostiaga, E. M., & González-Badillo, J. J. (2014). Effect of movement velocity during resistance training on neuromuscular performance. International Journal of Sports Medicine, 35(11), 916–924.
Powers, S. K., & Howley, E. T. (2017). Fisiologia do exercício: Teoria e aplicação ao condicionamento e ao desempenho (9ª ed.). AMGH.
Reiter, R. J., Tan, D. X., Manchester, L. C., & Tamura, H. (2009). Melatonin and reproduction revisited. Biology of Reproduction, 81(3), 445–456.
Sá, A. C. M. G. N., et al. (2023). Blood count reference intervals for the Brazilian adult population: National Health Survey. Revista Brasileira de Epidemiologia, 26, e230004.
Schaumberg, M. A., Jenkins, D. G., Janse de Jonge, X. A., Emmerton, L. M., & Skinner, T. L. (2017). Three-step method for menstrual and oral contraceptive cycle verification. Journal of Science and Medicine in Sport, 20(10), 965–969.
Schiebinger, L. (2016). Gendered innovations in science, health & medicine, engineering, and environment. Stanford University Press.
Schumacher, M., Guennoun, R., Stein, D. G., De Nicola, A. F., & Akwa, Y. (2007). Progesterone: Therapeutic opportunities for neuroprotection and myelin repair. Pharmacology & Therapeutics, 116(1), 77–106.
Senefeld, J., Hunter, S. K., & Enoka, R. (2021). Sex differences in fatigability of dynamic muscle actions: A systematic review. Medicine & Science in Sports & Exercise, 53(4), 785–796.
Snyder, H. (2019). Literature review as a research methodology: An overview and guidelines. Journal of Business Research. 104, 333-9. https://doi.org/10.1016/j.jbusres.2019.07.039.
Storer, T. W., Woodhouse, L., Magliano, L., Singh, A. B., Dzekov, J., Dzekov, C., & Bhasin, S. (2003). Testosterone dose–response relationships in healthy young men. American Journal of Physiology-Endocrinology and Metabolism, 284(4), E716–E725.
Straub, R. H. (2007). The complex role of estrogens and progesterone in inflammation. Endocrine Reviews, 28(5), 521–574.
Toffoletto, S., Lanzenberger, R., Gingnell, M., Sundström-Poromaa, I., & Comasco, E. (2014). Emotional and cognitive changes across the menstrual cycle: A neurobiological perspective. Frontiers in Neuroscience, 8, 380.
United Nations. (1979). Convention on the elimination of all forms of discrimination against women. https://www.ohchr.org/sites/default/files/Documents/ProfessionalInterest/cedaw.pdf
Uvnas-Moberg, K., Handlin, L., & Petersson, M. (2015). Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation. Frontiers in Psychology, 5, 1529.
Wang, D. (2023). The differences between modern modes of biathlon training at the Olympic Winter Games. Revista Brasileira de Medicina do Esporte, 29, e2022_0300.
Zisapel, N. (2018). New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. British Journal of Pharmacology, 175(16), 3190–3199.
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